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An extensively hydrolysed cow's milk formula improves clinical symptoms of gastroesophageal reflux and reduces the gastric emptying time in infants.
Allergol Immunopathol (Madr). 2002 Jan-Feb; 30(1):36-41.AI

Abstract

BACKGROUND

About 20 % of infants fed with breast-milk substitutes suffer from Gastro Esophageal Reflux (GER) and 1/3 of them also show Cow's Milk Allergy (CMA) symptoms.

METHODS

We planned this study to assess by dynamic echography the usefulness of an Extensively Hydrolysed Cow's Milk Formula (eHF) in infants suffering from GER. Ten infants showing GER symptoms and 10 normal babies, all fed with breast-milk substitutes, were enrolled. Clinical symptom scores related to GER were assessed for one week. The Gastric Emptying Time (GET) was determined by means of dynamic echography after feeding with cow's milk-derived formulae and again after a week feeding with eHF in subjects previously showing GER symptoms.

RESULTS

All infants with a clinical diagnosis for GER showed an abnormally high average GET in comparison to normal subjects (205 vs 124 min, p = 0.000). Switching to the eHF led to a significant clinical improvement (p = 0.0039) especially in babies skin-test and RAST positive to cow's milk, and to a significant decrease toward the normal value of the GET (167 min, p < 0.001).

CONCLUSIONS

The eHF tested improves GER symptoms in infants suffering from this disease. Our experience confirms and supports the use of dynamic echography as a reliable, simple, and non-invasive diagnostic method for infants with an increased GET associated with clinical symptoms of GER.

Authors+Show Affiliations

Pediatric Surgery. Medicine and Surgery Department. Siena University, Siena, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

11888491

Citation

Garzi, A, et al. "An Extensively Hydrolysed Cow's Milk Formula Improves Clinical Symptoms of Gastroesophageal Reflux and Reduces the Gastric Emptying Time in Infants." Allergologia Et Immunopathologia, vol. 30, no. 1, 2002, pp. 36-41.
Garzi A, Messina M, Frati F, et al. An extensively hydrolysed cow's milk formula improves clinical symptoms of gastroesophageal reflux and reduces the gastric emptying time in infants. Allergol Immunopathol (Madr). 2002;30(1):36-41.
Garzi, A., Messina, M., Frati, F., Carfagna, L., Zagordo, L., Belcastro, M., Parmiani, S., Sensi, L., & Marcucci, F. (2002). An extensively hydrolysed cow's milk formula improves clinical symptoms of gastroesophageal reflux and reduces the gastric emptying time in infants. Allergologia Et Immunopathologia, 30(1), 36-41.
Garzi A, et al. An Extensively Hydrolysed Cow's Milk Formula Improves Clinical Symptoms of Gastroesophageal Reflux and Reduces the Gastric Emptying Time in Infants. Allergol Immunopathol (Madr). 2002;30(1):36-41. PubMed PMID: 11888491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An extensively hydrolysed cow's milk formula improves clinical symptoms of gastroesophageal reflux and reduces the gastric emptying time in infants. AU - Garzi,A, AU - Messina,M, AU - Frati,F, AU - Carfagna,L, AU - Zagordo,L, AU - Belcastro,M, AU - Parmiani,S, AU - Sensi,L, AU - Marcucci,F, PY - 2002/3/13/pubmed PY - 2002/7/12/medline PY - 2002/3/13/entrez SP - 36 EP - 41 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 30 IS - 1 N2 - BACKGROUND: About 20 % of infants fed with breast-milk substitutes suffer from Gastro Esophageal Reflux (GER) and 1/3 of them also show Cow's Milk Allergy (CMA) symptoms. METHODS: We planned this study to assess by dynamic echography the usefulness of an Extensively Hydrolysed Cow's Milk Formula (eHF) in infants suffering from GER. Ten infants showing GER symptoms and 10 normal babies, all fed with breast-milk substitutes, were enrolled. Clinical symptom scores related to GER were assessed for one week. The Gastric Emptying Time (GET) was determined by means of dynamic echography after feeding with cow's milk-derived formulae and again after a week feeding with eHF in subjects previously showing GER symptoms. RESULTS: All infants with a clinical diagnosis for GER showed an abnormally high average GET in comparison to normal subjects (205 vs 124 min, p = 0.000). Switching to the eHF led to a significant clinical improvement (p = 0.0039) especially in babies skin-test and RAST positive to cow's milk, and to a significant decrease toward the normal value of the GET (167 min, p < 0.001). CONCLUSIONS: The eHF tested improves GER symptoms in infants suffering from this disease. Our experience confirms and supports the use of dynamic echography as a reliable, simple, and non-invasive diagnostic method for infants with an increased GET associated with clinical symptoms of GER. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/11888491/An_extensively_hydrolysed_cow's_milk_formula_improves_clinical_symptoms_of_gastroesophageal_reflux_and_reduces_the_gastric_emptying_time_in_infants_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0301-0546/30/36 DB - PRIME DP - Unbound Medicine ER -