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Combination of recombinant human growth hormone and glutamine-enriched total parenteral nutrition to surgical patients: effects on circulating amino acids.
Clin Nutr. 2001 Dec; 20(6):503-10.CN

Abstract

BACKGROUND & AIMS

Both recombinant human growth hormone (rhGH) and glutamine (GLN) may have beneficial anabolic actions on amino acid metabolism. The aim of this study was to evaluate the additive effects of rhGH and GLN on plasma amino acids postoperatively.

METHODS

31 females undergoing laparoscopic cholecystectomy were randomized to three groups: Group I (n=10) received 13 IU/m(2) of rhGH the morning of surgery and the following three postoperative days, together with glutamine-free TPN for the first two postoperative days. Group II (n=11) received rhGH as the first group, together with glutamine-enriched (7 g GLN/m(2)/day) TPN. Group III (n=10) received glutamine-enriched TPN as the second group, but rhGH was replaced by placebo. Daily plasma amino acid concentrations and nitrogen balance were determined.

RESULTS

In the GH treated groups, the plasma concentrations of several amino acids were decreased on the third postoperative day, compared to preoperatively. This was not observed in Group III. The changes were more pronounced in Group II. In Group II the negative AV-differences of amino acids tended to be attenuated, while the patients in Group III had increased negative AV-differences. The cumulative nitrogen balance was significantly improved in the GH groups, compared with Group III.

CONCLUSION

The combined treatment of growth hormone and glutamine has additive effects on AV-balances of amino acids postoperatively, whereas nitrogen balance is not further improved when adding glutamine to rhGH treatment.

Authors+Show Affiliations

Department of Digestive Surgery, Trømso University Hospital, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11883998

Citation

Kolstad, O, et al. "Combination of Recombinant Human Growth Hormone and Glutamine-enriched Total Parenteral Nutrition to Surgical Patients: Effects On Circulating Amino Acids." Clinical Nutrition (Edinburgh, Scotland), vol. 20, no. 6, 2001, pp. 503-10.
Kolstad O, Jenssen TG, Ingebretsen OC, et al. Combination of recombinant human growth hormone and glutamine-enriched total parenteral nutrition to surgical patients: effects on circulating amino acids. Clin Nutr. 2001;20(6):503-10.
Kolstad, O., Jenssen, T. G., Ingebretsen, O. C., Vinnars, E., & Revhaug, A. (2001). Combination of recombinant human growth hormone and glutamine-enriched total parenteral nutrition to surgical patients: effects on circulating amino acids. Clinical Nutrition (Edinburgh, Scotland), 20(6), 503-10.
Kolstad O, et al. Combination of Recombinant Human Growth Hormone and Glutamine-enriched Total Parenteral Nutrition to Surgical Patients: Effects On Circulating Amino Acids. Clin Nutr. 2001;20(6):503-10. PubMed PMID: 11883998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of recombinant human growth hormone and glutamine-enriched total parenteral nutrition to surgical patients: effects on circulating amino acids. AU - Kolstad,O, AU - Jenssen,T G, AU - Ingebretsen,O C, AU - Vinnars,E, AU - Revhaug,A, PY - 2002/3/9/pubmed PY - 2002/6/26/medline PY - 2002/3/9/entrez SP - 503 EP - 10 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 20 IS - 6 N2 - BACKGROUND & AIMS: Both recombinant human growth hormone (rhGH) and glutamine (GLN) may have beneficial anabolic actions on amino acid metabolism. The aim of this study was to evaluate the additive effects of rhGH and GLN on plasma amino acids postoperatively. METHODS: 31 females undergoing laparoscopic cholecystectomy were randomized to three groups: Group I (n=10) received 13 IU/m(2) of rhGH the morning of surgery and the following three postoperative days, together with glutamine-free TPN for the first two postoperative days. Group II (n=11) received rhGH as the first group, together with glutamine-enriched (7 g GLN/m(2)/day) TPN. Group III (n=10) received glutamine-enriched TPN as the second group, but rhGH was replaced by placebo. Daily plasma amino acid concentrations and nitrogen balance were determined. RESULTS: In the GH treated groups, the plasma concentrations of several amino acids were decreased on the third postoperative day, compared to preoperatively. This was not observed in Group III. The changes were more pronounced in Group II. In Group II the negative AV-differences of amino acids tended to be attenuated, while the patients in Group III had increased negative AV-differences. The cumulative nitrogen balance was significantly improved in the GH groups, compared with Group III. CONCLUSION: The combined treatment of growth hormone and glutamine has additive effects on AV-balances of amino acids postoperatively, whereas nitrogen balance is not further improved when adding glutamine to rhGH treatment. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/11883998/Combination_of_recombinant_human_growth_hormone_and_glutamine_enriched_total_parenteral_nutrition_to_surgical_patients:_effects_on_circulating_amino_acids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(01)90478-9 DB - PRIME DP - Unbound Medicine ER -