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Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies.
J Neurol Sci. 2002 Mar 30; 195(2):153-9.JN

Abstract

Using alpha-synuclein-immunohistochemistry, 27 brains of dementia with Lewy bodies (DLB) were investigated to identify the progression of Lewy pathology including Lewy bodies (LB) and LB-related neurites in the cerebrum. The numbers of alpha-synuclein-positive LB and LB-related neurites were semiquantitatively evaluated in the amygdala, hippocampus, entorhinal cortex, transentorhinal cortex, insular cortex, middle temporal cortex and superior frontal cortex. The results indicated that Lewy pathology within the neuron progresses first in the axonal terminal, subsequently in the cell body and finally in the dendrite, that Lewy pathology in the cerebral cortex progresses first in layers V-VI, subsequently in layer III and finally in layer II, and that Lewy pathology in the cerebrum progresses first in the amygdala, subsequently in the limbic cortex and finally in the neocortex. In addition, Lewy pathology was graded from stage I to stage IV based on the progression of Lewy pathology. The 27 brains examined were classified into 3 brains showing stage I, 11 showing stage II, 7 showing stage III and 6 showing stage IV. Comparing these stages with the pathological subtypes of DLB brains, brains of the subtype showing severe Alzheimer pathology corresponded to brains showing an advanced stage, suggesting that Alzheimer pathology exacerbates Lewy pathology.

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Authors+Show Affiliations

Marui W
Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Yokohama 236-0004, Kanazawa, Japan.
Iseki E
No affiliation info available
Nakai T
No affiliation info available
Miura S
No affiliation info available
Kato M
No affiliation info available
Uéda K
No affiliation info available
Kosaka K
No affiliation info available

MeSH

AgedAntibody SpecificityBrainDisease ProgressionHumansImmunohistochemistryLewy BodiesLewy Body DiseaseMicroscopy, ElectronNerve Tissue ProteinsNeuritesNeuronsSynucleinsalpha-Synuclein

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11897247

Citation

Marui, Wami, et al. "Progression and Staging of Lewy Pathology in Brains From Patients With Dementia With Lewy Bodies." Journal of the Neurological Sciences, vol. 195, no. 2, 2002, pp. 153-9.
Marui W, Iseki E, Nakai T, et al. Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies. J Neurol Sci. 2002;195(2):153-9.
Marui, W., Iseki, E., Nakai, T., Miura, S., Kato, M., Uéda, K., & Kosaka, K. (2002). Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies. Journal of the Neurological Sciences, 195(2), 153-9.
Marui W, et al. Progression and Staging of Lewy Pathology in Brains From Patients With Dementia With Lewy Bodies. J Neurol Sci. 2002 Mar 30;195(2):153-9. PubMed PMID: 11897247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies. AU - Marui,Wami, AU - Iseki,Eizo, AU - Nakai,Toshiki, AU - Miura,Satoshi, AU - Kato,Masanori, AU - Uéda,Kenji, AU - Kosaka,Kenji, PY - 2002/3/19/pubmed PY - 2002/5/31/medline PY - 2002/3/19/entrez SP - 153 EP - 9 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 195 IS - 2 N2 - Using alpha-synuclein-immunohistochemistry, 27 brains of dementia with Lewy bodies (DLB) were investigated to identify the progression of Lewy pathology including Lewy bodies (LB) and LB-related neurites in the cerebrum. The numbers of alpha-synuclein-positive LB and LB-related neurites were semiquantitatively evaluated in the amygdala, hippocampus, entorhinal cortex, transentorhinal cortex, insular cortex, middle temporal cortex and superior frontal cortex. The results indicated that Lewy pathology within the neuron progresses first in the axonal terminal, subsequently in the cell body and finally in the dendrite, that Lewy pathology in the cerebral cortex progresses first in layers V-VI, subsequently in layer III and finally in layer II, and that Lewy pathology in the cerebrum progresses first in the amygdala, subsequently in the limbic cortex and finally in the neocortex. In addition, Lewy pathology was graded from stage I to stage IV based on the progression of Lewy pathology. The 27 brains examined were classified into 3 brains showing stage I, 11 showing stage II, 7 showing stage III and 6 showing stage IV. Comparing these stages with the pathological subtypes of DLB brains, brains of the subtype showing severe Alzheimer pathology corresponded to brains showing an advanced stage, suggesting that Alzheimer pathology exacerbates Lewy pathology. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/11897247/Progression_and_staging_of_Lewy_pathology_in_brains_from_patients_with_dementia_with_Lewy_bodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022510X02000060 DB - PRIME DP - Unbound Medicine ER -