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Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder.

Abstract

OBJECTIVE

Studies have reported that countries with high rates of fish oil consumption have low rates of depressive disorder. The authors studied a specific omega-3 fatty acid, the ethyl ester of eicosapentaenoic acid (E-EPA), as an adjunct to treatment for depressive episodes occurring in patients with recurrent unipolar depressive disorder who were receiving maintenance antidepressant therapy.

METHOD

Twenty patients with a current diagnosis of major depressive disorder participated in a 4-week, parallel-group, double-blind addition of either placebo or E-EPA to ongoing antidepressant therapy. Seventeen of the patients were women, and three were men.

RESULTS

Highly significant benefits of the addition of the omega-3 fatty acid compared with placebo were found by week 3 of treatment.

CONCLUSIONS

It is not possible to distinguish whether E-EPA augments antidepressant action in the manner of lithium or has independent antidepressant properties of its own.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.

    ,

    Source

    The American journal of psychiatry 159:3 2002 Mar pg 477-9

    MeSH

    Adult
    Aged
    Antidepressive Agents
    Depressive Disorder
    Double-Blind Method
    Drug Therapy, Combination
    Eicosapentaenoic Acid
    Fatty Acids, Omega-3
    Female
    Humans
    Male
    Middle Aged
    Patient Selection
    Placebos
    Research Design
    Secondary Prevention
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    11870016

    Citation

    Nemets, Boris, et al. "Addition of Omega-3 Fatty Acid to Maintenance Medication Treatment for Recurrent Unipolar Depressive Disorder." The American Journal of Psychiatry, vol. 159, no. 3, 2002, pp. 477-9.
    Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry. 2002;159(3):477-9.
    Nemets, B., Stahl, Z., & Belmaker, R. H. (2002). Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. The American Journal of Psychiatry, 159(3), pp. 477-9.
    Nemets B, Stahl Z, Belmaker RH. Addition of Omega-3 Fatty Acid to Maintenance Medication Treatment for Recurrent Unipolar Depressive Disorder. Am J Psychiatry. 2002;159(3):477-9. PubMed PMID: 11870016.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. AU - Nemets,Boris, AU - Stahl,Ziva, AU - Belmaker,R H, PY - 2002/3/1/pubmed PY - 2002/3/15/medline PY - 2002/3/1/entrez SP - 477 EP - 9 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 159 IS - 3 N2 - OBJECTIVE: Studies have reported that countries with high rates of fish oil consumption have low rates of depressive disorder. The authors studied a specific omega-3 fatty acid, the ethyl ester of eicosapentaenoic acid (E-EPA), as an adjunct to treatment for depressive episodes occurring in patients with recurrent unipolar depressive disorder who were receiving maintenance antidepressant therapy. METHOD: Twenty patients with a current diagnosis of major depressive disorder participated in a 4-week, parallel-group, double-blind addition of either placebo or E-EPA to ongoing antidepressant therapy. Seventeen of the patients were women, and three were men. RESULTS: Highly significant benefits of the addition of the omega-3 fatty acid compared with placebo were found by week 3 of treatment. CONCLUSIONS: It is not possible to distinguish whether E-EPA augments antidepressant action in the manner of lithium or has independent antidepressant properties of its own. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/11870016/full_citation L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.159.3.477?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -