Tags

Type your tag names separated by a space and hit enter

LPL polymorphism predicts stroke risk in men.
Genet Epidemiol. 2002 Mar; 22(3):233-42.GE

Abstract

Variation in lipid levels has been associated with atherosclerotic vascular disease, including stroke. Genes contributing to interindividual variation in lipid levels may play a role in the etiology of stroke, either through their effects on lipid synthesis and metabolism or through separate pathways. For this reason, we sought to examine the association between polymorphisms in the lipoprotein lipase (LPL) and apolipoprotein E (APOE) genes and subclinical and clinical stroke in the Atherosclerosis Risk in Communities (ARIC) Study. Subclinical stroke was determined by cerebral magnetic resonance imaging (MRI). Subclinical cerebral infarct cases (n = 197) were compared to a stratified random sample identified from individuals participating in the MRI examination (n = 200). Incidence of clinical ischemic stroke was determined by following the ARIC cohort for an average of 7.5 years for potential cerebrovascular events; 218 validated clinical ischemic strokes were identified. A stratified random sample of the ARIC cohort (CRS, n = 964) was used as the comparison group for clinical cases. The LPL S291-carrying genotypes and APOE epsilon2- and epsilon4-carrying genotypes were not significantly associated with subclinical or clinical stroke. The LPL X447-containing genotypes were significantly associated with subclinical (odds ratio [OR], 4.32; 95% confidence interval [CI], 1.23-15.15; P = 0.020) and clinical stroke (hazard rate ratio [HRR], 2.57; 95% CI, 1.24-5.34; P = 0.01) in men, both by themselves and after adjustment for multiple stroke risk factors. The LPL S447X polymorphism is significantly associated with subclinical cerebral infarction and incident clinical ischemic stroke in men from a middle-aged American population. This association does not appear to be mediated by triglyceride, high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol levels, or additional stroke risk factors.

Authors+Show Affiliations

Human Genetics Center, University of Texas-Houston Health Science Center, Houston, Texas 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11921083

Citation

Morrison, Alanna C., et al. "LPL Polymorphism Predicts Stroke Risk in Men." Genetic Epidemiology, vol. 22, no. 3, 2002, pp. 233-42.
Morrison AC, Ballantyne CM, Bray M, et al. LPL polymorphism predicts stroke risk in men. Genet Epidemiol. 2002;22(3):233-42.
Morrison, A. C., Ballantyne, C. M., Bray, M., Chambless, L. E., Sharrett, A. R., & Boerwinkle, E. (2002). LPL polymorphism predicts stroke risk in men. Genetic Epidemiology, 22(3), 233-42.
Morrison AC, et al. LPL Polymorphism Predicts Stroke Risk in Men. Genet Epidemiol. 2002;22(3):233-42. PubMed PMID: 11921083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - LPL polymorphism predicts stroke risk in men. AU - Morrison,Alanna C, AU - Ballantyne,Christie M, AU - Bray,Molly, AU - Chambless,Lloyd E, AU - Sharrett,A Richey, AU - Boerwinkle,Eric, PY - 2002/3/29/pubmed PY - 2002/5/15/medline PY - 2002/3/29/entrez SP - 233 EP - 42 JF - Genetic epidemiology JO - Genet Epidemiol VL - 22 IS - 3 N2 - Variation in lipid levels has been associated with atherosclerotic vascular disease, including stroke. Genes contributing to interindividual variation in lipid levels may play a role in the etiology of stroke, either through their effects on lipid synthesis and metabolism or through separate pathways. For this reason, we sought to examine the association between polymorphisms in the lipoprotein lipase (LPL) and apolipoprotein E (APOE) genes and subclinical and clinical stroke in the Atherosclerosis Risk in Communities (ARIC) Study. Subclinical stroke was determined by cerebral magnetic resonance imaging (MRI). Subclinical cerebral infarct cases (n = 197) were compared to a stratified random sample identified from individuals participating in the MRI examination (n = 200). Incidence of clinical ischemic stroke was determined by following the ARIC cohort for an average of 7.5 years for potential cerebrovascular events; 218 validated clinical ischemic strokes were identified. A stratified random sample of the ARIC cohort (CRS, n = 964) was used as the comparison group for clinical cases. The LPL S291-carrying genotypes and APOE epsilon2- and epsilon4-carrying genotypes were not significantly associated with subclinical or clinical stroke. The LPL X447-containing genotypes were significantly associated with subclinical (odds ratio [OR], 4.32; 95% confidence interval [CI], 1.23-15.15; P = 0.020) and clinical stroke (hazard rate ratio [HRR], 2.57; 95% CI, 1.24-5.34; P = 0.01) in men, both by themselves and after adjustment for multiple stroke risk factors. The LPL S447X polymorphism is significantly associated with subclinical cerebral infarction and incident clinical ischemic stroke in men from a middle-aged American population. This association does not appear to be mediated by triglyceride, high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol levels, or additional stroke risk factors. SN - 0741-0395 UR - https://www.unboundmedicine.com/medline/citation/11921083/LPL_polymorphism_predicts_stroke_risk_in_men_ L2 - https://doi.org/10.1002/gepi.0191 DB - PRIME DP - Unbound Medicine ER -