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[The significance of an elevated cobalamin concentration in the blood].
Ned Tijdschr Geneeskd. 2002 Mar 09; 146(10):459-64.NT

Abstract

Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Diseases such as chronic myeloid leukaemia, promyelocytic leukaemia, polycythaemia vera and hypereosinophilic syndrome are often accompanied by markedly elevated levels of cobalamin in the blood. A rise in the serum cobalamin concentration is one of the diagnostic criteria for polycythaemia vera and hypereosinophilic syndrome. In haematological disorders, the increase in circulating cobalamin levels is predominantly caused by enhanced production of haptocorrin. Several liver diseases such as acute hepatitis, cirrhosis of the liver, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin. In liver diseases, the increase in cobalamin is predominantly caused by cobalamin release during hepatic cytolysis and/or through decreased clearance of circulating cobalamin by the affected liver. Liver disorders are not an indication for determining the serum cobalamin concentration. However, a coincidentally observed elevated serum cobalamin concentration is reason for further investigation.

Authors+Show Affiliations

Amphia Ziekenhuis, Klinisch-Chemisch en Hematologisch Laboratorium, locatie Langendijk, Langendijk 75, 4819 EV Breda.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

dut

PubMed ID

11913109

Citation

Ermens, A A M., et al. "[The Significance of an Elevated Cobalamin Concentration in the Blood]." Nederlands Tijdschrift Voor Geneeskunde, vol. 146, no. 10, 2002, pp. 459-64.
Ermens AA, Vlasveld LT, van Marion-Kievit JA, et al. [The significance of an elevated cobalamin concentration in the blood]. Ned Tijdschr Geneeskd. 2002;146(10):459-64.
Ermens, A. A., Vlasveld, L. T., van Marion-Kievit, J. A., Lensen, C. J., & Lindemans, J. (2002). [The significance of an elevated cobalamin concentration in the blood]. Nederlands Tijdschrift Voor Geneeskunde, 146(10), 459-64.
Ermens AA, et al. [The Significance of an Elevated Cobalamin Concentration in the Blood]. Ned Tijdschr Geneeskd. 2002 Mar 9;146(10):459-64. PubMed PMID: 11913109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The significance of an elevated cobalamin concentration in the blood]. AU - Ermens,A A M, AU - Vlasveld,L Th, AU - van Marion-Kievit,J A, AU - Lensen,C J P A, AU - Lindemans,J, PY - 2002/3/27/pubmed PY - 2002/7/12/medline PY - 2002/3/27/entrez SP - 459 EP - 64 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 146 IS - 10 N2 - Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Diseases such as chronic myeloid leukaemia, promyelocytic leukaemia, polycythaemia vera and hypereosinophilic syndrome are often accompanied by markedly elevated levels of cobalamin in the blood. A rise in the serum cobalamin concentration is one of the diagnostic criteria for polycythaemia vera and hypereosinophilic syndrome. In haematological disorders, the increase in circulating cobalamin levels is predominantly caused by enhanced production of haptocorrin. Several liver diseases such as acute hepatitis, cirrhosis of the liver, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin. In liver diseases, the increase in cobalamin is predominantly caused by cobalamin release during hepatic cytolysis and/or through decreased clearance of circulating cobalamin by the affected liver. Liver disorders are not an indication for determining the serum cobalamin concentration. However, a coincidentally observed elevated serum cobalamin concentration is reason for further investigation. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/11913109/[The_significance_of_an_elevated_cobalamin_concentration_in_the_blood]_ L2 - https://medlineplus.gov/blooddisorders.html DB - PRIME DP - Unbound Medicine ER -