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Impact of diets containing corn oil or olive/sunflower oil mixture on the human plasma and lipoprotein lipid metabolism.
Eur J Nutr 2001; 40(4):161-7EJ

Abstract

BACKGROUND

The effects of monounsaturated fatty acids (MUFA) rich diets compared to those that are rich in polyunsaturated fatty acids (PUFA) as well as the effects of an intake of single oils compared to oil mixtures are controversially discussed and results are contradictory.

AIM OF THIS STUDY

To evaluate the effects of a plant oil-mixture (olive/sunflower oil; saturated/monounsaturated/polyunsaturated (S/M/P) = 14:69:17) high in oleic acid but also showing a moderate content of polyunsaturated fatty acids (PUFA) in comparison with a single, PUFA rich corn oil (S/M/P = 13:33:54) used in a normal, balanced diet on human plasma and lipoprotein metabolism.

METHODS

The double-blind designed study comprised 28 healthy, non-smoking young men aged between 19 and 31 years. After two weeks of adjustment (mixed, balanced diet: 11.6 MJ average, average fat intake approximately 105 g/d), the design included a two week test period in which a diet with 80 g corn oil/d vs a mixture of 68 g olive- and 12 g sunflower oil/d (total 80 g) as the main fat source was given, followed by a crossover after two weeks. Compliance and ingestion of diets were monitored by assessing the fatty acid pattern in LDL and by determination of alpha- and gamma-tocopherol in plasma and LDL. Results Diets were well incorporated due to the significant changes in plasma- and LDL-tocopherol levels and the significant different average ratio of oleic acid to linoleic acid in LDL. The PUFA-rich corn oil diet was able to reduce low density lipoprotein (LDL) cholesterol from adjustment to T2 significantly (p < 0.01), which was also confirmed by a trend after cross over (p=0.15). Total cholesterol (only after cross over at T3), total triglycerides (TG) and very low density lipoprotein (VLDL)-TG were significantly lower at T2 after the corn oil diet than after the mixed oil diet. Total high density lipoproteins (HDL) and HDL cholesterol remained unchanged by both diets.

CONCLUSIONS

The results show that during the intervention of two weeks for each diet and the following cross over the corn oil diet had more influence on lipoprotein metabolism than the MUFA-rich diet. The hypocholesteremic effect of the PUFA-rich diet must also be connected with the high amount of unsaponifiable substances, mainly phytosterols in the corn oil.

Authors+Show Affiliations

Institute of Nutritional Sciences, University of Vienna, Austria. karl-heinz.wagner@univie.ac.atNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11905957

Citation

Wagner, K H., et al. "Impact of Diets Containing Corn Oil or Olive/sunflower Oil Mixture On the Human Plasma and Lipoprotein Lipid Metabolism." European Journal of Nutrition, vol. 40, no. 4, 2001, pp. 161-7.
Wagner KH, Tomasch R, Elmadfa I. Impact of diets containing corn oil or olive/sunflower oil mixture on the human plasma and lipoprotein lipid metabolism. Eur J Nutr. 2001;40(4):161-7.
Wagner, K. H., Tomasch, R., & Elmadfa, I. (2001). Impact of diets containing corn oil or olive/sunflower oil mixture on the human plasma and lipoprotein lipid metabolism. European Journal of Nutrition, 40(4), pp. 161-7.
Wagner KH, Tomasch R, Elmadfa I. Impact of Diets Containing Corn Oil or Olive/sunflower Oil Mixture On the Human Plasma and Lipoprotein Lipid Metabolism. Eur J Nutr. 2001;40(4):161-7. PubMed PMID: 11905957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of diets containing corn oil or olive/sunflower oil mixture on the human plasma and lipoprotein lipid metabolism. AU - Wagner,K H, AU - Tomasch,R, AU - Elmadfa,I, PY - 2002/3/22/pubmed PY - 2002/4/12/medline PY - 2002/3/22/entrez SP - 161 EP - 7 JF - European journal of nutrition JO - Eur J Nutr VL - 40 IS - 4 N2 - BACKGROUND: The effects of monounsaturated fatty acids (MUFA) rich diets compared to those that are rich in polyunsaturated fatty acids (PUFA) as well as the effects of an intake of single oils compared to oil mixtures are controversially discussed and results are contradictory. AIM OF THIS STUDY: To evaluate the effects of a plant oil-mixture (olive/sunflower oil; saturated/monounsaturated/polyunsaturated (S/M/P) = 14:69:17) high in oleic acid but also showing a moderate content of polyunsaturated fatty acids (PUFA) in comparison with a single, PUFA rich corn oil (S/M/P = 13:33:54) used in a normal, balanced diet on human plasma and lipoprotein metabolism. METHODS: The double-blind designed study comprised 28 healthy, non-smoking young men aged between 19 and 31 years. After two weeks of adjustment (mixed, balanced diet: 11.6 MJ average, average fat intake approximately 105 g/d), the design included a two week test period in which a diet with 80 g corn oil/d vs a mixture of 68 g olive- and 12 g sunflower oil/d (total 80 g) as the main fat source was given, followed by a crossover after two weeks. Compliance and ingestion of diets were monitored by assessing the fatty acid pattern in LDL and by determination of alpha- and gamma-tocopherol in plasma and LDL. Results Diets were well incorporated due to the significant changes in plasma- and LDL-tocopherol levels and the significant different average ratio of oleic acid to linoleic acid in LDL. The PUFA-rich corn oil diet was able to reduce low density lipoprotein (LDL) cholesterol from adjustment to T2 significantly (p < 0.01), which was also confirmed by a trend after cross over (p=0.15). Total cholesterol (only after cross over at T3), total triglycerides (TG) and very low density lipoprotein (VLDL)-TG were significantly lower at T2 after the corn oil diet than after the mixed oil diet. Total high density lipoproteins (HDL) and HDL cholesterol remained unchanged by both diets. CONCLUSIONS: The results show that during the intervention of two weeks for each diet and the following cross over the corn oil diet had more influence on lipoprotein metabolism than the MUFA-rich diet. The hypocholesteremic effect of the PUFA-rich diet must also be connected with the high amount of unsaponifiable substances, mainly phytosterols in the corn oil. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/11905957/Impact_of_diets_containing_corn_oil_or_olive/sunflower_oil_mixture_on_the_human_plasma_and_lipoprotein_lipid_metabolism_ L2 - https://dx.doi.org/10.1007/s003940170004 DB - PRIME DP - Unbound Medicine ER -