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Mechanical ventilation in acute lung injury and ARDS. Tidal volume reduction.
Crit Care Clin. 2002 Jan; 18(1):1-13, v.CC

Abstract

Traditional mechanical ventilation practices used generous tidal volumes in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). This approach may have caused overdistention of aerated lung units, thus exacerbating lung injury in some patients. Several recent clinical trials of traditional versus lower tidal volume strategies in ALI/ARDS yielded disparate results. In the largest study, the lower tidal volume approach was associated with lower mortality and more ventilator-free days. This article reviews the rationale for tidal volume reduction in ALI/ARDS and the differences between the studies. Several different interpretations of the recent clinical trial results are addressed.

Authors+Show Affiliations

Department of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

11910724

Citation

Brower, Roy G.. "Mechanical Ventilation in Acute Lung Injury and ARDS. Tidal Volume Reduction." Critical Care Clinics, vol. 18, no. 1, 2002, pp. 1-13, v.
Brower RG. Mechanical ventilation in acute lung injury and ARDS. Tidal volume reduction. Crit Care Clin. 2002;18(1):1-13, v.
Brower, R. G. (2002). Mechanical ventilation in acute lung injury and ARDS. Tidal volume reduction. Critical Care Clinics, 18(1), 1-13, v.
Brower RG. Mechanical Ventilation in Acute Lung Injury and ARDS. Tidal Volume Reduction. Crit Care Clin. 2002;18(1):1-13, v. PubMed PMID: 11910724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanical ventilation in acute lung injury and ARDS. Tidal volume reduction. A1 - Brower,Roy G, PY - 2002/3/26/pubmed PY - 2002/9/24/medline PY - 2002/3/26/entrez SP - 1-13, v JF - Critical care clinics JO - Crit Care Clin VL - 18 IS - 1 N2 - Traditional mechanical ventilation practices used generous tidal volumes in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). This approach may have caused overdistention of aerated lung units, thus exacerbating lung injury in some patients. Several recent clinical trials of traditional versus lower tidal volume strategies in ALI/ARDS yielded disparate results. In the largest study, the lower tidal volume approach was associated with lower mortality and more ventilator-free days. This article reviews the rationale for tidal volume reduction in ALI/ARDS and the differences between the studies. Several different interpretations of the recent clinical trial results are addressed. SN - 0749-0704 UR - https://www.unboundmedicine.com/medline/citation/11910724/Mechanical_ventilation_in_acute_lung_injury_and_ARDS__Tidal_volume_reduction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0749-0704(03)00061-7 DB - PRIME DP - Unbound Medicine ER -