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Diet supplementation with vitamin E, vitamin C and beta-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes.
Pflugers Arch 2002; 443(5-6):791-7PA

Abstract

Exercise increases oxygen consumption and causes a disturbance of intracellular pro-oxidant-antioxidant homeostasis. Few data are available as to the cumulative effects of exercise on the antioxidant defenses of the neutrophil. We studied the effects of 90 days' supplementation with placebo or an antioxidant cocktail of vitamin E (500 mg/day) and beta-carotene (30 mg/day) and the last 15 days also with vitamin C (1 g/day) on sportsmen's basal neutrophil antioxidant defenses. We analyzed the activities of catalase, glutathione peroxidase, glutathione reductase and the activities and levels of superoxide dismutase, glutathione and glutathione disulfide in neutrophils purified from antecubital vein blood of sportsmen before and after diet supplementation. Plasma vitamin E, beta-carotene and vitamin C concentrations in the antioxidant-supplemented group were approximately 1.6, 10, and 1.2 times higher respectively than those of the placebo group. The antioxidant-supplemented group presented a significantly higher glutathione versus glutathione disulfide ratio in neutrophils (about 20%) than the placebo one. Antioxidant supplementation enhances the antioxidant enzyme activity of superoxide dismutase and catalase in neutrophils.

Authors+Show Affiliations

Laboratori de Ciències de l'Activitat Física and Departament de Biologia Fonamental i Ciències de la Salut, Edifici Guillem Colom. Facultat de Ciències, Universitat de les Illes Balears, Campus Universitari, 07071, Palma de Mallorca, Balears, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11889577

Citation

Tauler, P, et al. "Diet Supplementation With Vitamin E, Vitamin C and Beta-carotene Cocktail Enhances Basal Neutrophil Antioxidant Enzymes in Athletes." Pflugers Archiv : European Journal of Physiology, vol. 443, no. 5-6, 2002, pp. 791-7.
Tauler P, Aguiló A, Fuentespina E, et al. Diet supplementation with vitamin E, vitamin C and beta-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes. Pflugers Arch. 2002;443(5-6):791-7.
Tauler, P., Aguiló, A., Fuentespina, E., Tur, J. A., & Pons, A. (2002). Diet supplementation with vitamin E, vitamin C and beta-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes. Pflugers Archiv : European Journal of Physiology, 443(5-6), pp. 791-7.
Tauler P, et al. Diet Supplementation With Vitamin E, Vitamin C and Beta-carotene Cocktail Enhances Basal Neutrophil Antioxidant Enzymes in Athletes. Pflugers Arch. 2002;443(5-6):791-7. PubMed PMID: 11889577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet supplementation with vitamin E, vitamin C and beta-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes. AU - Tauler,P, AU - Aguiló,A, AU - Fuentespina,E, AU - Tur,J A, AU - Pons,A, Y1 - 2002/01/31/ PY - 2001/06/14/received PY - 2001/10/10/accepted PY - 2002/3/13/pubmed PY - 2002/7/26/medline PY - 2002/3/13/entrez SP - 791 EP - 7 JF - Pflugers Archiv : European journal of physiology JO - Pflugers Arch. VL - 443 IS - 5-6 N2 - Exercise increases oxygen consumption and causes a disturbance of intracellular pro-oxidant-antioxidant homeostasis. Few data are available as to the cumulative effects of exercise on the antioxidant defenses of the neutrophil. We studied the effects of 90 days' supplementation with placebo or an antioxidant cocktail of vitamin E (500 mg/day) and beta-carotene (30 mg/day) and the last 15 days also with vitamin C (1 g/day) on sportsmen's basal neutrophil antioxidant defenses. We analyzed the activities of catalase, glutathione peroxidase, glutathione reductase and the activities and levels of superoxide dismutase, glutathione and glutathione disulfide in neutrophils purified from antecubital vein blood of sportsmen before and after diet supplementation. Plasma vitamin E, beta-carotene and vitamin C concentrations in the antioxidant-supplemented group were approximately 1.6, 10, and 1.2 times higher respectively than those of the placebo group. The antioxidant-supplemented group presented a significantly higher glutathione versus glutathione disulfide ratio in neutrophils (about 20%) than the placebo one. Antioxidant supplementation enhances the antioxidant enzyme activity of superoxide dismutase and catalase in neutrophils. SN - 0031-6768 UR - https://www.unboundmedicine.com/medline/citation/11889577/Diet_supplementation_with_vitamin_E_vitamin_C_and_beta_carotene_cocktail_enhances_basal_neutrophil_antioxidant_enzymes_in_athletes_ L2 - https://dx.doi.org/10.1007/s00424-001-0770-0 DB - PRIME DP - Unbound Medicine ER -