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[Immunorelated pancytopenia].
Zhonghua Xue Ye Xue Za Zhi. 2001 Feb; 22(2):79-82.ZX

Abstract

OBJECTIVE

A report of a group of patients with pancytopenia which might be related to abnormal immunity.

METHODS

The clinical and laboratory features of 29 patients with positive bone marrow mononuclear cell (BMMNC) Coombs tests were analyzed.

RESULTS

Most of these cases were pancytopenia with normal or decreased bone marrow cellularities and increased normoblasts. They were all found to have negative results of conventional hemolysis tests and hematopoietic nutrient determination and had no evidence of malignant clonal hematopoiesis. However, all of them showed positive BMMNC-Coombs test and good response to corticosteroids.

CONCLUSION

Immunorelated pancytopenia might be caused by abnormal immunity (especially autoantibody) mediated destruction or abnormal function of blood cells. It is beneficial to differentiate immunorelated pancytopenia from aplastic anemia or myelodysplastic syndromes.

Authors+Show Affiliations

He H
Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.
Shao Z
No affiliation info available
Liu H
No affiliation info available
Song L
No affiliation info available
Tian P
No affiliation info available
Cao Z
No affiliation info available
Zhang Y
No affiliation info available
Li K
No affiliation info available
Zhao M
No affiliation info available
Shi J
No affiliation info available
He G
No affiliation info available
Chu Y
No affiliation info available
Qian L
No affiliation info available
Yang T
No affiliation info available

MeSH

AdolescentAdultBone Marrow CellsCells, CulturedChildCoombs TestFemaleHematopoiesisHumansMaleMiddle AgedPancytopeniaYoung Adult

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11877054

Citation

He, H, et al. "[Immunorelated Pancytopenia]." Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, vol. 22, no. 2, 2001, pp. 79-82.
He H, Shao Z, Liu H, et al. [Immunorelated pancytopenia]. Zhonghua Xue Ye Xue Za Zhi. 2001;22(2):79-82.
He, H., Shao, Z., Liu, H., Song, L., Tian, P., Cao, Z., Zhang, Y., Li, K., Zhao, M., Shi, J., He, G., Chu, Y., Qian, L., & Yang, T. (2001). [Immunorelated pancytopenia]. Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 22(2), 79-82.
He H, et al. [Immunorelated Pancytopenia]. Zhonghua Xue Ye Xue Za Zhi. 2001;22(2):79-82. PubMed PMID: 11877054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immunorelated pancytopenia]. AU - He,H, AU - Shao,Z, AU - Liu,H, AU - Song,L, AU - Tian,P, AU - Cao,Z, AU - Zhang,Y, AU - Li,K, AU - Zhao,M, AU - Shi,J, AU - He,G, AU - Chu,Y, AU - Qian,L, AU - Yang,T, PY - 2002/3/6/pubmed PY - 2010/5/26/medline PY - 2002/3/6/entrez SP - 79 EP - 82 JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi JO - Zhonghua Xue Ye Xue Za Zhi VL - 22 IS - 2 N2 - OBJECTIVE: A report of a group of patients with pancytopenia which might be related to abnormal immunity. METHODS: The clinical and laboratory features of 29 patients with positive bone marrow mononuclear cell (BMMNC) Coombs tests were analyzed. RESULTS: Most of these cases were pancytopenia with normal or decreased bone marrow cellularities and increased normoblasts. They were all found to have negative results of conventional hemolysis tests and hematopoietic nutrient determination and had no evidence of malignant clonal hematopoiesis. However, all of them showed positive BMMNC-Coombs test and good response to corticosteroids. CONCLUSION: Immunorelated pancytopenia might be caused by abnormal immunity (especially autoantibody) mediated destruction or abnormal function of blood cells. It is beneficial to differentiate immunorelated pancytopenia from aplastic anemia or myelodysplastic syndromes. SN - 0253-2727 UR - https://www.unboundmedicine.com/medline/citation/11877054/[Immunorelated_pancytopenia]_ DB - PRIME DP - Unbound Medicine ER -