Tags

Type your tag names separated by a space and hit enter

Free radical studies of ellagic acid, a natural phenolic antioxidant.
J Agric Food Chem. 2002 Mar 27; 50(7):2200-6.JA

Abstract

Ellagic acid, a plant-derived polyphenol, inhibits gamma-radiation (hydroxyl radical) induced lipid peroxidation in rat liver microsomes in a dose- and concentration-dependent manner. Its antioxidant capacity has been estimated using the 1,1-diphenyl-2-picrylhydrazyl radical assay. To understand the actual mechanisms involved in antioxidant activity and the free radical scavenging ability,a nanosecond pulse radiolysis technique has been employed. The rate constants for the reactions of several reactive oxygen species and reactive nitrogen species such as hydroxyl, peroxyl, and nitrogen dioxide radicals have been found to be in the range of 10(6)-10(9) M(-1) s(-1). The ellagic acid radicals have been characterized by the absorption spectra and decay kinetics. Studies on the reactions of ellagic acid with the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) radical and the radicals of ellagic acid with ascorbate have been used to estimate its one-electron reduction potential. Ellagic acid has also been found to be a good scavenger of peroxynitrite. Using stopped-flow reaction analyzer with absorption detection, the rate constant for this reaction has been determined to be 3.7 x 10(3) M(-1) s (-1). The electron spin resonance spectra of the oxidized ellagic acid radicals have been recorded by horseradish peroxidase and hydrogen peroxide method.

Authors+Show Affiliations

Radiation Chemistry and Chemical Dynamics Division and Cell Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India. kindira@apsara.barc.ernet.inNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11902978

Citation

Priyadarsini, K Indira, et al. "Free Radical Studies of Ellagic Acid, a Natural Phenolic Antioxidant." Journal of Agricultural and Food Chemistry, vol. 50, no. 7, 2002, pp. 2200-6.
Priyadarsini KI, Khopde SM, Kumar SS, et al. Free radical studies of ellagic acid, a natural phenolic antioxidant. J Agric Food Chem. 2002;50(7):2200-6.
Priyadarsini, K. I., Khopde, S. M., Kumar, S. S., & Mohan, H. (2002). Free radical studies of ellagic acid, a natural phenolic antioxidant. Journal of Agricultural and Food Chemistry, 50(7), 2200-6.
Priyadarsini KI, et al. Free Radical Studies of Ellagic Acid, a Natural Phenolic Antioxidant. J Agric Food Chem. 2002 Mar 27;50(7):2200-6. PubMed PMID: 11902978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free radical studies of ellagic acid, a natural phenolic antioxidant. AU - Priyadarsini,K Indira, AU - Khopde,Sujata M, AU - Kumar,S Santosh, AU - Mohan,Hari, PY - 2002/3/21/pubmed PY - 2002/5/23/medline PY - 2002/3/21/entrez SP - 2200 EP - 6 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 50 IS - 7 N2 - Ellagic acid, a plant-derived polyphenol, inhibits gamma-radiation (hydroxyl radical) induced lipid peroxidation in rat liver microsomes in a dose- and concentration-dependent manner. Its antioxidant capacity has been estimated using the 1,1-diphenyl-2-picrylhydrazyl radical assay. To understand the actual mechanisms involved in antioxidant activity and the free radical scavenging ability,a nanosecond pulse radiolysis technique has been employed. The rate constants for the reactions of several reactive oxygen species and reactive nitrogen species such as hydroxyl, peroxyl, and nitrogen dioxide radicals have been found to be in the range of 10(6)-10(9) M(-1) s(-1). The ellagic acid radicals have been characterized by the absorption spectra and decay kinetics. Studies on the reactions of ellagic acid with the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) radical and the radicals of ellagic acid with ascorbate have been used to estimate its one-electron reduction potential. Ellagic acid has also been found to be a good scavenger of peroxynitrite. Using stopped-flow reaction analyzer with absorption detection, the rate constant for this reaction has been determined to be 3.7 x 10(3) M(-1) s (-1). The electron spin resonance spectra of the oxidized ellagic acid radicals have been recorded by horseradish peroxidase and hydrogen peroxide method. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/11902978/Free_radical_studies_of_ellagic_acid_a_natural_phenolic_antioxidant_ L2 - https://doi.org/10.1021/jf011275g DB - PRIME DP - Unbound Medicine ER -