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Selective responses of three Ginkgo biloba leaf-derived constituents on human intestinal bacteria.
J Agric Food Chem. 2002 Mar 27; 50(7):1840-4.JA

Abstract

The selective responses of Ginkgo biloba leaf-derived materials against six intestinal bacteria was examined using an impregnated paper disk method and compared with that of bilobalide, ginkgolides A and B, kaempferol, and quercetin. The components of G. biloba leaves were characterized as kaempferol 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside), kaempferol 3-O-(2' '-O-beta-D-glucopyranosyl)-alpha-L-rhamnopyranoside, and quercetin 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) by spectroscopic analysis. The growth responses varied with each bacterial strain tested. At 2 mg/disk, kaempferol 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) and quercetin 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) revealed potent inhibition against Clostridium perfringens, and kaempferol 3-O-(2' '-O-beta-D-glucopyranosyl)-alpha-L-rhamnopyranoside showed a clear inhibitory effect on Escherichia coli. At 0.5 mg/disk, quercetin 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) showed a strong activity against C. perfringens, but weak activity was exhibited by kaempferol 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) against C. perfringens and kaempferol 3-O-(2' '-O-beta-D-glucopyranosyl)-alpha-L-rhamnopyranoside against E. coli. No inhibition was observed from treatments conducted with bilobalide, ginkgolides A and B, kaempferol, or quercetin. Furthermore, these isolated compounds did not inhibit Bifidobacterium bifidum, B. longum, B. adolescentis, or Lactobacillus acidophilus.

Authors+Show Affiliations

Research Center for Industrial Development of Biofood Materials and Institute of Agricultural Science & Technology, College of Agriculture, Chonbuk National University, Chonju 561-756, Korea. hoiseon@moak.chonbuk.ac.krNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11902921

Citation

Lee, Hoi-Seon, and Min-Jeong Kim. "Selective Responses of Three Ginkgo Biloba Leaf-derived Constituents On Human Intestinal Bacteria." Journal of Agricultural and Food Chemistry, vol. 50, no. 7, 2002, pp. 1840-4.
Lee HS, Kim MJ. Selective responses of three Ginkgo biloba leaf-derived constituents on human intestinal bacteria. J Agric Food Chem. 2002;50(7):1840-4.
Lee, H. S., & Kim, M. J. (2002). Selective responses of three Ginkgo biloba leaf-derived constituents on human intestinal bacteria. Journal of Agricultural and Food Chemistry, 50(7), 1840-4.
Lee HS, Kim MJ. Selective Responses of Three Ginkgo Biloba Leaf-derived Constituents On Human Intestinal Bacteria. J Agric Food Chem. 2002 Mar 27;50(7):1840-4. PubMed PMID: 11902921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective responses of three Ginkgo biloba leaf-derived constituents on human intestinal bacteria. AU - Lee,Hoi-Seon, AU - Kim,Min-Jeong, PY - 2002/3/21/pubmed PY - 2002/5/23/medline PY - 2002/3/21/entrez SP - 1840 EP - 4 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 50 IS - 7 N2 - The selective responses of Ginkgo biloba leaf-derived materials against six intestinal bacteria was examined using an impregnated paper disk method and compared with that of bilobalide, ginkgolides A and B, kaempferol, and quercetin. The components of G. biloba leaves were characterized as kaempferol 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside), kaempferol 3-O-(2' '-O-beta-D-glucopyranosyl)-alpha-L-rhamnopyranoside, and quercetin 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) by spectroscopic analysis. The growth responses varied with each bacterial strain tested. At 2 mg/disk, kaempferol 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) and quercetin 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) revealed potent inhibition against Clostridium perfringens, and kaempferol 3-O-(2' '-O-beta-D-glucopyranosyl)-alpha-L-rhamnopyranoside showed a clear inhibitory effect on Escherichia coli. At 0.5 mg/disk, quercetin 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) showed a strong activity against C. perfringens, but weak activity was exhibited by kaempferol 3-O-alpha-(6' "-p-coumaroylglucosyl-beta-1,4-rhamnoside) against C. perfringens and kaempferol 3-O-(2' '-O-beta-D-glucopyranosyl)-alpha-L-rhamnopyranoside against E. coli. No inhibition was observed from treatments conducted with bilobalide, ginkgolides A and B, kaempferol, or quercetin. Furthermore, these isolated compounds did not inhibit Bifidobacterium bifidum, B. longum, B. adolescentis, or Lactobacillus acidophilus. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/11902921/Selective_responses_of_three_Ginkgo_biloba_leaf_derived_constituents_on_human_intestinal_bacteria_ L2 - https://doi.org/10.1021/jf011140a DB - PRIME DP - Unbound Medicine ER -