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Diagnosis and treatment of isolated neck metastases of adenocarcinomas.
Eur J Surg Oncol. 2002 Mar; 28(2):147-52.EJ

Abstract

AIMS

Cervical metastases of adenocarcinoma or undifferentiated large cell carcinoma (ULCC) (non-squamous cell carcinoma) of unknown primary origin are rare and often accompanied by distant metastases at multiple sites in the body. Nevertheless, in the past decades, several patients have presented in our clinic with isolated neck metastases of this type of malignancy. The aim of our study is to evaluate the clinical behaviour of these cases and to define the role of surgery and radiotherapy.

METHODS

Over the past 24 years, we selected 15 out of 270 patients (6%) with isolated cervical lymph node metastases of adenocarcinoma (six) or ULCC (nine) of unknown primary origin. Diagnosis was made either by histology or by fine needle aspiration cytology. Treatment consisted of (selective) neck dissection and/or radiotherapy.

RESULTS

The clinical presentation of isolated cervical metastases of adenocarcinoma compared with ULCC is equivalent, with an overall median survival time of 25 months (confidence interval 21--29 months). Combined therapy was correlated with an increased and persistent regional control and was associated with longer duration of survival.

CONCLUSIONS

Patients with isolated cervical neck node metastases of adenocarcinoma or ULCC of unknown primary origin are rare and the diagnostic process to identify this subgroup requires a systemic work-up. In selected cases treatment should concentrate on (selective) neck dissection combined with radiotherapy to achieve a prolonged survival.

Authors+Show Affiliations

Department of Head and Neck Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11884050

Citation

Zuur, C L., et al. "Diagnosis and Treatment of Isolated Neck Metastases of Adenocarcinomas." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 28, no. 2, 2002, pp. 147-52.
Zuur CL, van Velthuysen ML, Schornagel JH, et al. Diagnosis and treatment of isolated neck metastases of adenocarcinomas. Eur J Surg Oncol. 2002;28(2):147-52.
Zuur, C. L., van Velthuysen, M. L., Schornagel, J. H., Hilgers, F. J., & Balm, A. J. (2002). Diagnosis and treatment of isolated neck metastases of adenocarcinomas. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 28(2), 147-52.
Zuur CL, et al. Diagnosis and Treatment of Isolated Neck Metastases of Adenocarcinomas. Eur J Surg Oncol. 2002;28(2):147-52. PubMed PMID: 11884050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and treatment of isolated neck metastases of adenocarcinomas. AU - Zuur,C L, AU - van Velthuysen,M L, AU - Schornagel,J H, AU - Hilgers,F J, AU - Balm,A J, PY - 2002/3/9/pubmed PY - 2002/5/9/medline PY - 2002/3/9/entrez SP - 147 EP - 52 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 28 IS - 2 N2 - AIMS: Cervical metastases of adenocarcinoma or undifferentiated large cell carcinoma (ULCC) (non-squamous cell carcinoma) of unknown primary origin are rare and often accompanied by distant metastases at multiple sites in the body. Nevertheless, in the past decades, several patients have presented in our clinic with isolated neck metastases of this type of malignancy. The aim of our study is to evaluate the clinical behaviour of these cases and to define the role of surgery and radiotherapy. METHODS: Over the past 24 years, we selected 15 out of 270 patients (6%) with isolated cervical lymph node metastases of adenocarcinoma (six) or ULCC (nine) of unknown primary origin. Diagnosis was made either by histology or by fine needle aspiration cytology. Treatment consisted of (selective) neck dissection and/or radiotherapy. RESULTS: The clinical presentation of isolated cervical metastases of adenocarcinoma compared with ULCC is equivalent, with an overall median survival time of 25 months (confidence interval 21--29 months). Combined therapy was correlated with an increased and persistent regional control and was associated with longer duration of survival. CONCLUSIONS: Patients with isolated cervical neck node metastases of adenocarcinoma or ULCC of unknown primary origin are rare and the diagnostic process to identify this subgroup requires a systemic work-up. In selected cases treatment should concentrate on (selective) neck dissection combined with radiotherapy to achieve a prolonged survival. SN - 0748-7983 UR - https://www.unboundmedicine.com/medline/citation/11884050/Diagnosis_and_treatment_of_isolated_neck_metastases_of_adenocarcinomas_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0748798301912223 DB - PRIME DP - Unbound Medicine ER -