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Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily.
J Am Acad Dermatol. 2002 Apr; 46(4):517-23.JA

Abstract

BACKGROUND

Finasteride, a type II 5alpha-reductase inhibitor, reduces scalp and serum dihydrotestosterone and has been shown to be effective in men with androgenetic alopecia (AGA).

OBJECTIVE

The purpose of this study was to determine the effect of finasteride on scalp hair weight in men with AGA.

METHODS

Sixty-six men with AGA received finasteride, 1 mg/d, or placebo in a 48-week study, and 49 men continued in a 48-week extension. Efficacy was assessed by scalp hair weights and hair counts.

RESULTS

As expected, hair counts improved with finasteride (net mean percent change +/- SE [95% CI] compared with placebo = 9.2% +/- 2.8% [3.8, 14.6] and 15.4% +/- 3.2% [9.1, 21.7] at 48 and 96 weeks, respectively; P <.01 for both time points), and net improvements in hair weight were greater (25.6% +/- 3.6% [18.5, 32.7] and 35.8% +/- 4.6% [26.7, 44.8] at 48 and 96 weeks, respectively; P <.001 for both time points). Finasteride was generally well tolerated.

CONCLUSION

In this study, finasteride, 1 mg, increased hair weight in men with AGA. Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs, such as increased growth rate (length) and thickness of hairs, contribute to the beneficial effects of finasteride in treated men.

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Authors+Show Affiliations

Price VH
University of California, San Francisco, CA, USA.
Menefee E
No affiliation info available
Sanchez M
No affiliation info available
Ruane P
No affiliation info available
Kaufman KD
No affiliation info available

MeSH

5-alpha Reductase InhibitorsAdultAlopeciaDouble-Blind MethodEnzyme InhibitorsFinasterideHairHumansMale

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11907500

Citation

Price, Vera H., et al. "Changes in Hair Weight and Hair Count in Men With Androgenetic Alopecia After Treatment With Finasteride, 1 Mg, Daily." Journal of the American Academy of Dermatology, vol. 46, no. 4, 2002, pp. 517-23.
Price VH, Menefee E, Sanchez M, et al. Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily. J Am Acad Dermatol. 2002;46(4):517-23.
Price, V. H., Menefee, E., Sanchez, M., Ruane, P., & Kaufman, K. D. (2002). Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily. Journal of the American Academy of Dermatology, 46(4), 517-23.
Price VH, et al. Changes in Hair Weight and Hair Count in Men With Androgenetic Alopecia After Treatment With Finasteride, 1 Mg, Daily. J Am Acad Dermatol. 2002;46(4):517-23. PubMed PMID: 11907500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily. AU - Price,Vera H, AU - Menefee,Emory, AU - Sanchez,Matilde, AU - Ruane,Patrick, AU - Kaufman,Keith D, PY - 2002/3/22/pubmed PY - 2002/5/4/medline PY - 2002/3/22/entrez SP - 517 EP - 23 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 46 IS - 4 N2 - BACKGROUND: Finasteride, a type II 5alpha-reductase inhibitor, reduces scalp and serum dihydrotestosterone and has been shown to be effective in men with androgenetic alopecia (AGA). OBJECTIVE: The purpose of this study was to determine the effect of finasteride on scalp hair weight in men with AGA. METHODS: Sixty-six men with AGA received finasteride, 1 mg/d, or placebo in a 48-week study, and 49 men continued in a 48-week extension. Efficacy was assessed by scalp hair weights and hair counts. RESULTS: As expected, hair counts improved with finasteride (net mean percent change +/- SE [95% CI] compared with placebo = 9.2% +/- 2.8% [3.8, 14.6] and 15.4% +/- 3.2% [9.1, 21.7] at 48 and 96 weeks, respectively; P <.01 for both time points), and net improvements in hair weight were greater (25.6% +/- 3.6% [18.5, 32.7] and 35.8% +/- 4.6% [26.7, 44.8] at 48 and 96 weeks, respectively; P <.001 for both time points). Finasteride was generally well tolerated. CONCLUSION: In this study, finasteride, 1 mg, increased hair weight in men with AGA. Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs, such as increased growth rate (length) and thickness of hairs, contribute to the beneficial effects of finasteride in treated men. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/11907500/Changes_in_hair_weight_and_hair_count_in_men_with_androgenetic_alopecia_after_treatment_with_finasteride_1_mg_daily_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(02)91072-8 DB - PRIME DP - Unbound Medicine ER -