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Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy: a prospective, randomized study with a follow-up to the age of 2 years.
J Pediatr. 2002 Feb; 140(2):219-24.JPed

Abstract

OBJECTIVES

We conducted a prospective, randomized study to evaluate the cumulative incidence of allergy or other adverse reactions to soy formula and to extensively hydrolyzed formula up to the age of 2 years in infants with confirmed cow's milk allergy.

STUDY DESIGN

Infants (n = 170) with documented cow's milk allergy were randomly assigned to receive either a soy formula or an extensively hydrolyzed formula. If it was suspected that the formula caused symptoms, a double-blind, placebo-controlled challenge (DBPCFC) with the formula was performed. The children were followed to the age of 2 years, and soy-specific immunoglobulin E antibodies were measured at the time of diagnosis and at the ages of 1 and 2 years.

RESULTS

An adverse reaction to the formula was confirmed by challenge in 8 patients (10%; 95% confidence interval, 4.4%-18.8%) randomly assigned to soy formula and in 2 patients (2.2%; 95% confidence interval, 0.3% to 7.8%) randomly assigned to extensively hydrolyzed formula. Adverse reactions to soy were similar in IgE-associated and non-IgE-associated cow's milk allergy (11% and 9%, respectively). IgE to soy was detected in only 2 infants with an adverse reaction to soy. Adverse reactions to soy formula were more common in younger (<6 months) than in older (6 to 12 months) infants (5 of 20 vs 3 of 60, respectively, P =.01).

CONCLUSIONS

Soy formula was well tolerated by most infants with IgE-associated and non-IgE-associated cow's milk allergy. Development of IgE-associated allergy to soy was rare. Soy formula can be recommended as a first-choice alternative for infants >or=6 months of age with cow's milk allergy.

Authors+Show Affiliations

Department of Pediatrics, Jorvi Hospital, Espoo, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11865274

Citation

Klemola, Timo, et al. "Allergy to Soy Formula and to Extensively Hydrolyzed Whey Formula in Infants With Cow's Milk Allergy: a Prospective, Randomized Study With a Follow-up to the Age of 2 Years." The Journal of Pediatrics, vol. 140, no. 2, 2002, pp. 219-24.
Klemola T, Vanto T, Juntunen-Backman K, et al. Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy: a prospective, randomized study with a follow-up to the age of 2 years. J Pediatr. 2002;140(2):219-24.
Klemola, T., Vanto, T., Juntunen-Backman, K., Kalimo, K., Korpela, R., & Varjonen, E. (2002). Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy: a prospective, randomized study with a follow-up to the age of 2 years. The Journal of Pediatrics, 140(2), 219-24.
Klemola T, et al. Allergy to Soy Formula and to Extensively Hydrolyzed Whey Formula in Infants With Cow's Milk Allergy: a Prospective, Randomized Study With a Follow-up to the Age of 2 Years. J Pediatr. 2002;140(2):219-24. PubMed PMID: 11865274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy: a prospective, randomized study with a follow-up to the age of 2 years. AU - Klemola,Timo, AU - Vanto,Timo, AU - Juntunen-Backman,Kaisu, AU - Kalimo,Kirsti, AU - Korpela,Riitta, AU - Varjonen,Elina, PY - 2002/2/28/pubmed PY - 2002/3/22/medline PY - 2002/2/28/entrez SP - 219 EP - 24 JF - The Journal of pediatrics JO - J Pediatr VL - 140 IS - 2 N2 - OBJECTIVES: We conducted a prospective, randomized study to evaluate the cumulative incidence of allergy or other adverse reactions to soy formula and to extensively hydrolyzed formula up to the age of 2 years in infants with confirmed cow's milk allergy. STUDY DESIGN: Infants (n = 170) with documented cow's milk allergy were randomly assigned to receive either a soy formula or an extensively hydrolyzed formula. If it was suspected that the formula caused symptoms, a double-blind, placebo-controlled challenge (DBPCFC) with the formula was performed. The children were followed to the age of 2 years, and soy-specific immunoglobulin E antibodies were measured at the time of diagnosis and at the ages of 1 and 2 years. RESULTS: An adverse reaction to the formula was confirmed by challenge in 8 patients (10%; 95% confidence interval, 4.4%-18.8%) randomly assigned to soy formula and in 2 patients (2.2%; 95% confidence interval, 0.3% to 7.8%) randomly assigned to extensively hydrolyzed formula. Adverse reactions to soy were similar in IgE-associated and non-IgE-associated cow's milk allergy (11% and 9%, respectively). IgE to soy was detected in only 2 infants with an adverse reaction to soy. Adverse reactions to soy formula were more common in younger (<6 months) than in older (6 to 12 months) infants (5 of 20 vs 3 of 60, respectively, P =.01). CONCLUSIONS: Soy formula was well tolerated by most infants with IgE-associated and non-IgE-associated cow's milk allergy. Development of IgE-associated allergy to soy was rare. Soy formula can be recommended as a first-choice alternative for infants >or=6 months of age with cow's milk allergy. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/11865274/Allergy_to_soy_formula_and_to_extensively_hydrolyzed_whey_formula_in_infants_with_cow's_milk_allergy:_a_prospective_randomized_study_with_a_follow_up_to_the_age_of_2_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(02)00281-0 DB - PRIME DP - Unbound Medicine ER -