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Body fat distribution, insulin sensitivity, ovarian dysfunction and serum lipoproteins in patients with polycystic ovary syndrome.
Gynecol Endocrinol. 2002 Feb; 16(1):45-51.GE

Abstract

Polycystic ovary syndrome (PCOS) is characterized by various endocrine and metabolic abnormalities, whose mutual associations and symptoms are still not clear. In the present study, fifteen PCOS patients and fifteen controls, matched for age and body weight, were investigated. Endocrine profiles were evaluated by the nafarelin and the adrenocorticotropin (ACTH) test. Insulin sensitivity was determined by an intravenous insulin tolerance test. Patients showed a significant predominance of abdominal adiposity [waist-to-hip ratio (WHR), 0.86 +/- 0.05 vs. 0.79 +/- 0.04] with markedly higher fasting insulin levels (+75%) and reduced insulin sensitivity (-37%). Fasting insulin, testosterone and free androgen index were positively correlated with the body mass index (BMI). In contrast, insulin sensitivity and BMI were inversely correlated in patients only. In the nafarelin test increases of 17-OH-progesterone and androstenedione were higher in patients and positively correlated with fasting insulin levels. Lipoprotein profiles showed trends towards higher triglycerides, lower HDL-cholesterol and a preponderance of small, dense LDL in patients. In PCOS higher triglycerides and lower HDL cholesterol were correlated with insulin sensitivity. It is concluded that PCOS patients show metabolic abnormalities combined with a more adroid type of adiposity when compared to cyclic controls of similar BMI.

Authors+Show Affiliations

Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Vossstr. 9, 69115 Heidelberg, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11915581

Citation

Strowitzki, T, et al. "Body Fat Distribution, Insulin Sensitivity, Ovarian Dysfunction and Serum Lipoproteins in Patients With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 16, no. 1, 2002, pp. 45-51.
Strowitzki T, Halser B, Demant T. Body fat distribution, insulin sensitivity, ovarian dysfunction and serum lipoproteins in patients with polycystic ovary syndrome. Gynecol Endocrinol. 2002;16(1):45-51.
Strowitzki, T., Halser, B., & Demant, T. (2002). Body fat distribution, insulin sensitivity, ovarian dysfunction and serum lipoproteins in patients with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 16(1), 45-51.
Strowitzki T, Halser B, Demant T. Body Fat Distribution, Insulin Sensitivity, Ovarian Dysfunction and Serum Lipoproteins in Patients With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2002;16(1):45-51. PubMed PMID: 11915581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body fat distribution, insulin sensitivity, ovarian dysfunction and serum lipoproteins in patients with polycystic ovary syndrome. AU - Strowitzki,T, AU - Halser,B, AU - Demant,T, PY - 2002/3/28/pubmed PY - 2002/9/21/medline PY - 2002/3/28/entrez SP - 45 EP - 51 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 16 IS - 1 N2 - Polycystic ovary syndrome (PCOS) is characterized by various endocrine and metabolic abnormalities, whose mutual associations and symptoms are still not clear. In the present study, fifteen PCOS patients and fifteen controls, matched for age and body weight, were investigated. Endocrine profiles were evaluated by the nafarelin and the adrenocorticotropin (ACTH) test. Insulin sensitivity was determined by an intravenous insulin tolerance test. Patients showed a significant predominance of abdominal adiposity [waist-to-hip ratio (WHR), 0.86 +/- 0.05 vs. 0.79 +/- 0.04] with markedly higher fasting insulin levels (+75%) and reduced insulin sensitivity (-37%). Fasting insulin, testosterone and free androgen index were positively correlated with the body mass index (BMI). In contrast, insulin sensitivity and BMI were inversely correlated in patients only. In the nafarelin test increases of 17-OH-progesterone and androstenedione were higher in patients and positively correlated with fasting insulin levels. Lipoprotein profiles showed trends towards higher triglycerides, lower HDL-cholesterol and a preponderance of small, dense LDL in patients. In PCOS higher triglycerides and lower HDL cholesterol were correlated with insulin sensitivity. It is concluded that PCOS patients show metabolic abnormalities combined with a more adroid type of adiposity when compared to cyclic controls of similar BMI. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/11915581/Body_fat_distribution_insulin_sensitivity_ovarian_dysfunction_and_serum_lipoproteins_in_patients_with_polycystic_ovary_syndrome_ L2 - http://www.diseaseinfosearch.org/result/9619 DB - PRIME DP - Unbound Medicine ER -