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Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men.
Int J Obes Relat Metab Disord. 2002 Mar; 26(3):361-9.IJ

Abstract

OBJECTIVE

To investigate whether the changes in IGF-I concentrations after weight reduction in Japanese overweight men are associated with changes in visceral and subcutaneous fat.

DESIGN

Cross-sectional and longitudinal clinical intervention study with exercise education.

SUBJECTS

One-hundred and twelve Japanese overweight men aged 30-59 y (body mass index (BMI) 28.4+/-2.5 kg/m(2)) and 33 normal-weight men aged 30-39 y (BMI 22.1+/-1.5 kg/m(2)) at baseline. From the participants, 56 randomly selected overweight men (BMI 28.8+/-2.8) were further enrolled into a 1 y exercise program.

MEASUREMENTS

Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, metabolic parameters and hormones including insulin, leptin and IGF-I at baseline and after 1 y.

RESULTS

In 112 overweight subjects at baseline, insulin (10.5+/-5.0 microU/ml) and leptin (6.4+/-3.7 ng/ml) significantly correlated with both V (r=0.260, P=0.0073; r=0.410, P<0.0001) and S areas (r=0.377, P<0.0001; r=0.613, P<0.0001), respectively. IGF-I (156.8+/-48.7 microU/ml) significantly and negatively correlated with V area (r=-0.242, P=0.0125) and age (r=-0.192, P=0.0480). In normal-weight men aged 30-39 y (n=33) and age-matched subjects (n=30) selected from the 112 overweight men, the serum IGF-I further tightly correlated with V area (r=-0.467, P<0.0001). Visceral fat area and age were independently related to serum IGF-I levels by multiple regression analysis. By intervention with exercise education, 56 overweight subjects showed an increase in daily steps (6224+/-2781 to 7898+/-4141 steps/day) and reduction of BMI (28.8+/-2.8 to 27.7+/-2.9). deltaIGF-I significantly correlated with deltaV area (r=-0.432, P=0.0009) but not with DeltaS area or deltaBMI.

CONCLUSION

The present study indicated a negative correlation between IGF-I levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-I levels after an exercise intervention.

Authors+Show Affiliations

Department of Medicine III, Okayama University Medical School, Okayama, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11896491

Citation

Kunitomi, M, et al. "Relationship Between Reduced Serum IGF-I Levels and Accumulation of Visceral Fat in Japanese Men." International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, vol. 26, no. 3, 2002, pp. 361-9.
Kunitomi M, Wada J, Takahashi K, et al. Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men. Int J Obes Relat Metab Disord. 2002;26(3):361-9.
Kunitomi, M., Wada, J., Takahashi, K., Tsuchiyama, Y., Mimura, Y., Hida, K., Miyatake, N., Fujii, M., Kira, S., Shikata, K., & Maknio, H. (2002). Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 26(3), 361-9.
Kunitomi M, et al. Relationship Between Reduced Serum IGF-I Levels and Accumulation of Visceral Fat in Japanese Men. Int J Obes Relat Metab Disord. 2002;26(3):361-9. PubMed PMID: 11896491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men. AU - Kunitomi,M, AU - Wada,J, AU - Takahashi,K, AU - Tsuchiyama,Y, AU - Mimura,Y, AU - Hida,K, AU - Miyatake,N, AU - Fujii,M, AU - Kira,S, AU - Shikata,K, AU - Maknio,H, PY - 2001/02/15/received PY - 2001/09/06/revised PY - 2001/10/10/accepted PY - 2002/3/16/pubmed PY - 2002/4/18/medline PY - 2002/3/16/entrez SP - 361 EP - 9 JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity JO - Int J Obes Relat Metab Disord VL - 26 IS - 3 N2 - OBJECTIVE: To investigate whether the changes in IGF-I concentrations after weight reduction in Japanese overweight men are associated with changes in visceral and subcutaneous fat. DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education. SUBJECTS: One-hundred and twelve Japanese overweight men aged 30-59 y (body mass index (BMI) 28.4+/-2.5 kg/m(2)) and 33 normal-weight men aged 30-39 y (BMI 22.1+/-1.5 kg/m(2)) at baseline. From the participants, 56 randomly selected overweight men (BMI 28.8+/-2.8) were further enrolled into a 1 y exercise program. MEASUREMENTS: Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, metabolic parameters and hormones including insulin, leptin and IGF-I at baseline and after 1 y. RESULTS: In 112 overweight subjects at baseline, insulin (10.5+/-5.0 microU/ml) and leptin (6.4+/-3.7 ng/ml) significantly correlated with both V (r=0.260, P=0.0073; r=0.410, P<0.0001) and S areas (r=0.377, P<0.0001; r=0.613, P<0.0001), respectively. IGF-I (156.8+/-48.7 microU/ml) significantly and negatively correlated with V area (r=-0.242, P=0.0125) and age (r=-0.192, P=0.0480). In normal-weight men aged 30-39 y (n=33) and age-matched subjects (n=30) selected from the 112 overweight men, the serum IGF-I further tightly correlated with V area (r=-0.467, P<0.0001). Visceral fat area and age were independently related to serum IGF-I levels by multiple regression analysis. By intervention with exercise education, 56 overweight subjects showed an increase in daily steps (6224+/-2781 to 7898+/-4141 steps/day) and reduction of BMI (28.8+/-2.8 to 27.7+/-2.9). deltaIGF-I significantly correlated with deltaV area (r=-0.432, P=0.0009) but not with DeltaS area or deltaBMI. CONCLUSION: The present study indicated a negative correlation between IGF-I levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-I levels after an exercise intervention. UR - https://www.unboundmedicine.com/medline/citation/11896491/Relationship_between_reduced_serum_IGF_I_levels_and_accumulation_of_visceral_fat_in_Japanese_men_ L2 - https://medlineplus.gov/weightcontrol.html DB - PRIME DP - Unbound Medicine ER -