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Medical treatment of osteoporosis--increasing options.
Ann Acad Med Singapore 2002; 31(1):43-7AA

Abstract

INTRODUCTION

Many drugs are now available for the prevention and treatment of osteoporosis. They have differing levels of evidence of efficacy and each may be used according to clinical indications.

METHODS

A Medline search of clinical drug trials using various therapeutic agents used for osteoporosis was carried out.

RESULTS

Several randomised controlled trials have been carried out using many agents. The agents with the best data to date with regards to the prevention of spine as well as hip fractures in patients with prevalent fractures belong to alendronate and risedronate. Parathyroid hormone has been shown in one trial to reduce the risk of non-vertebral fractures. For reduction of spine fractures, in addition to the above two bisphosphonates, many agents, in particular raloxifene, have been shown to be clearly beneficial. Weaker data exist for hormone replacement, calcitonin, cyclical etidronate and the vitamin D analogues calcitriol and alfacalcidol.

CONCLUSION

There are many therapeutic agents shown to be clearly effective in the treatment of osteoporosis.

Authors+Show Affiliations

Gleneagles Medical Center, 6 Napier Road, #04-18, Singapore 258499.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11885495

Citation

Leong, K H.. "Medical Treatment of Osteoporosis--increasing Options." Annals of the Academy of Medicine, Singapore, vol. 31, no. 1, 2002, pp. 43-7.
Leong KH. Medical treatment of osteoporosis--increasing options. Ann Acad Med Singap. 2002;31(1):43-7.
Leong, K. H. (2002). Medical treatment of osteoporosis--increasing options. Annals of the Academy of Medicine, Singapore, 31(1), pp. 43-7.
Leong KH. Medical Treatment of Osteoporosis--increasing Options. Ann Acad Med Singap. 2002;31(1):43-7. PubMed PMID: 11885495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medical treatment of osteoporosis--increasing options. A1 - Leong,K H, PY - 2002/3/12/pubmed PY - 2002/8/23/medline PY - 2002/3/12/entrez SP - 43 EP - 7 JF - Annals of the Academy of Medicine, Singapore JO - Ann. Acad. Med. Singap. VL - 31 IS - 1 N2 - INTRODUCTION: Many drugs are now available for the prevention and treatment of osteoporosis. They have differing levels of evidence of efficacy and each may be used according to clinical indications. METHODS: A Medline search of clinical drug trials using various therapeutic agents used for osteoporosis was carried out. RESULTS: Several randomised controlled trials have been carried out using many agents. The agents with the best data to date with regards to the prevention of spine as well as hip fractures in patients with prevalent fractures belong to alendronate and risedronate. Parathyroid hormone has been shown in one trial to reduce the risk of non-vertebral fractures. For reduction of spine fractures, in addition to the above two bisphosphonates, many agents, in particular raloxifene, have been shown to be clearly beneficial. Weaker data exist for hormone replacement, calcitonin, cyclical etidronate and the vitamin D analogues calcitriol and alfacalcidol. CONCLUSION: There are many therapeutic agents shown to be clearly effective in the treatment of osteoporosis. SN - 0304-4602 UR - https://www.unboundmedicine.com/medline/citation/11885495/Medical_treatment_of_osteoporosis__increasing_options_ L2 - http://www.diseaseinfosearch.org/result/9059 DB - PRIME DP - Unbound Medicine ER -