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Treatment of vascular inner ear disease in vascular patients with pentoxifylline: a controlled, randomized trial.
Angiology. 2002 Jan-Feb; 53 Suppl 1:S23-6.A

Abstract

The efficacy of Pentoxifylline in vascular inner ear disease (VIED) was studied comparing PXF and placebo in a 4-week study; 40 patients with vascular disease and monolateral loss of hearing, vertigo, dizziness, tinnitus (analyzed with an analogue scale line), and cochlear flow reduction were included. The aims of the study were to study the effects of PXF (1600 mg daily) in VIED considering clinical outcome and cochlear flow. Of the 20 included patients, 19 completed the study. One dropout in the placebo group was due to low compliance. Intention-to-treat analysis indicated an improvement in cochlear flow (p<0.05) and a decrease in score in both groups. The cochlear flow increase was 287.5% in the PXF group vs 168% in the placebo group (119.5% difference; p<0.02). There was a difference in score decrease (44.1% larger) in the PXF group (p<0.05).Between-group analysis favors PXF considering blood flow and symptoms. Results indicate good efficacy and tolerability of PXF in VIED.

Authors+Show Affiliations

Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Pe, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11865831

Citation

Cesarone, M R., et al. "Treatment of Vascular Inner Ear Disease in Vascular Patients With Pentoxifylline: a Controlled, Randomized Trial." Angiology, vol. 53 Suppl 1, 2002, pp. S23-6.
Cesarone MR, Incandela L, Belcaro G, et al. Treatment of vascular inner ear disease in vascular patients with pentoxifylline: a controlled, randomized trial. Angiology. 2002;53 Suppl 1:S23-6.
Cesarone, M. R., Incandela, L., Belcaro, G., De Sanctis, M. T., Nicolaides, A. N., Griffin, M., Geroulakos, G., & Ramaswami, G. (2002). Treatment of vascular inner ear disease in vascular patients with pentoxifylline: a controlled, randomized trial. Angiology, 53 Suppl 1, S23-6.
Cesarone MR, et al. Treatment of Vascular Inner Ear Disease in Vascular Patients With Pentoxifylline: a Controlled, Randomized Trial. Angiology. 2002 Jan-Feb;53 Suppl 1:S23-6. PubMed PMID: 11865831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of vascular inner ear disease in vascular patients with pentoxifylline: a controlled, randomized trial. AU - Cesarone,M R, AU - Incandela,L, AU - Belcaro,G, AU - De Sanctis,M T, AU - Nicolaides,A N, AU - Griffin,M, AU - Geroulakos,G, AU - Ramaswami,G, PY - 2002/2/28/pubmed PY - 2002/3/22/medline PY - 2002/2/28/entrez SP - S23 EP - 6 JF - Angiology JO - Angiology VL - 53 Suppl 1 N2 - The efficacy of Pentoxifylline in vascular inner ear disease (VIED) was studied comparing PXF and placebo in a 4-week study; 40 patients with vascular disease and monolateral loss of hearing, vertigo, dizziness, tinnitus (analyzed with an analogue scale line), and cochlear flow reduction were included. The aims of the study were to study the effects of PXF (1600 mg daily) in VIED considering clinical outcome and cochlear flow. Of the 20 included patients, 19 completed the study. One dropout in the placebo group was due to low compliance. Intention-to-treat analysis indicated an improvement in cochlear flow (p<0.05) and a decrease in score in both groups. The cochlear flow increase was 287.5% in the PXF group vs 168% in the placebo group (119.5% difference; p<0.02). There was a difference in score decrease (44.1% larger) in the PXF group (p<0.05).Between-group analysis favors PXF considering blood flow and symptoms. Results indicate good efficacy and tolerability of PXF in VIED. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/11865831/Treatment_of_vascular_inner_ear_disease_in_vascular_patients_with_pentoxifylline:_a_controlled_randomized_trial_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=11865831.ui DB - PRIME DP - Unbound Medicine ER -