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Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats.
Indian J Physiol Pharmacol. 2001 Oct; 45(4):408-20.IJ

Abstract

The influence of fenugreek seed powder supplementation in the diet on lipid peroxidation and antioxidant status was studied in normal and alloxan-diabetic rats. The protective effect of the aqueous extract of the seeds on the activity of calcium-dependent adenosinetriphosphatase (Ca2+ ATPase) in liver homogenate in the presence of Fe2+/ascorbate in vitro was also investigated. Normal and diabetic rats were provided with a diet supplemented with fenugreek seed powder for 30 days at a dosage of 2 g/kg body weight. The diabetic rats exhibited enhanced lipid peroxidation and increased susceptibility to oxidative stress associated with depletion of antioxidants in liver, kidney and pancreas. However, treatment with fenugreek seed powder normalised the alterations. In normal rats supplementation resulted in increased antioxidant status with reduction in peroxidation. Ca2+ ATPase activity in liver was protected by the aqueous extract to nearly 80% of the initial activity. The findings suggest that the soluble portion of the seeds could be responsible for the antioxidant property.

Authors+Show Affiliations

Department of Biochemistry, Annamalai University, Annamalainagar-608 002.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11883146

Citation

Anuradha, C V., and P Ravikumar. "Restoration On Tissue Antioxidants By Fenugreek Seeds (Trigonella Foenum Graecum) in Alloxan-diabetic Rats." Indian Journal of Physiology and Pharmacology, vol. 45, no. 4, 2001, pp. 408-20.
Anuradha CV, Ravikumar P. Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats. Indian J Physiol Pharmacol. 2001;45(4):408-20.
Anuradha, C. V., & Ravikumar, P. (2001). Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats. Indian Journal of Physiology and Pharmacology, 45(4), 408-20.
Anuradha CV, Ravikumar P. Restoration On Tissue Antioxidants By Fenugreek Seeds (Trigonella Foenum Graecum) in Alloxan-diabetic Rats. Indian J Physiol Pharmacol. 2001;45(4):408-20. PubMed PMID: 11883146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats. AU - Anuradha,C V, AU - Ravikumar,P, PY - 2002/3/9/pubmed PY - 2002/8/17/medline PY - 2002/3/9/entrez SP - 408 EP - 20 JF - Indian journal of physiology and pharmacology JO - Indian J Physiol Pharmacol VL - 45 IS - 4 N2 - The influence of fenugreek seed powder supplementation in the diet on lipid peroxidation and antioxidant status was studied in normal and alloxan-diabetic rats. The protective effect of the aqueous extract of the seeds on the activity of calcium-dependent adenosinetriphosphatase (Ca2+ ATPase) in liver homogenate in the presence of Fe2+/ascorbate in vitro was also investigated. Normal and diabetic rats were provided with a diet supplemented with fenugreek seed powder for 30 days at a dosage of 2 g/kg body weight. The diabetic rats exhibited enhanced lipid peroxidation and increased susceptibility to oxidative stress associated with depletion of antioxidants in liver, kidney and pancreas. However, treatment with fenugreek seed powder normalised the alterations. In normal rats supplementation resulted in increased antioxidant status with reduction in peroxidation. Ca2+ ATPase activity in liver was protected by the aqueous extract to nearly 80% of the initial activity. The findings suggest that the soluble portion of the seeds could be responsible for the antioxidant property. SN - 0019-5499 UR - https://www.unboundmedicine.com/medline/citation/11883146/Restoration_on_tissue_antioxidants_by_fenugreek_seeds__Trigonella_Foenum_Graecum__in_alloxan_diabetic_rats_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -