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Reversible myelopathy in a 34-year-old man with vitamin B12 deficiency.
Mayo Clin Proc. 2002 Mar; 77(3):291-4.MC

Abstract

Vitamin B12 deficiency is common, with most patients lacking classic features of advanced severe deficiency. Early diagnosis and treatment prevent severe anemia and irreversible damage to the nervous system. We describe a 34-year-old man with pernicious anemia who presented with clinical and radiologic features of early myelopathy and borderline low serum levels of vitamin B12. Prompt diagnosis based on the measurement of serum methylmalonic acid and treatment with cyanocobalamin injections led to rapid resolution of clinical manifestations and magnetic resonance imaging abnormalities. We review the literature of magnetic resonance imaging in vitamin B12 deficiency myelopathy and discuss the issues relating to diagnosis and early treatment of this potentially reversible condition.

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Authors+Show Affiliations

Pittock SJ
Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA. pittock.sean@mayo.edu
Payne TA
No affiliation info available
Harper CM
No affiliation info available

MeSH

AdultDiagnosis, DifferentialHumansMagnetic Resonance ImagingMaleMethylmalonic AcidParesthesiaSpinal Cord DiseasesTime FactorsTreatment OutcomeVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11888035

Citation

Pittock, Sean J., et al. "Reversible Myelopathy in a 34-year-old Man With Vitamin B12 Deficiency." Mayo Clinic Proceedings, vol. 77, no. 3, 2002, pp. 291-4.
Pittock SJ, Payne TA, Harper CM. Reversible myelopathy in a 34-year-old man with vitamin B12 deficiency. Mayo Clin Proc. 2002;77(3):291-4.
Pittock, S. J., Payne, T. A., & Harper, C. M. (2002). Reversible myelopathy in a 34-year-old man with vitamin B12 deficiency. Mayo Clinic Proceedings, 77(3), 291-4.
Pittock SJ, Payne TA, Harper CM. Reversible Myelopathy in a 34-year-old Man With Vitamin B12 Deficiency. Mayo Clin Proc. 2002;77(3):291-4. PubMed PMID: 11888035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reversible myelopathy in a 34-year-old man with vitamin B12 deficiency. AU - Pittock,Sean J, AU - Payne,Troy A, AU - Harper,C Michel, PY - 2002/3/13/pubmed PY - 2002/3/28/medline PY - 2002/3/13/entrez SP - 291 EP - 4 JF - Mayo Clinic proceedings JO - Mayo Clin Proc VL - 77 IS - 3 N2 - Vitamin B12 deficiency is common, with most patients lacking classic features of advanced severe deficiency. Early diagnosis and treatment prevent severe anemia and irreversible damage to the nervous system. We describe a 34-year-old man with pernicious anemia who presented with clinical and radiologic features of early myelopathy and borderline low serum levels of vitamin B12. Prompt diagnosis based on the measurement of serum methylmalonic acid and treatment with cyanocobalamin injections led to rapid resolution of clinical manifestations and magnetic resonance imaging abnormalities. We review the literature of magnetic resonance imaging in vitamin B12 deficiency myelopathy and discuss the issues relating to diagnosis and early treatment of this potentially reversible condition. SN - 0025-6196 UR - https://www.unboundmedicine.com/medline/citation/11888035/Reversible_myelopathy_in_a_34_year_old_man_with_vitamin_B12_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(11)62363-X DB - PRIME DP - Unbound Medicine ER -