Tags

Type your tag names separated by a space and hit enter

Does hypertension increase mortality risk from lung cancer? A prospective cohort study on smoking, hypertension and lung cancer risk among Korean men.
J Hypertens 2002; 20(4):617-22JH

Abstract

OBJECTIVE

To examine the effects of hypertension on lung cancer prospectively and to determine the interactive effect of hypertension and smoking on lung cancer risk.

DESIGN

A prospective cohort study.

PARTICIPANTS

The cohort comprised 452,645 Korean men, aged 35-64 years, who received health insurance from the Korea Medical Insurance Corporation and who had biennial medical evaluations in 1992 and 1994.

METHODS

Multivariate Cox proportional hazard models were tested, controlling for age, smoking status, exercise, body mass index, alcohol use, diabetes and serum cholesterol concentration.

MAIN OUTCOME MEASURE

Deaths from lung cancer.

RESULTS

At baseline, 261 080 persons (58.3%) were identified as current cigarette smokers. Between 1995 and 1999, 883 deaths from lung cancer (44.8/100,000 person-years) occurred. An initial finding indicated that hypertension increased the mortality risk of lung cancer [risk ratio (RR) 1.3, 95% confidence interval (CI) 1.1-1.5]. However, after stratification for smoking status, the risk ratio was increased only for current smokers (RR 1.4, 95% CI 1.2-1.6). When the interaction term was included in the multivariate model, there was a significant interactive effect of hypertension with current smoking (RR 1.8, 95% CI 1.0-3.1) on the risk of death from lung cancer, whereas the effect of hypertension itself did not attain significance.

CONCLUSION

Hypertension was not an independent risk factor in lung cancer-related deaths, but it increased the modest risk of lung cancer death among current smokers.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health, School of Medicine, The Ajou University, Suwon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11910295

Citation

Lee, Soon Young, et al. "Does Hypertension Increase Mortality Risk From Lung Cancer? a Prospective Cohort Study On Smoking, Hypertension and Lung Cancer Risk Among Korean Men." Journal of Hypertension, vol. 20, no. 4, 2002, pp. 617-22.
Lee SY, Kim MT, Jee SH, et al. Does hypertension increase mortality risk from lung cancer? A prospective cohort study on smoking, hypertension and lung cancer risk among Korean men. J Hypertens. 2002;20(4):617-22.
Lee, S. Y., Kim, M. T., Jee, S. H., & Im, J. S. (2002). Does hypertension increase mortality risk from lung cancer? A prospective cohort study on smoking, hypertension and lung cancer risk among Korean men. Journal of Hypertension, 20(4), pp. 617-22.
Lee SY, et al. Does Hypertension Increase Mortality Risk From Lung Cancer? a Prospective Cohort Study On Smoking, Hypertension and Lung Cancer Risk Among Korean Men. J Hypertens. 2002;20(4):617-22. PubMed PMID: 11910295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does hypertension increase mortality risk from lung cancer? A prospective cohort study on smoking, hypertension and lung cancer risk among Korean men. AU - Lee,Soon Young, AU - Kim,Miyong T, AU - Jee,Sun Ha, AU - Im,Jeong Soo, PY - 2002/3/23/pubmed PY - 2002/10/10/medline PY - 2002/3/23/entrez SP - 617 EP - 22 JF - Journal of hypertension JO - J. Hypertens. VL - 20 IS - 4 N2 - OBJECTIVE: To examine the effects of hypertension on lung cancer prospectively and to determine the interactive effect of hypertension and smoking on lung cancer risk. DESIGN: A prospective cohort study. PARTICIPANTS: The cohort comprised 452,645 Korean men, aged 35-64 years, who received health insurance from the Korea Medical Insurance Corporation and who had biennial medical evaluations in 1992 and 1994. METHODS: Multivariate Cox proportional hazard models were tested, controlling for age, smoking status, exercise, body mass index, alcohol use, diabetes and serum cholesterol concentration. MAIN OUTCOME MEASURE: Deaths from lung cancer. RESULTS: At baseline, 261 080 persons (58.3%) were identified as current cigarette smokers. Between 1995 and 1999, 883 deaths from lung cancer (44.8/100,000 person-years) occurred. An initial finding indicated that hypertension increased the mortality risk of lung cancer [risk ratio (RR) 1.3, 95% confidence interval (CI) 1.1-1.5]. However, after stratification for smoking status, the risk ratio was increased only for current smokers (RR 1.4, 95% CI 1.2-1.6). When the interaction term was included in the multivariate model, there was a significant interactive effect of hypertension with current smoking (RR 1.8, 95% CI 1.0-3.1) on the risk of death from lung cancer, whereas the effect of hypertension itself did not attain significance. CONCLUSION: Hypertension was not an independent risk factor in lung cancer-related deaths, but it increased the modest risk of lung cancer death among current smokers. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/11910295/Does_hypertension_increase_mortality_risk_from_lung_cancer_A_prospective_cohort_study_on_smoking_hypertension_and_lung_cancer_risk_among_Korean_men_ L2 - http://Insights.ovid.com/pubmed?pmid=11910295 DB - PRIME DP - Unbound Medicine ER -