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Different expression of endothelin in the bronchoalveolar lavage in patients with pulmonary diseases.
Lung. 2001; 179(3):163-74.LUNG

Abstract

Endothelin (ET) is a broncho- and vasoconstrictive cytokine, but it also possesses proinflammatory and mitogenic activity. It is suggested to be involved in the pathogenesis of fibrotic lung diseases. We analyzed the concentration of ET 1 in the bronchoalveolar lavage (BAL) fluid in 95 patients with different lung diseases, among them 41 patients with interstitial lung diseases (13 fibrosing alveolitis in systemic sclerosis (FASS), 9 idiopathic pulmonary fibrosis (IFP), 8 sarcoidosis (S), 6 occupational lung disease (OLD), 5 other alveolitidies A), 27 patients with pneumonia, and 8 patients with chronic obstructive pulmonary disease (COPD). A heterogeneous group of 19 patients served as controls. The median ET concentration was 3.3 pg/ml. Significantly higher concentration was found in patients with FASS (5.8 pg/ml), IPF (5.0 pg/ml), and S (5.1 pg/ml) compared with OLD (2.8 pg/ml), A (1.9 pg/ml), COPD (1.5 pg/ml), and the control group (2.5 pg/ml). In pneumonia, the elevated ET concentration (4.1 pg/ml) was accompanied by a high alveolocapillary leakage. When normalized to BAL albumin concentration, only FASS presented with significantly elevated ET/albumin in the BAL compared with the control group (134.5 vs. 56.l pg/mg, p < 0.05). There were no correlations between ET and BAL differential cell count or pulmonary function tests. In current smokers, ET in BALF was significantly higher compared with non- or ex-smokers (3.9 vs. 2.0 pg/ml, p < 0.01), but not so the ET/albumin ratio (65.0 vs. 62.5 pg/mg). In summary, ET in the BAL is differentially expressed in distinct inflammatory and interstitial lung disease. Consistently high concentrations are found in FASS and elevated ET concentration could be discussed in IPF, sarcoidosis, and pneumonia. ET concentration in BAL is influenced by current smoking habits.

Authors+Show Affiliations

Division of Pneumology, Department of Internal Medicine, University Hospital, Johannisalle 32, 04105 Leipzig, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11891606

Citation

Reichenberger, F, et al. "Different Expression of Endothelin in the Bronchoalveolar Lavage in Patients With Pulmonary Diseases." Lung, vol. 179, no. 3, 2001, pp. 163-74.
Reichenberger F, Schauer J, Kellner K, et al. Different expression of endothelin in the bronchoalveolar lavage in patients with pulmonary diseases. Lung. 2001;179(3):163-74.
Reichenberger, F., Schauer, J., Kellner, K., Sack, U., Stiehl, P., & Winkler, J. (2001). Different expression of endothelin in the bronchoalveolar lavage in patients with pulmonary diseases. Lung, 179(3), 163-74.
Reichenberger F, et al. Different Expression of Endothelin in the Bronchoalveolar Lavage in Patients With Pulmonary Diseases. Lung. 2001;179(3):163-74. PubMed PMID: 11891606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different expression of endothelin in the bronchoalveolar lavage in patients with pulmonary diseases. AU - Reichenberger,F, AU - Schauer,J, AU - Kellner,K, AU - Sack,U, AU - Stiehl,P, AU - Winkler,J, Y1 - 2002/02/04/ PY - 2001/08/13/accepted PY - 2002/3/14/pubmed PY - 2002/4/11/medline PY - 2002/3/14/entrez SP - 163 EP - 74 JF - Lung JO - Lung VL - 179 IS - 3 N2 - Endothelin (ET) is a broncho- and vasoconstrictive cytokine, but it also possesses proinflammatory and mitogenic activity. It is suggested to be involved in the pathogenesis of fibrotic lung diseases. We analyzed the concentration of ET 1 in the bronchoalveolar lavage (BAL) fluid in 95 patients with different lung diseases, among them 41 patients with interstitial lung diseases (13 fibrosing alveolitis in systemic sclerosis (FASS), 9 idiopathic pulmonary fibrosis (IFP), 8 sarcoidosis (S), 6 occupational lung disease (OLD), 5 other alveolitidies A), 27 patients with pneumonia, and 8 patients with chronic obstructive pulmonary disease (COPD). A heterogeneous group of 19 patients served as controls. The median ET concentration was 3.3 pg/ml. Significantly higher concentration was found in patients with FASS (5.8 pg/ml), IPF (5.0 pg/ml), and S (5.1 pg/ml) compared with OLD (2.8 pg/ml), A (1.9 pg/ml), COPD (1.5 pg/ml), and the control group (2.5 pg/ml). In pneumonia, the elevated ET concentration (4.1 pg/ml) was accompanied by a high alveolocapillary leakage. When normalized to BAL albumin concentration, only FASS presented with significantly elevated ET/albumin in the BAL compared with the control group (134.5 vs. 56.l pg/mg, p < 0.05). There were no correlations between ET and BAL differential cell count or pulmonary function tests. In current smokers, ET in BALF was significantly higher compared with non- or ex-smokers (3.9 vs. 2.0 pg/ml, p < 0.01), but not so the ET/albumin ratio (65.0 vs. 62.5 pg/mg). In summary, ET in the BAL is differentially expressed in distinct inflammatory and interstitial lung disease. Consistently high concentrations are found in FASS and elevated ET concentration could be discussed in IPF, sarcoidosis, and pneumonia. ET concentration in BAL is influenced by current smoking habits. SN - 0341-2040 UR - https://www.unboundmedicine.com/medline/citation/11891606/Different_expression_of_endothelin_in_the_bronchoalveolar_lavage_in_patients_with_pulmonary_diseases_ L2 - https://dx.doi.org/10.1007/s004080000058 DB - PRIME DP - Unbound Medicine ER -