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Postmenopausal cancer risk after self-reported endometriosis diagnosis in the Iowa Women's Health Study.

Abstract

BACKGROUND

Endometriosis, the presence of endometrial tissue outside the uterus, has an estimated prevalence between 4% and 10%. A recent study reported that women with a hospital discharge diagnosis of endometriosis were at increased risk of cancer at any site, breast cancer, ovarian cancer, and hematopoietic malignancies, especially non-Hodgkin lymphoma (NHL).

METHODS

The authors examined whether self-reported diagnosis of endometriosis was associated with increased risk of various cancers in the Iowa Women's Health Study. Incident cancer cases were identified from 1986 through 1998. Cox proportional hazards regression models were used to calculate relative risks and 95% confidence intervals for the particular cancers of interest.

RESULTS

Of 37,434 participants in this analysis, 3.8% reported a history of endometriosis at baseline in 1986. After 13 years of follow-up, 1795 breast, 188 ovarian, and 243 NHL cases were detected in the cohort. Endometriosis was not associated with risk of all cancers combined (age-adjusted relative risk [RR], 0.9; 95% confidence interval [CI], 0.7-1.2), breast carcinoma (RR, 1.0; 95% CI, 0.8-1.3), or ovarian carcinoma (RR, 0.8; 95% CI, 0.2-2.4). However, endometriosis was significantly associated with risk of NHL (age-adjusted RR, 1.8; 95% CI, 1.0-3.0), especially diffuse NHL (RR, 3.2; 95% CI, 1.8-5.6). Multivariate adjustment had minimal effect on the point estimates of risk (NHL RR, 1.7; 95% CI, 0.97-2.7; diffuse NHL RR, 3.3; 95% CI, 1.9-5.9). Endometriosis was not associated with elevated risk of lung, urinary tract, endometrial, melanoma, or colorectal carcinomas (RRs, 1.2, 0.8, 1.2, 0.7, and 0.7, respectively).

CONCLUSIONS

These results corroborate a previously reported association between endometriosis and increased risk of NHL but not cancer at other sites.

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  • Authors+Show Affiliations

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    Mayo Foundation, Health Sciences Research, Rochester, Minnesota 55905, USA.

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    Source

    Cancer 94:5 2002 Mar 01 pg 1612-8

    MeSH

    Aged
    Breast Neoplasms
    Cohort Studies
    Endometriosis
    Female
    Health Surveys
    Humans
    Incidence
    Lymphoma, Non-Hodgkin
    Middle Aged
    Ovarian Neoplasms
    Postmenopause
    Risk Assessment

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11920519

    Citation

    Olson, Janet E., et al. "Postmenopausal Cancer Risk After Self-reported Endometriosis Diagnosis in the Iowa Women's Health Study." Cancer, vol. 94, no. 5, 2002, pp. 1612-8.
    Olson JE, Cerhan JR, Janney CA, et al. Postmenopausal cancer risk after self-reported endometriosis diagnosis in the Iowa Women's Health Study. Cancer. 2002;94(5):1612-8.
    Olson, J. E., Cerhan, J. R., Janney, C. A., Anderson, K. E., Vachon, C. M., & Sellers, T. A. (2002). Postmenopausal cancer risk after self-reported endometriosis diagnosis in the Iowa Women's Health Study. Cancer, 94(5), pp. 1612-8.
    Olson JE, et al. Postmenopausal Cancer Risk After Self-reported Endometriosis Diagnosis in the Iowa Women's Health Study. Cancer. 2002 Mar 1;94(5):1612-8. PubMed PMID: 11920519.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Postmenopausal cancer risk after self-reported endometriosis diagnosis in the Iowa Women's Health Study. AU - Olson,Janet E, AU - Cerhan,James R, AU - Janney,Carol A, AU - Anderson,Kristin E, AU - Vachon,Celine M, AU - Sellers,Thomas A, PY - 2002/3/29/pubmed PY - 2002/4/11/medline PY - 2002/3/29/entrez SP - 1612 EP - 8 JF - Cancer JO - Cancer VL - 94 IS - 5 N2 - BACKGROUND: Endometriosis, the presence of endometrial tissue outside the uterus, has an estimated prevalence between 4% and 10%. A recent study reported that women with a hospital discharge diagnosis of endometriosis were at increased risk of cancer at any site, breast cancer, ovarian cancer, and hematopoietic malignancies, especially non-Hodgkin lymphoma (NHL). METHODS: The authors examined whether self-reported diagnosis of endometriosis was associated with increased risk of various cancers in the Iowa Women's Health Study. Incident cancer cases were identified from 1986 through 1998. Cox proportional hazards regression models were used to calculate relative risks and 95% confidence intervals for the particular cancers of interest. RESULTS: Of 37,434 participants in this analysis, 3.8% reported a history of endometriosis at baseline in 1986. After 13 years of follow-up, 1795 breast, 188 ovarian, and 243 NHL cases were detected in the cohort. Endometriosis was not associated with risk of all cancers combined (age-adjusted relative risk [RR], 0.9; 95% confidence interval [CI], 0.7-1.2), breast carcinoma (RR, 1.0; 95% CI, 0.8-1.3), or ovarian carcinoma (RR, 0.8; 95% CI, 0.2-2.4). However, endometriosis was significantly associated with risk of NHL (age-adjusted RR, 1.8; 95% CI, 1.0-3.0), especially diffuse NHL (RR, 3.2; 95% CI, 1.8-5.6). Multivariate adjustment had minimal effect on the point estimates of risk (NHL RR, 1.7; 95% CI, 0.97-2.7; diffuse NHL RR, 3.3; 95% CI, 1.9-5.9). Endometriosis was not associated with elevated risk of lung, urinary tract, endometrial, melanoma, or colorectal carcinomas (RRs, 1.2, 0.8, 1.2, 0.7, and 0.7, respectively). CONCLUSIONS: These results corroborate a previously reported association between endometriosis and increased risk of NHL but not cancer at other sites. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/11920519/Postmenopausal_cancer_risk_after_self_reported_endometriosis_diagnosis_in_the_Iowa_Women's_Health_Study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0008-543X&date=2002&volume=94&issue=5&spage=1612 DB - PRIME DP - Unbound Medicine ER -