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Selenoprotein levels in patients with colorectal adenomas and cancer.

Abstract

OBJECTIVES

Selenium is a trace mineral that, as a constituent of certain selenoproteins, acts as an antioxidant. Results of studies addressing a cancer protective effect of selenium have been controversial. The present study measured selenoprotein-P, extracellular glutathione peroxidase, and plasma selenium in patients with colon cancer and adenomatous colon polyps to determine whether patients who develop colorectal adenomas or cancer are selenium deficient.

METHODS

Patients who presented to an endoscopy center for colonoscopy or who were referred to our institution with a newly diagnosed colorectal cancer were offered enrollment in the trial. Each patient underwent phlebotomy, usually immediately after colonoscopy. In all, 103 patients were enrolled in the study. Of these, 33 patients were found to have colorectal cancer, 35 adenomatous colon polyps, and 17 normal examinations. A total of 18 patients had other diagnoses and were not included in the study group.

RESULTS

The mean age for the colorectal cancer group was 69 yr, for the adenomatous colon polyp group 62 yr, and for the normal group was 56 yr. The adenomatous colon polyp and normal groups were predominantly female. Based on one way analysis of variance tests, there was no significant difference in selenoprotein-P or plasma selenium levels or extracellular glutathione peroxidase activity among the three groups (p = 0.28, 0.098, and 0.35 respectively).

CONCLUSIONS

The present data suggest that patients with adenomatous colon polyps and those with colorectal cancer are not selenium deficient.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    University of Missouri, Columbia, USA.

    , ,

    Source

    MeSH

    Adenoma
    Adenomatous Polyposis Coli
    Aged
    Aged, 80 and over
    Antioxidants
    Blood Proteins
    Colorectal Neoplasms
    Deficiency Diseases
    Female
    Glutathione Peroxidase
    Humans
    Male
    Middle Aged
    Proteins
    Selenium
    Selenoprotein P
    Selenoproteins

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11922572

    Citation

    Early, Dayna S., et al. "Selenoprotein Levels in Patients With Colorectal Adenomas and Cancer." The American Journal of Gastroenterology, vol. 97, no. 3, 2002, pp. 745-8.
    Early DS, Hill K, Burk R, et al. Selenoprotein levels in patients with colorectal adenomas and cancer. Am J Gastroenterol. 2002;97(3):745-8.
    Early, D. S., Hill, K., Burk, R., & Palmer, I. (2002). Selenoprotein levels in patients with colorectal adenomas and cancer. The American Journal of Gastroenterology, 97(3), pp. 745-8.
    Early DS, et al. Selenoprotein Levels in Patients With Colorectal Adenomas and Cancer. Am J Gastroenterol. 2002;97(3):745-8. PubMed PMID: 11922572.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Selenoprotein levels in patients with colorectal adenomas and cancer. AU - Early,Dayna S, AU - Hill,Kristina, AU - Burk,Raymond, AU - Palmer,Ivan, PY - 2002/4/2/pubmed PY - 2002/4/20/medline PY - 2002/4/2/entrez SP - 745 EP - 8 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 97 IS - 3 N2 - OBJECTIVES: Selenium is a trace mineral that, as a constituent of certain selenoproteins, acts as an antioxidant. Results of studies addressing a cancer protective effect of selenium have been controversial. The present study measured selenoprotein-P, extracellular glutathione peroxidase, and plasma selenium in patients with colon cancer and adenomatous colon polyps to determine whether patients who develop colorectal adenomas or cancer are selenium deficient. METHODS: Patients who presented to an endoscopy center for colonoscopy or who were referred to our institution with a newly diagnosed colorectal cancer were offered enrollment in the trial. Each patient underwent phlebotomy, usually immediately after colonoscopy. In all, 103 patients were enrolled in the study. Of these, 33 patients were found to have colorectal cancer, 35 adenomatous colon polyps, and 17 normal examinations. A total of 18 patients had other diagnoses and were not included in the study group. RESULTS: The mean age for the colorectal cancer group was 69 yr, for the adenomatous colon polyp group 62 yr, and for the normal group was 56 yr. The adenomatous colon polyp and normal groups were predominantly female. Based on one way analysis of variance tests, there was no significant difference in selenoprotein-P or plasma selenium levels or extracellular glutathione peroxidase activity among the three groups (p = 0.28, 0.098, and 0.35 respectively). CONCLUSIONS: The present data suggest that patients with adenomatous colon polyps and those with colorectal cancer are not selenium deficient. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/11922572/Selenoprotein_levels_in_patients_with_colorectal_adenomas_and_cancer_ L2 - http://Insights.ovid.com/pubmed?pmid=11922572 DB - PRIME DP - Unbound Medicine ER -