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Biological risk factors for deep vein trombosis.

Abstract

Hypercoagulable states due either to inherited or acquired thrombotic risk factors are only present in approximately half of cases of DVT, but the causes in the other half, remain unknown. The importance of biological risk factors such as hyperlipidemia, hypofibrinolysis and hemorheological alterations in the pathogenesis of DVT has not been well established. In order to ascertain whether the above mentioned biological factors are associated with DVT and could constitute independent risk factors, we carried out a case-control study in 109 first DVT patients in whom inherited or acquired thrombophilic risk factors had been ruled out and 121 healthy controls age (42+/-15 years) and sex matched. From all the biological variables analyzed (cholesterol, triglycerides, glucose, fibrinogen, erythrocyte aggregation, hematocrit, plasma viscosity and PAI-1) only fibrinogen concentration reached a statistically significant difference on the comparison of means (290+/-73 mg/dl in cases vs 268+/-58 mg/dl in controls, p<0.05). After this continuous variables were dichotomized according to our reference values, the percentage of cases with cholesterolemia >220 mg/dl, hematocrit >45% and fibrinogen >300 mg/dl was higher in cases than in controls: 38% vs 22%; p<0.01; 43% vs 27%; p<0.05; 36% vs 23%; p<0.05, respectively. The percentage of cases with PAI-1 values >30 ng/ml, 37% vs 25% was borderline significant; p=0.055. Multivariate logistic regression analysis showed that cholesterolemia >220 mg/dl and fibrinogen >300 mg/dl constitute independent predictors of venous thrombotic risk. The adjusted OR's were 2.03 (95% CI; 1.12-3.70) for cholesterolemia and 1.94 (95% CI; 1.07-3.55) for fibrinogen. When these two variables combined DVT risk rose about fourfold (3.96; p<0.05). Our results suggest that hypercholesterolemia and hyperfibrinogenemia should be added to the list of known DVT risk factors and we recommend adopting measures to decrease these variables in the population with a high risk of DVT.

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  • Authors+Show Affiliations

    ,

    Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain. vaya_amp@gva.es

    , , , , , ,

    Source

    MeSH

    Biomarkers
    Blood Glucose
    Blood Viscosity
    Case-Control Studies
    Cholesterol
    Erythrocyte Aggregation
    Fibrinogen
    Hematocrit
    Humans
    Plasminogen Activator Inhibitor 1
    Risk Factors
    Triglycerides
    Venous Thrombosis

    Pub Type(s)

    Congress

    Language

    eng

    PubMed ID

    11904470

    Citation

    Vayá, Amparo, et al. "Biological Risk Factors for Deep Vein Trombosis." Clinical Hemorheology and Microcirculation, vol. 26, no. 1, 2002, pp. 41-53.
    Vayá A, Mira Y, Martínez M, et al. Biological risk factors for deep vein trombosis. Clin Hemorheol Microcirc. 2002;26(1):41-53.
    Vayá, A., Mira, Y., Martínez, M., Villa, P., Ferrando, F., Estellés, A., ... Aznar, J. (2002). Biological risk factors for deep vein trombosis. Clinical Hemorheology and Microcirculation, 26(1), pp. 41-53.
    Vayá A, et al. Biological Risk Factors for Deep Vein Trombosis. Clin Hemorheol Microcirc. 2002;26(1):41-53. PubMed PMID: 11904470.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Biological risk factors for deep vein trombosis. AU - Vayá,Amparo, AU - Mira,Yolanda, AU - Martínez,Marcial, AU - Villa,Piedad, AU - Ferrando,Fernando, AU - Estellés,Amparo, AU - Corella,Dolores, AU - Aznar,Justo, PY - 2002/3/21/pubmed PY - 2002/6/21/medline PY - 2002/3/21/entrez SP - 41 EP - 53 JF - Clinical hemorheology and microcirculation JO - Clin. Hemorheol. Microcirc. VL - 26 IS - 1 N2 - Hypercoagulable states due either to inherited or acquired thrombotic risk factors are only present in approximately half of cases of DVT, but the causes in the other half, remain unknown. The importance of biological risk factors such as hyperlipidemia, hypofibrinolysis and hemorheological alterations in the pathogenesis of DVT has not been well established. In order to ascertain whether the above mentioned biological factors are associated with DVT and could constitute independent risk factors, we carried out a case-control study in 109 first DVT patients in whom inherited or acquired thrombophilic risk factors had been ruled out and 121 healthy controls age (42+/-15 years) and sex matched. From all the biological variables analyzed (cholesterol, triglycerides, glucose, fibrinogen, erythrocyte aggregation, hematocrit, plasma viscosity and PAI-1) only fibrinogen concentration reached a statistically significant difference on the comparison of means (290+/-73 mg/dl in cases vs 268+/-58 mg/dl in controls, p<0.05). After this continuous variables were dichotomized according to our reference values, the percentage of cases with cholesterolemia >220 mg/dl, hematocrit >45% and fibrinogen >300 mg/dl was higher in cases than in controls: 38% vs 22%; p<0.01; 43% vs 27%; p<0.05; 36% vs 23%; p<0.05, respectively. The percentage of cases with PAI-1 values >30 ng/ml, 37% vs 25% was borderline significant; p=0.055. Multivariate logistic regression analysis showed that cholesterolemia >220 mg/dl and fibrinogen >300 mg/dl constitute independent predictors of venous thrombotic risk. The adjusted OR's were 2.03 (95% CI; 1.12-3.70) for cholesterolemia and 1.94 (95% CI; 1.07-3.55) for fibrinogen. When these two variables combined DVT risk rose about fourfold (3.96; p<0.05). Our results suggest that hypercholesterolemia and hyperfibrinogenemia should be added to the list of known DVT risk factors and we recommend adopting measures to decrease these variables in the population with a high risk of DVT. SN - 1386-0291 UR - https://www.unboundmedicine.com/medline/citation/11904470/full_citation L2 - https://content.iospress.com/openurl?genre=article&amp;issn=1386-0291&amp;volume=26&amp;issue=1&amp;spage=41 DB - PRIME DP - Unbound Medicine ER -