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Effect of 1-(3,4-methylenedioxyphenyl)-2-aminopropane and its optical isomers in PMMA-trained rats.
Pharmacol Biochem Behav. 2002 May; 72(1-2):307-11.PB

Abstract

1-(3,4-Methylenedioxyphenyl)-2-aminopropane (MDA) is a drug of abuse that is known to produce stimulus effects similar to those of the stimulant phenylalkylamine (+)amphetamine and the hallucinogenic phenylalkylamine 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM). Earlier, a working model was described to account for the stimulus effects produced by phenylalkylamines. Such agents can produce one or more of three distinct effects: an amphetamine effect, a DOM effect and a third effect that is typified by the agent N-methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA). Because MDA is known to produce two of the three effects, in the present investigation, we sought to determine if racemic MDA or either of its optical isomers could produce a PMMA-like effect in animals. Administration of S(+)MDA, R(-)MDA and (+/-)MDA to rats trained to discriminate 1.25 mg/kg of PMMA from saline vehicle under a VI 15-s schedule of reinforcement resulted in substitution in each case. (+/-)MDA and S(+)MDA were nearly equipotent and several fold more potent than R(-)MDA. The results are not only consistent with the proposed model but also identify (+/-)MDA as the first phenylalkylamine shown to produce all three types of stimulus effects (i.e., amphetamine-like, DOM-like and PMMA-like) in rats.

Authors+Show Affiliations

Department of Medicinal Chemistry, School of Pharmacy, Box 980540, Virginia Commonwealth University, Richmond, VA 23298-0540, USA. glennon@hsc.vcu.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11900801

Citation

Glennon, Richard A., and Richard Young. "Effect of 1-(3,4-methylenedioxyphenyl)-2-aminopropane and Its Optical Isomers in PMMA-trained Rats." Pharmacology, Biochemistry, and Behavior, vol. 72, no. 1-2, 2002, pp. 307-11.
Glennon RA, Young R. Effect of 1-(3,4-methylenedioxyphenyl)-2-aminopropane and its optical isomers in PMMA-trained rats. Pharmacol Biochem Behav. 2002;72(1-2):307-11.
Glennon, R. A., & Young, R. (2002). Effect of 1-(3,4-methylenedioxyphenyl)-2-aminopropane and its optical isomers in PMMA-trained rats. Pharmacology, Biochemistry, and Behavior, 72(1-2), 307-11.
Glennon RA, Young R. Effect of 1-(3,4-methylenedioxyphenyl)-2-aminopropane and Its Optical Isomers in PMMA-trained Rats. Pharmacol Biochem Behav. 2002;72(1-2):307-11. PubMed PMID: 11900801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of 1-(3,4-methylenedioxyphenyl)-2-aminopropane and its optical isomers in PMMA-trained rats. AU - Glennon,Richard A, AU - Young,Richard, PY - 2002/3/20/pubmed PY - 2003/10/22/medline PY - 2002/3/20/entrez SP - 307 EP - 11 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 72 IS - 1-2 N2 - 1-(3,4-Methylenedioxyphenyl)-2-aminopropane (MDA) is a drug of abuse that is known to produce stimulus effects similar to those of the stimulant phenylalkylamine (+)amphetamine and the hallucinogenic phenylalkylamine 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM). Earlier, a working model was described to account for the stimulus effects produced by phenylalkylamines. Such agents can produce one or more of three distinct effects: an amphetamine effect, a DOM effect and a third effect that is typified by the agent N-methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA). Because MDA is known to produce two of the three effects, in the present investigation, we sought to determine if racemic MDA or either of its optical isomers could produce a PMMA-like effect in animals. Administration of S(+)MDA, R(-)MDA and (+/-)MDA to rats trained to discriminate 1.25 mg/kg of PMMA from saline vehicle under a VI 15-s schedule of reinforcement resulted in substitution in each case. (+/-)MDA and S(+)MDA were nearly equipotent and several fold more potent than R(-)MDA. The results are not only consistent with the proposed model but also identify (+/-)MDA as the first phenylalkylamine shown to produce all three types of stimulus effects (i.e., amphetamine-like, DOM-like and PMMA-like) in rats. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/11900801/Effect_of_1__34_methylenedioxyphenyl__2_aminopropane_and_its_optical_isomers_in_PMMA_trained_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091305701007705 DB - PRIME DP - Unbound Medicine ER -