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The origin of the spinal subdural space: ultrastructure findings.
Anesth Analg 2002; 94(4):991-5, table of contentsA&A

Abstract

Previous studies of samples from cranial meninges have created doubts about the existence of a virtual subdural space. We examined the ultrastructure of spinal meninges from three human cadavers immediately after death to see whether there is a virtual subdural space at this level. The arachnoid mater had two portions: a compact laminar portion covering the dural sac internal surface and a trabecular portion extending like a spider web around the pia mater. There was a cellular interface between the laminar arachnoid and the internal layer of the dura that we called the dura-arachnoid interface. There was no subdural space in those specimens where the dura mater was macroscopically in continuity with the arachnoid trabecules. In the specimens where the dura mater was separated from the arachnoid, we found fissures in between the neurothelial cells that extended throughout the interface. We hypothesize that the subdural space would have its origin within the dura-arachnoid interface when the neurothelial cells break up, creating in this way a real subdural space.

IMPLICATIONS

The subdural space was not seen under transmission electron microscopy in samples of human spinal meninges where surgical manipulation was avoided. Scanning electron microscopy in other samples showed the presence of broken neurothelial cells giving up fissures that extended along the dura-arachnoid interface. These findings may explain the origin of a real subdural space.

Authors+Show Affiliations

Department of Anesthesiology and Critical Care, Hospital General de Móstoles, Hospital de Madrid Montepríncipe, Spain. miguelangel.rei@terra.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11916810

Citation

Reina, Miguel Angel, et al. "The Origin of the Spinal Subdural Space: Ultrastructure Findings." Anesthesia and Analgesia, vol. 94, no. 4, 2002, 991-5, table of contents.
Reina MA, De Leon Casasola O, López A, et al. The origin of the spinal subdural space: ultrastructure findings. Anesth Analg. 2002;94(4):991-5, table of contents.
Reina, M. A., De Leon Casasola, O., López, A., De Andrés, J. A., Mora, M., & Fernández, A. (2002). The origin of the spinal subdural space: ultrastructure findings. Anesthesia and Analgesia, 94(4), 991-5, table of contents.
Reina MA, et al. The Origin of the Spinal Subdural Space: Ultrastructure Findings. Anesth Analg. 2002;94(4):991-5, table of contents. PubMed PMID: 11916810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The origin of the spinal subdural space: ultrastructure findings. AU - Reina,Miguel Angel, AU - De Leon Casasola,Oscar, AU - López,Andrés, AU - De Andrés,José Antonio, AU - Mora,Miguel, AU - Fernández,Agustín, PY - 2002/3/28/pubmed PY - 2002/4/20/medline PY - 2002/3/28/entrez SP - 991-5, table of contents JF - Anesthesia and analgesia JO - Anesth. Analg. VL - 94 IS - 4 N2 - UNLABELLED: Previous studies of samples from cranial meninges have created doubts about the existence of a virtual subdural space. We examined the ultrastructure of spinal meninges from three human cadavers immediately after death to see whether there is a virtual subdural space at this level. The arachnoid mater had two portions: a compact laminar portion covering the dural sac internal surface and a trabecular portion extending like a spider web around the pia mater. There was a cellular interface between the laminar arachnoid and the internal layer of the dura that we called the dura-arachnoid interface. There was no subdural space in those specimens where the dura mater was macroscopically in continuity with the arachnoid trabecules. In the specimens where the dura mater was separated from the arachnoid, we found fissures in between the neurothelial cells that extended throughout the interface. We hypothesize that the subdural space would have its origin within the dura-arachnoid interface when the neurothelial cells break up, creating in this way a real subdural space. IMPLICATIONS: The subdural space was not seen under transmission electron microscopy in samples of human spinal meninges where surgical manipulation was avoided. Scanning electron microscopy in other samples showed the presence of broken neurothelial cells giving up fissures that extended along the dura-arachnoid interface. These findings may explain the origin of a real subdural space. SN - 0003-2999 UR - https://www.unboundmedicine.com/medline/citation/11916810/The_origin_of_the_spinal_subdural_space:_ultrastructure_findings_ L2 - http://dx.doi.org/10.1097/00000539-200204000-00040 DB - PRIME DP - Unbound Medicine ER -