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Yellow fever: an update.
Lancet Infect Dis. 2001 Aug; 1(1):11-20.LI

Abstract

Yellow fever, the original viral haemorrhagic fever, was one of the most feared lethal diseases before the development of an effective vaccine. Today the disease still affects as many as 200,000 persons annually in tropical regions of Africa and South America, and poses a significant hazard to unvaccinated travellers to these areas. Yellow fever is transmitted in a cycle involving monkeys and mosquitoes, but human beings can also serve as the viraemic host for mosquito infection. Recent increases in the density and distribution of the urban mosquito vector, Aedes aegypti, as well as the rise in air travel increase the risk of introduction and spread of yellow fever to North and Central America, the Caribbean and Asia. Here I review the clinical features of the disease, its pathogenesis and pathophysiology. The disease mechanisms are poorly understood and have not been the subject of modern clinical research. Since there is no specific treatment, and management of patients with the disease is extremely problematic, the emphasis is on preventative vaccination. As a zoonosis, yellow fever cannot be eradicated, but reduction of the human disease burden is achievable through routine childhood vaccination in endemic countries, with a low cost for the benefits obtained. The biological characteristics, safety, and efficacy of live attenuated, yellow fever 17D vaccine are reviewed. New applications of yellow fever 17D virus as a vector for foreign genes hold considerable promise as a means of developing new vaccines against other viruses, and possibly against cancers.

Authors+Show Affiliations

Acambis Inc, Cambridge, Massachusetts 02139, USA. thomas.monath@acambis.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11871403

Citation

Monath, T P.. "Yellow Fever: an Update." The Lancet. Infectious Diseases, vol. 1, no. 1, 2001, pp. 11-20.
Monath TP. Yellow fever: an update. Lancet Infect Dis. 2001;1(1):11-20.
Monath, T. P. (2001). Yellow fever: an update. The Lancet. Infectious Diseases, 1(1), 11-20.
Monath TP. Yellow Fever: an Update. Lancet Infect Dis. 2001;1(1):11-20. PubMed PMID: 11871403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Yellow fever: an update. A1 - Monath,T P, PY - 2002/3/2/pubmed PY - 2002/3/7/medline PY - 2002/3/2/entrez SP - 11 EP - 20 JF - The Lancet. Infectious diseases JO - Lancet Infect Dis VL - 1 IS - 1 N2 - Yellow fever, the original viral haemorrhagic fever, was one of the most feared lethal diseases before the development of an effective vaccine. Today the disease still affects as many as 200,000 persons annually in tropical regions of Africa and South America, and poses a significant hazard to unvaccinated travellers to these areas. Yellow fever is transmitted in a cycle involving monkeys and mosquitoes, but human beings can also serve as the viraemic host for mosquito infection. Recent increases in the density and distribution of the urban mosquito vector, Aedes aegypti, as well as the rise in air travel increase the risk of introduction and spread of yellow fever to North and Central America, the Caribbean and Asia. Here I review the clinical features of the disease, its pathogenesis and pathophysiology. The disease mechanisms are poorly understood and have not been the subject of modern clinical research. Since there is no specific treatment, and management of patients with the disease is extremely problematic, the emphasis is on preventative vaccination. As a zoonosis, yellow fever cannot be eradicated, but reduction of the human disease burden is achievable through routine childhood vaccination in endemic countries, with a low cost for the benefits obtained. The biological characteristics, safety, and efficacy of live attenuated, yellow fever 17D vaccine are reviewed. New applications of yellow fever 17D virus as a vector for foreign genes hold considerable promise as a means of developing new vaccines against other viruses, and possibly against cancers. SN - 1473-3099 UR - https://www.unboundmedicine.com/medline/citation/11871403/Yellow_fever:_an_update_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1473-3099(01)00016-0 DB - PRIME DP - Unbound Medicine ER -