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Treatment of long-distance intermittent claudication with pentoxifylline: a 12-month, randomized trial.
Angiology. 2002 Jan-Feb; 53 Suppl 1:S13-7.A

Abstract

The efficacy, safety, and cost of pentoxifylline (PXF) in long-range (>400 m interval) intermittent claudication was studied comparing PXF and placebo in a 12-month study. A standardized treadmill test was performed at inclusion and at 6 and 12 months. A training plan based on walking was associated with the control of risk factor levels. Of the 194 included patients, 135 completed the study: 75 in the PXF group and 60 in the placebo group. There were 59 dropouts (due to low compliance). The authors observed a 148% increase in total walking distance (TWD) at 6 months with PXF (vs 110% with placebo; p<0.05); at 12 months, the increase was 170% with PXF (vs 131% with placebo; p<0.02). There was a 38% difference at 6 months and 39% at 12 months in favor of PXF. Treatment was well tolerated. In conclusion, PXF improved walking distance significantly better than placebo.

Authors+Show Affiliations

Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Pe, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11865829

Citation

De Sanctis, M T., et al. "Treatment of Long-distance Intermittent Claudication With Pentoxifylline: a 12-month, Randomized Trial." Angiology, vol. 53 Suppl 1, 2002, pp. S13-7.
De Sanctis MT, Cesarone MR, Belcaro G, et al. Treatment of long-distance intermittent claudication with pentoxifylline: a 12-month, randomized trial. Angiology. 2002;53 Suppl 1:S13-7.
De Sanctis, M. T., Cesarone, M. R., Belcaro, G., Nicolaides, A. N., Griffin, M., Incandela, L., Bucci, M., Geroulakos, G., Ramaswami, G., Vasdekis, S., Agus, G., Bavera, P., & Ippolito, E. (2002). Treatment of long-distance intermittent claudication with pentoxifylline: a 12-month, randomized trial. Angiology, 53 Suppl 1, S13-7.
De Sanctis MT, et al. Treatment of Long-distance Intermittent Claudication With Pentoxifylline: a 12-month, Randomized Trial. Angiology. 2002 Jan-Feb;53 Suppl 1:S13-7. PubMed PMID: 11865829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of long-distance intermittent claudication with pentoxifylline: a 12-month, randomized trial. AU - De Sanctis,M T, AU - Cesarone,M R, AU - Belcaro,G, AU - Nicolaides,A N, AU - Griffin,M, AU - Incandela,L, AU - Bucci,M, AU - Geroulakos,G, AU - Ramaswami,G, AU - Vasdekis,S, AU - Agus,G, AU - Bavera,P, AU - Ippolito,E, PY - 2002/2/28/pubmed PY - 2002/3/22/medline PY - 2002/2/28/entrez SP - S13 EP - 7 JF - Angiology JO - Angiology VL - 53 Suppl 1 N2 - The efficacy, safety, and cost of pentoxifylline (PXF) in long-range (>400 m interval) intermittent claudication was studied comparing PXF and placebo in a 12-month study. A standardized treadmill test was performed at inclusion and at 6 and 12 months. A training plan based on walking was associated with the control of risk factor levels. Of the 194 included patients, 135 completed the study: 75 in the PXF group and 60 in the placebo group. There were 59 dropouts (due to low compliance). The authors observed a 148% increase in total walking distance (TWD) at 6 months with PXF (vs 110% with placebo; p<0.05); at 12 months, the increase was 170% with PXF (vs 131% with placebo; p<0.02). There was a 38% difference at 6 months and 39% at 12 months in favor of PXF. Treatment was well tolerated. In conclusion, PXF improved walking distance significantly better than placebo. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/11865829/Treatment_of_long_distance_intermittent_claudication_with_pentoxifylline:_a_12_month_randomized_trial_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=11865829.ui DB - PRIME DP - Unbound Medicine ER -