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Low antroduodenal pressure gradients are responsible for gastric emptying of a low-caloric liquid meal in humans.
Neurogastroenterol Motil. 2002 Feb; 14(1):97-105.NM

Abstract

The motor mechanisms responsible for transpyloric flow of gastric contents are still poorly understood. The aim of our study was to investigate the relationship between luminal pressures and gastric wall motion and between gastroduodenal pressure gradients and pressure waves, and ante- and retro-grade transpyloric flow. In eight healthy volunteers, intraluminal pressures were recorded from the antrum and proximal duodenum. Transpyloric flow was monitored simultaneously using duplex ultrasonography, before, during and after ingestion of 300 mL meat soup. Transpyloric emptying occurred as sequences of alternating periods of emptying-reflux-emptying. Approximately one-third of the sequences were not associated with peristalsis. The antroduodenal pressure gradients were significantly lower during nonperistaltic-related emptying than during peristaltic-related emptying (0.15 (0-0.3) kPa, and 1.7 (0.2-2.0) kPa, respectively [mean plus minus (range)], P < 0.005). The duration of emptying episodes not associated with peristalsis were significantly longer than those associated with peristalsis at (6.5 (3-8.7) s and 4.4 (2-6) s, respectively, P=0.059). Manometry detected only 56% of the antral contractions seen on ultrasound. We concluded that gastric emptying of a low-calorie liquid meal occurs both during peristaltic and nonperistaltic antral activity. In spite of lower antroduodenal pressure gradients, the emptying episodes were longer for nonperistaltic emptying, which is likely to be caused by low pyloric resistance. Considerable flow seems to occur without peristalsis during gastric emptying of a low-calorie, liquid meal in humans.

Authors+Show Affiliations

Division of Gastroenterology, Medical Department, Haukeland University Hospital, Bergen, Norway. tryh@haukeland.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11874558

Citation

Hausken, T, et al. "Low Antroduodenal Pressure Gradients Are Responsible for Gastric Emptying of a Low-caloric Liquid Meal in Humans." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 14, no. 1, 2002, pp. 97-105.
Hausken T, Mundt M, Samsom M. Low antroduodenal pressure gradients are responsible for gastric emptying of a low-caloric liquid meal in humans. Neurogastroenterol Motil. 2002;14(1):97-105.
Hausken, T., Mundt, M., & Samsom, M. (2002). Low antroduodenal pressure gradients are responsible for gastric emptying of a low-caloric liquid meal in humans. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 14(1), 97-105.
Hausken T, Mundt M, Samsom M. Low Antroduodenal Pressure Gradients Are Responsible for Gastric Emptying of a Low-caloric Liquid Meal in Humans. Neurogastroenterol Motil. 2002;14(1):97-105. PubMed PMID: 11874558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low antroduodenal pressure gradients are responsible for gastric emptying of a low-caloric liquid meal in humans. AU - Hausken,T, AU - Mundt,M, AU - Samsom,M, PY - 2002/3/5/pubmed PY - 2002/5/25/medline PY - 2002/3/5/entrez SP - 97 EP - 105 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol Motil VL - 14 IS - 1 N2 - The motor mechanisms responsible for transpyloric flow of gastric contents are still poorly understood. The aim of our study was to investigate the relationship between luminal pressures and gastric wall motion and between gastroduodenal pressure gradients and pressure waves, and ante- and retro-grade transpyloric flow. In eight healthy volunteers, intraluminal pressures were recorded from the antrum and proximal duodenum. Transpyloric flow was monitored simultaneously using duplex ultrasonography, before, during and after ingestion of 300 mL meat soup. Transpyloric emptying occurred as sequences of alternating periods of emptying-reflux-emptying. Approximately one-third of the sequences were not associated with peristalsis. The antroduodenal pressure gradients were significantly lower during nonperistaltic-related emptying than during peristaltic-related emptying (0.15 (0-0.3) kPa, and 1.7 (0.2-2.0) kPa, respectively [mean plus minus (range)], P < 0.005). The duration of emptying episodes not associated with peristalsis were significantly longer than those associated with peristalsis at (6.5 (3-8.7) s and 4.4 (2-6) s, respectively, P=0.059). Manometry detected only 56% of the antral contractions seen on ultrasound. We concluded that gastric emptying of a low-calorie liquid meal occurs both during peristaltic and nonperistaltic antral activity. In spite of lower antroduodenal pressure gradients, the emptying episodes were longer for nonperistaltic emptying, which is likely to be caused by low pyloric resistance. Considerable flow seems to occur without peristalsis during gastric emptying of a low-calorie, liquid meal in humans. SN - 1350-1925 UR - https://www.unboundmedicine.com/medline/citation/11874558/Low_antroduodenal_pressure_gradients_are_responsible_for_gastric_emptying_of_a_low_caloric_liquid_meal_in_humans_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1350-1925&amp;date=2002&amp;volume=14&amp;issue=1&amp;spage=97 DB - PRIME DP - Unbound Medicine ER -