Tags

Type your tag names separated by a space and hit enter

Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder.
Am J Psychiatry 2002; 159(3):477-9AJ

Abstract

OBJECTIVE

Studies have reported that countries with high rates of fish oil consumption have low rates of depressive disorder. The authors studied a specific omega-3 fatty acid, the ethyl ester of eicosapentaenoic acid (E-EPA), as an adjunct to treatment for depressive episodes occurring in patients with recurrent unipolar depressive disorder who were receiving maintenance antidepressant therapy.

METHOD

Twenty patients with a current diagnosis of major depressive disorder participated in a 4-week, parallel-group, double-blind addition of either placebo or E-EPA to ongoing antidepressant therapy. Seventeen of the patients were women, and three were men.

RESULTS

Highly significant benefits of the addition of the omega-3 fatty acid compared with placebo were found by week 3 of treatment.

CONCLUSIONS

It is not possible to distinguish whether E-EPA augments antidepressant action in the manner of lithium or has independent antidepressant properties of its own.

Authors+Show Affiliations

Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11870016

Citation

Nemets, Boris, et al. "Addition of Omega-3 Fatty Acid to Maintenance Medication Treatment for Recurrent Unipolar Depressive Disorder." The American Journal of Psychiatry, vol. 159, no. 3, 2002, pp. 477-9.
Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry. 2002;159(3):477-9.
Nemets, B., Stahl, Z., & Belmaker, R. H. (2002). Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. The American Journal of Psychiatry, 159(3), pp. 477-9.
Nemets B, Stahl Z, Belmaker RH. Addition of Omega-3 Fatty Acid to Maintenance Medication Treatment for Recurrent Unipolar Depressive Disorder. Am J Psychiatry. 2002;159(3):477-9. PubMed PMID: 11870016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. AU - Nemets,Boris, AU - Stahl,Ziva, AU - Belmaker,R H, PY - 2002/3/1/pubmed PY - 2002/3/15/medline PY - 2002/3/1/entrez SP - 477 EP - 9 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 159 IS - 3 N2 - OBJECTIVE: Studies have reported that countries with high rates of fish oil consumption have low rates of depressive disorder. The authors studied a specific omega-3 fatty acid, the ethyl ester of eicosapentaenoic acid (E-EPA), as an adjunct to treatment for depressive episodes occurring in patients with recurrent unipolar depressive disorder who were receiving maintenance antidepressant therapy. METHOD: Twenty patients with a current diagnosis of major depressive disorder participated in a 4-week, parallel-group, double-blind addition of either placebo or E-EPA to ongoing antidepressant therapy. Seventeen of the patients were women, and three were men. RESULTS: Highly significant benefits of the addition of the omega-3 fatty acid compared with placebo were found by week 3 of treatment. CONCLUSIONS: It is not possible to distinguish whether E-EPA augments antidepressant action in the manner of lithium or has independent antidepressant properties of its own. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/11870016/full_citation L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.159.3.477?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -