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Anticonvulsant activity of four oxygenated cannabidiol derivatives.
Res Commun Chem Pathol Pharmacol. 1975 Sep; 12(1):1-15.RC

Abstract

A pharmacological comparison between cannabidiol (CBD) and four CBD derivatives, namely CBD-aldehyde-diacetate (I), 6-oxo-CBD-diacetate (II), 6-hydroxy-CBD-tri-acetate (III), and 9-hydroxy-CBD-triacetate (IV) was carried out in mice. Protection against maximal electroshock convulsions, potentiation of pentobarbital sleeping-time and reduction of spontaneous motor activity were the effects measured. All 5 compounds were equally potent in potentiating barbiturate sleeping time at doses ranging from 6.25 to 100 mg/kg. At 12.5 and 25 mg/kg only CBD and IV were able to decrease significantly the spontaneous motor activity. CBD, II, III and IV were also active in protecting mice against electroconvulsive shock at doses of 100-200 mg/kg, although at the larger dose CBD and compound II were the most efficient. Compound I was toxic, killing about half of the animals within 24 h after injection.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1188178

Citation

Carlini, E A., et al. "Anticonvulsant Activity of Four Oxygenated Cannabidiol Derivatives." Research Communications in Chemical Pathology and Pharmacology, vol. 12, no. 1, 1975, pp. 1-15.
Carlini EA, Mechoulam R, Lander N. Anticonvulsant activity of four oxygenated cannabidiol derivatives. Res Commun Chem Pathol Pharmacol. 1975;12(1):1-15.
Carlini, E. A., Mechoulam, R., & Lander, N. (1975). Anticonvulsant activity of four oxygenated cannabidiol derivatives. Research Communications in Chemical Pathology and Pharmacology, 12(1), 1-15.
Carlini EA, Mechoulam R, Lander N. Anticonvulsant Activity of Four Oxygenated Cannabidiol Derivatives. Res Commun Chem Pathol Pharmacol. 1975;12(1):1-15. PubMed PMID: 1188178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anticonvulsant activity of four oxygenated cannabidiol derivatives. AU - Carlini,E A, AU - Mechoulam,R, AU - Lander,N, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 1 EP - 15 JF - Research communications in chemical pathology and pharmacology JO - Res Commun Chem Pathol Pharmacol VL - 12 IS - 1 N2 - A pharmacological comparison between cannabidiol (CBD) and four CBD derivatives, namely CBD-aldehyde-diacetate (I), 6-oxo-CBD-diacetate (II), 6-hydroxy-CBD-tri-acetate (III), and 9-hydroxy-CBD-triacetate (IV) was carried out in mice. Protection against maximal electroshock convulsions, potentiation of pentobarbital sleeping-time and reduction of spontaneous motor activity were the effects measured. All 5 compounds were equally potent in potentiating barbiturate sleeping time at doses ranging from 6.25 to 100 mg/kg. At 12.5 and 25 mg/kg only CBD and IV were able to decrease significantly the spontaneous motor activity. CBD, II, III and IV were also active in protecting mice against electroconvulsive shock at doses of 100-200 mg/kg, although at the larger dose CBD and compound II were the most efficient. Compound I was toxic, killing about half of the animals within 24 h after injection. SN - 0034-5164 UR - https://www.unboundmedicine.com/medline/citation/1188178/Anticonvulsant_activity_of_four_oxygenated_cannabidiol_derivatives_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:1188178 DB - PRIME DP - Unbound Medicine ER -