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Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight.
Diabetes. 2002 Apr; 51(4):1271-80.D

Abstract

Several studies have linked low birth weight (LBW) and type 2 diabetes. We investigated hepatic and peripheral insulin action including intracellular glucose metabolism in 40 19-year-old men (20 LBW, 20 matched control subjects), using the hyperinsulinemic-euglycemic clamp technique at two physiological insulin levels (10 and 40 mU/m(2) per min), indirect calorimetry, and [3-(3)H]glucose. Insulin secretion was examined during an oral and intravenous glucose tolerance test. Fasting p-glucose was higher in the LBW group (5.6 +/- 0.1 vs. 5.4 +/- 0.1; P < 0.05). Basal plasma glycerol concentrations were significantly lower in the LBW group. Insulin-stimulated glycolytic flux was significantly reduced, and suppression of endogenous glucose production was enhanced in the LBW group. Nevertheless, basal and insulin-stimulated rates of whole-body peripheral glucose disposal, glucose oxidation, lipid oxidation, exogenous glucose storage, and nonoxidative glucose metabolism were similar in the two groups. Insulin secretion was reduced by 30% in the LBW group, when expressed relative to insulin sensitivity (disposition index = insulin secretion x insulin action). We propose that reduced insulin-stimulated glycolysis precedes overt insulin resistance in LBW men. A lower insulin secretion may contribute to impaired glucose tolerance and ultimately lead to diabetes.

Authors+Show Affiliations

Department of Endocrinology and Clinical Research Unit, Hvidovre University Hospital, Hvidovre, Denmark. cbjensen@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11916955

Citation

Jensen, Christine B., et al. "Early Differential Defects of Insulin Secretion and Action in 19-year-old Caucasian Men Who Had Low Birth Weight." Diabetes, vol. 51, no. 4, 2002, pp. 1271-80.
Jensen CB, Storgaard H, Dela F, et al. Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight. Diabetes. 2002;51(4):1271-80.
Jensen, C. B., Storgaard, H., Dela, F., Holst, J. J., Madsbad, S., & Vaag, A. A. (2002). Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight. Diabetes, 51(4), 1271-80.
Jensen CB, et al. Early Differential Defects of Insulin Secretion and Action in 19-year-old Caucasian Men Who Had Low Birth Weight. Diabetes. 2002;51(4):1271-80. PubMed PMID: 11916955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight. AU - Jensen,Christine B, AU - Storgaard,Heidi, AU - Dela,Flemming, AU - Holst,Jens Juul, AU - Madsbad,Sten, AU - Vaag,Allan A, PY - 2002/3/28/pubmed PY - 2002/5/11/medline PY - 2002/3/28/entrez SP - 1271 EP - 80 JF - Diabetes JO - Diabetes VL - 51 IS - 4 N2 - Several studies have linked low birth weight (LBW) and type 2 diabetes. We investigated hepatic and peripheral insulin action including intracellular glucose metabolism in 40 19-year-old men (20 LBW, 20 matched control subjects), using the hyperinsulinemic-euglycemic clamp technique at two physiological insulin levels (10 and 40 mU/m(2) per min), indirect calorimetry, and [3-(3)H]glucose. Insulin secretion was examined during an oral and intravenous glucose tolerance test. Fasting p-glucose was higher in the LBW group (5.6 +/- 0.1 vs. 5.4 +/- 0.1; P < 0.05). Basal plasma glycerol concentrations were significantly lower in the LBW group. Insulin-stimulated glycolytic flux was significantly reduced, and suppression of endogenous glucose production was enhanced in the LBW group. Nevertheless, basal and insulin-stimulated rates of whole-body peripheral glucose disposal, glucose oxidation, lipid oxidation, exogenous glucose storage, and nonoxidative glucose metabolism were similar in the two groups. Insulin secretion was reduced by 30% in the LBW group, when expressed relative to insulin sensitivity (disposition index = insulin secretion x insulin action). We propose that reduced insulin-stimulated glycolysis precedes overt insulin resistance in LBW men. A lower insulin secretion may contribute to impaired glucose tolerance and ultimately lead to diabetes. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/11916955/Early_differential_defects_of_insulin_secretion_and_action_in_19_year_old_caucasian_men_who_had_low_birth_weight_ L2 - https://diabetes.diabetesjournals.org/lookup/pmidlookup?view=long&amp;pmid=11916955 DB - PRIME DP - Unbound Medicine ER -