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Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies.
Acta Anaesthesiol Scand. 2002 Jan; 46(1):109-13.AA

Abstract

BACKGROUND

Ondansetron has a well documented antiemetic prophylactic effect, whereas in most studies of postoperative nausea and vomiting (PONV), metoclopramide is less efficacious. This can be attributed to the short-lasting effect of metoclopramide when a low dose is given at the beginning of surgery. We wanted to test a 20-mg dose of metoclopramide given at the end of surgery, using ondansetron 8 mg as a reference.

METHODS

122 patients scheduled for elective laparoscopic cholecystectomy under general anesthesia were studied in a randomized, double-blind study design. At the end of the procedure, the patients received either metoclopramide 20 mg or ondansetron 8 mg intravenously. The patients were observed for 24 h for PONV, pain, side-effects and need for rescue antiemetic medication.

RESULTS

No significant differences in the incidence of PONV or need for rescue antiemetic treatment was observed in the 0-24 h postoperative study period. The overall incidence of PONV was 43% in the ondansetron group and 47% in the metoclopramide group. The ondansetron patients had a significantly higher incidence of moderate or strong pain during the postoperative observation period (61% vs. 35% in the metoclopramide group) (P < 0.05). No significant differences in side-effects between the groups were observed.

CONCLUSIONS

Metoclopramide 20 mg i.v. given at the end of laparoscopic cholecystectomy resulted in a similar incidence of PONV compared with ondansetron 8 mg. The patients receiving metoclopramide had less pain than the patients receiving ondansetron.

Authors+Show Affiliations

Department of Anesthesia, Kongsberg Hospital, Ullevaal University Hospital, Oslo, Norway. hen-qua@frisurf.noNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11903083

Citation

Quaynor, H, and J C. Raeder. "Incidence and Severity of Postoperative Nausea and Vomiting Are Similar After Metoclopramide 20 Mg and Ondansetron 8 Mg Given By the End of Laparoscopic Cholecystectomies." Acta Anaesthesiologica Scandinavica, vol. 46, no. 1, 2002, pp. 109-13.
Quaynor H, Raeder JC. Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. Acta Anaesthesiol Scand. 2002;46(1):109-13.
Quaynor, H., & Raeder, J. C. (2002). Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. Acta Anaesthesiologica Scandinavica, 46(1), 109-13.
Quaynor H, Raeder JC. Incidence and Severity of Postoperative Nausea and Vomiting Are Similar After Metoclopramide 20 Mg and Ondansetron 8 Mg Given By the End of Laparoscopic Cholecystectomies. Acta Anaesthesiol Scand. 2002;46(1):109-13. PubMed PMID: 11903083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. AU - Quaynor,H, AU - Raeder,J C, PY - 2002/3/21/pubmed PY - 2002/5/9/medline PY - 2002/3/21/entrez SP - 109 EP - 13 JF - Acta anaesthesiologica Scandinavica JO - Acta Anaesthesiol Scand VL - 46 IS - 1 N2 - BACKGROUND: Ondansetron has a well documented antiemetic prophylactic effect, whereas in most studies of postoperative nausea and vomiting (PONV), metoclopramide is less efficacious. This can be attributed to the short-lasting effect of metoclopramide when a low dose is given at the beginning of surgery. We wanted to test a 20-mg dose of metoclopramide given at the end of surgery, using ondansetron 8 mg as a reference. METHODS: 122 patients scheduled for elective laparoscopic cholecystectomy under general anesthesia were studied in a randomized, double-blind study design. At the end of the procedure, the patients received either metoclopramide 20 mg or ondansetron 8 mg intravenously. The patients were observed for 24 h for PONV, pain, side-effects and need for rescue antiemetic medication. RESULTS: No significant differences in the incidence of PONV or need for rescue antiemetic treatment was observed in the 0-24 h postoperative study period. The overall incidence of PONV was 43% in the ondansetron group and 47% in the metoclopramide group. The ondansetron patients had a significantly higher incidence of moderate or strong pain during the postoperative observation period (61% vs. 35% in the metoclopramide group) (P < 0.05). No significant differences in side-effects between the groups were observed. CONCLUSIONS: Metoclopramide 20 mg i.v. given at the end of laparoscopic cholecystectomy resulted in a similar incidence of PONV compared with ondansetron 8 mg. The patients receiving metoclopramide had less pain than the patients receiving ondansetron. SN - 0001-5172 UR - https://www.unboundmedicine.com/medline/citation/11903083/Incidence_and_severity_of_postoperative_nausea_and_vomiting_are_similar_after_metoclopramide_20_mg_and_ondansetron_8_mg_given_by_the_end_of_laparoscopic_cholecystectomies_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0001-5172&amp;date=2002&amp;volume=46&amp;issue=1&amp;spage=109 DB - PRIME DP - Unbound Medicine ER -