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Effect of amoxicillin and co-amoxiclav on the aerobic and anaerobic nasopharyngeal flora.
J Antimicrob Chemother. 2002 Apr; 49(4):689-92.JA

Abstract

The effects of co-amoxiclav (AMC) and amoxicillin (AMX) therapy on the nasopharyngeal flora of children with acute otitis media (AOM) were compared. Nasopharyngeal culture for aerobic and anaerobic bacteria were obtained before therapy and 2-4 days after completion of antimicrobial therapy in 25 patients treated with either antibiotic. After therapy, 16 (64%) of the 25 patients treated with AMX and 23 (92%) of the 25 patients treated with AMC were considered clinically cured. Polymicrobial aerobic-anaerobic flora were present in all instances. A significant reduction in the number of both aerobic and anaerobic isolates occurred after therapy in those treated with AMX (177 isolates versus 133, P< 0.005) and AMC (172 isolates versus 60, P< 0.001). However, the number of all isolates recovered after therapy in those treated with AMC was significantly lower (60 isolates) than in those treated with AMX (133 isolates, P < 0.001). The recovery of known aerobic pathogens (e.g. Streptococcus pneumoniae, Staphylococcus aureus, beta-haemolytic streptococci, Haemophilus species and Moraxella catarrhalis) and penicillin-resistant bacteria after therapy was lower in the AMC group than in the AMX group (P < 0.005). This study illustrates the greater ability of AMC, compared with AMX, to reduce the number of potential nasopharyngeal pathogens and penicillin-resistant bacteria in children with AOM.

Authors+Show Affiliations

Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA. ib6@georgetown.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11909846

Citation

Brook, Itzhak, and Alan E. Gober. "Effect of Amoxicillin and Co-amoxiclav On the Aerobic and Anaerobic Nasopharyngeal Flora." The Journal of Antimicrobial Chemotherapy, vol. 49, no. 4, 2002, pp. 689-92.
Brook I, Gober AE. Effect of amoxicillin and co-amoxiclav on the aerobic and anaerobic nasopharyngeal flora. J Antimicrob Chemother. 2002;49(4):689-92.
Brook, I., & Gober, A. E. (2002). Effect of amoxicillin and co-amoxiclav on the aerobic and anaerobic nasopharyngeal flora. The Journal of Antimicrobial Chemotherapy, 49(4), 689-92.
Brook I, Gober AE. Effect of Amoxicillin and Co-amoxiclav On the Aerobic and Anaerobic Nasopharyngeal Flora. J Antimicrob Chemother. 2002;49(4):689-92. PubMed PMID: 11909846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of amoxicillin and co-amoxiclav on the aerobic and anaerobic nasopharyngeal flora. AU - Brook,Itzhak, AU - Gober,Alan E, PY - 2002/3/23/pubmed PY - 2002/9/27/medline PY - 2002/3/23/entrez SP - 689 EP - 92 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 49 IS - 4 N2 - The effects of co-amoxiclav (AMC) and amoxicillin (AMX) therapy on the nasopharyngeal flora of children with acute otitis media (AOM) were compared. Nasopharyngeal culture for aerobic and anaerobic bacteria were obtained before therapy and 2-4 days after completion of antimicrobial therapy in 25 patients treated with either antibiotic. After therapy, 16 (64%) of the 25 patients treated with AMX and 23 (92%) of the 25 patients treated with AMC were considered clinically cured. Polymicrobial aerobic-anaerobic flora were present in all instances. A significant reduction in the number of both aerobic and anaerobic isolates occurred after therapy in those treated with AMX (177 isolates versus 133, P< 0.005) and AMC (172 isolates versus 60, P< 0.001). However, the number of all isolates recovered after therapy in those treated with AMC was significantly lower (60 isolates) than in those treated with AMX (133 isolates, P < 0.001). The recovery of known aerobic pathogens (e.g. Streptococcus pneumoniae, Staphylococcus aureus, beta-haemolytic streptococci, Haemophilus species and Moraxella catarrhalis) and penicillin-resistant bacteria after therapy was lower in the AMC group than in the AMX group (P < 0.005). This study illustrates the greater ability of AMC, compared with AMX, to reduce the number of potential nasopharyngeal pathogens and penicillin-resistant bacteria in children with AOM. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/11909846/Effect_of_amoxicillin_and_co_amoxiclav_on_the_aerobic_and_anaerobic_nasopharyngeal_flora_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/49.4.689 DB - PRIME DP - Unbound Medicine ER -