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Effect of a chicken-based diet on renal function and lipid profile in patients with type 2 diabetes: a randomized crossover trial.
Diabetes Care. 2002 Apr; 25(4):645-51.DC

Abstract

OBJECTIVE

To assess the effect of replacing red meat with chicken in the usual diet and the effect of a low-protein diet on glomerular filtration rate (GFR), urinary albumin excretion rate (UAER), and lipid levels in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS

A randomized, crossover, controlled trial was conducted with 28 patients with type 2 diabetes (seven women; mean age 58.1 years): 15 patients were normoalbuminuric (UAER <20 microg/min), and 13 patients were microalbuminuric (UAER 20-200 microg/min). A chicken-based diet (red meat replaced with chicken) and a low-protein diet were compared with the patients' usual diet. Patients followed each diet for 4 weeks with a 4-week washout period between. GFR ((51)Cr-EDTA single-injection technique), 24-h UAER (immunoturbidimetry), apolipoprotein B, total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were measured after each diet.

RESULTS

Normoalbuminuric and microalbuminuric patients with diabetes were analyzed separately. In normoalbuminuric patients, GFR after the chicken (101.3 +/- 22.9 ml x min(-1) x 1.73 m(-2)) and low-protein diets (93.8 +/- 20.5 ml x min(-1) x m(-2)) was lower than after the usual diet (113.4 +/- 31.4 ml x min(-1) x 1.73 m(-2); P < 0.05). In microalbuminuric patients, apolipoprotein B levels were lower after the chicken (113.5 +/- 36.0 mg/dl) and low-protein diets (103.5 +/- 40.1 mg/dl) than after the usual diet (134.3 +/- 30.7 mg/dl; P < 0.05). Only the chicken diet reduced UAER (median 34.3 microg/min) compared with the low-protein (median 52.3 microg/min) and usual (median 63.8 microg/min) diets (P < 0.05). Glycemic control and blood pressure did not change after the diets.

CONCLUSIONS

A normoproteic diet with chicken as the only source of meat may represent an alternative strategy for treatment of patients with type 2 diabetes and microalbuminuria.

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Authors+Show Affiliations

Gross JL
Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Zelmanovitz T
No affiliation info available
Moulin CC
No affiliation info available
De Mello V
No affiliation info available
Perassolo M
No affiliation info available
Leitão C
No affiliation info available
Hoefel A
No affiliation info available
Paggi A
No affiliation info available
Azevedo MJ
No affiliation info available

MeSH

AdultAlbuminuriaAnimalsApolipoproteins BBlood GlucoseBlood PressureChickensCholesterolCross-Over StudiesDiabetes Mellitus, Type 2Dietary ProteinsFemaleFructosamineGlomerular Filtration RateGlycated Hemoglobin AHumansLipoproteins, HDLLipoproteins, LDLMaleMeatMiddle AgedPoultryReference ValuesSmokingTriglycerides

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11919119

Clinical Trial Links

Chicken-Diet vs. Enalapril to Reduce Albuminuria

Citation

Gross, Jorge L., et al. "Effect of a Chicken-based Diet On Renal Function and Lipid Profile in Patients With Type 2 Diabetes: a Randomized Crossover Trial." Diabetes Care, vol. 25, no. 4, 2002, pp. 645-51.
Gross JL, Zelmanovitz T, Moulin CC, et al. Effect of a chicken-based diet on renal function and lipid profile in patients with type 2 diabetes: a randomized crossover trial. Diabetes Care. 2002;25(4):645-51.
Gross, J. L., Zelmanovitz, T., Moulin, C. C., De Mello, V., Perassolo, M., Leitão, C., Hoefel, A., Paggi, A., & Azevedo, M. J. (2002). Effect of a chicken-based diet on renal function and lipid profile in patients with type 2 diabetes: a randomized crossover trial. Diabetes Care, 25(4), 645-51.
Gross JL, et al. Effect of a Chicken-based Diet On Renal Function and Lipid Profile in Patients With Type 2 Diabetes: a Randomized Crossover Trial. Diabetes Care. 2002;25(4):645-51. PubMed PMID: 11919119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a chicken-based diet on renal function and lipid profile in patients with type 2 diabetes: a randomized crossover trial. AU - Gross,Jorge L, AU - Zelmanovitz,Themis, AU - Moulin,Cileide C, AU - De Mello,Vanessa, AU - Perassolo,Magda, AU - Leitão,Cristiane, AU - Hoefel,Alice, AU - Paggi,Alexandre, AU - Azevedo,Mirela J, PY - 2002/3/29/pubmed PY - 2002/8/1/medline PY - 2002/3/29/entrez SP - 645 EP - 51 JF - Diabetes care JO - Diabetes Care VL - 25 IS - 4 N2 - OBJECTIVE: To assess the effect of replacing red meat with chicken in the usual diet and the effect of a low-protein diet on glomerular filtration rate (GFR), urinary albumin excretion rate (UAER), and lipid levels in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A randomized, crossover, controlled trial was conducted with 28 patients with type 2 diabetes (seven women; mean age 58.1 years): 15 patients were normoalbuminuric (UAER <20 microg/min), and 13 patients were microalbuminuric (UAER 20-200 microg/min). A chicken-based diet (red meat replaced with chicken) and a low-protein diet were compared with the patients' usual diet. Patients followed each diet for 4 weeks with a 4-week washout period between. GFR ((51)Cr-EDTA single-injection technique), 24-h UAER (immunoturbidimetry), apolipoprotein B, total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were measured after each diet. RESULTS: Normoalbuminuric and microalbuminuric patients with diabetes were analyzed separately. In normoalbuminuric patients, GFR after the chicken (101.3 +/- 22.9 ml x min(-1) x 1.73 m(-2)) and low-protein diets (93.8 +/- 20.5 ml x min(-1) x m(-2)) was lower than after the usual diet (113.4 +/- 31.4 ml x min(-1) x 1.73 m(-2); P < 0.05). In microalbuminuric patients, apolipoprotein B levels were lower after the chicken (113.5 +/- 36.0 mg/dl) and low-protein diets (103.5 +/- 40.1 mg/dl) than after the usual diet (134.3 +/- 30.7 mg/dl; P < 0.05). Only the chicken diet reduced UAER (median 34.3 microg/min) compared with the low-protein (median 52.3 microg/min) and usual (median 63.8 microg/min) diets (P < 0.05). Glycemic control and blood pressure did not change after the diets. CONCLUSIONS: A normoproteic diet with chicken as the only source of meat may represent an alternative strategy for treatment of patients with type 2 diabetes and microalbuminuria. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/11919119/Effect_of_a_chicken_based_diet_on_renal_function_and_lipid_profile_in_patients_with_type_2_diabetes:_a_randomized_crossover_trial_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=11919119 DB - PRIME DP - Unbound Medicine ER -