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Effect of dietary zeaxanthin on tissue distribution of zeaxanthin and lutein in quail.
Invest Ophthalmol Vis Sci. 2002 Apr; 43(4):1210-21.IO

Abstract

PURPOSE

The xanthophyll carotenoids (lutein and zeaxanthin) are hypothesized to delay progression of age-related macular degeneration. The quail has a cone-dominant retina that accumulates carotenoids. The purpose of these experiments was to characterize the carotenoid composition of retina, serum, liver, and fat in quail and to determine whether dietary enrichment with zeaxanthin alters zeaxanthin or lutein concentrations in these tissues.

METHODS

Quail were fed for 6 months with a commercial turkey diet (T group; n = 8), carotenoid-deficient diet (C- group; n = 8), or a carotenoid-deficient diet supplemented with 35 mg 3R,3'R-zeaxanthin per kilogram of food, (Z+ group; n = 8). Zeaxanthin was derived from Sphingobacterium multivorum (basonym Flavobacterium). Carotenoids in serum, retina, liver, and fat were analyzed by HPLC.

RESULTS

As in the primate fovea, the retina accumulated zeaxanthin, lutein, and cryptoxanthin, and preferentially absorbed zeaxanthin (P < 0.005). In contrast, lutein was preferentially absorbed by liver (P < 0.01) and fat (P < 0.0001). In supplemented females, zeaxanthin increased approximately 4-fold in retina, and 74-, 63- and 22-fold in serum, liver, and fat, respectively. In males, zeaxanthin was elevated approximately 3-fold in retina, and 42-, 17-, and 12-fold in serum, liver, and fat, respectively. Birds fed the Z+ diet absorbed a higher fraction of dietary lutein into serum, but lutein was reduced in the retina (P < 0.05).

CONCLUSIONS

Xanthophyll profiles in quail mimic those in primates. Dietary supplements of zeaxanthin effectively increased zeaxanthin concentrations in serum, retina, liver, and fat. The robust response to zeaxanthin supplementation identifies the quail as an animal model for exploration of factors regulating delivery of dietary carotenoids to the retina.

Authors+Show Affiliations

Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11923268

Citation

Toyoda, Yoko, et al. "Effect of Dietary Zeaxanthin On Tissue Distribution of Zeaxanthin and Lutein in Quail." Investigative Ophthalmology & Visual Science, vol. 43, no. 4, 2002, pp. 1210-21.
Toyoda Y, Thomson LR, Langner A, et al. Effect of dietary zeaxanthin on tissue distribution of zeaxanthin and lutein in quail. Invest Ophthalmol Vis Sci. 2002;43(4):1210-21.
Toyoda, Y., Thomson, L. R., Langner, A., Craft, N. E., Garnett, K. M., Nichols, C. R., Cheng, K. M., & Dorey, C. K. (2002). Effect of dietary zeaxanthin on tissue distribution of zeaxanthin and lutein in quail. Investigative Ophthalmology & Visual Science, 43(4), 1210-21.
Toyoda Y, et al. Effect of Dietary Zeaxanthin On Tissue Distribution of Zeaxanthin and Lutein in Quail. Invest Ophthalmol Vis Sci. 2002;43(4):1210-21. PubMed PMID: 11923268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary zeaxanthin on tissue distribution of zeaxanthin and lutein in quail. AU - Toyoda,Yoko, AU - Thomson,Lauren R, AU - Langner,Andrea, AU - Craft,Neal E, AU - Garnett,Kevin M, AU - Nichols,Cathleen R, AU - Cheng,Kimberly M, AU - Dorey,C Kathleen, PY - 2002/3/30/pubmed PY - 2002/5/1/medline PY - 2002/3/30/entrez SP - 1210 EP - 21 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 43 IS - 4 N2 - PURPOSE: The xanthophyll carotenoids (lutein and zeaxanthin) are hypothesized to delay progression of age-related macular degeneration. The quail has a cone-dominant retina that accumulates carotenoids. The purpose of these experiments was to characterize the carotenoid composition of retina, serum, liver, and fat in quail and to determine whether dietary enrichment with zeaxanthin alters zeaxanthin or lutein concentrations in these tissues. METHODS: Quail were fed for 6 months with a commercial turkey diet (T group; n = 8), carotenoid-deficient diet (C- group; n = 8), or a carotenoid-deficient diet supplemented with 35 mg 3R,3'R-zeaxanthin per kilogram of food, (Z+ group; n = 8). Zeaxanthin was derived from Sphingobacterium multivorum (basonym Flavobacterium). Carotenoids in serum, retina, liver, and fat were analyzed by HPLC. RESULTS: As in the primate fovea, the retina accumulated zeaxanthin, lutein, and cryptoxanthin, and preferentially absorbed zeaxanthin (P < 0.005). In contrast, lutein was preferentially absorbed by liver (P < 0.01) and fat (P < 0.0001). In supplemented females, zeaxanthin increased approximately 4-fold in retina, and 74-, 63- and 22-fold in serum, liver, and fat, respectively. In males, zeaxanthin was elevated approximately 3-fold in retina, and 42-, 17-, and 12-fold in serum, liver, and fat, respectively. Birds fed the Z+ diet absorbed a higher fraction of dietary lutein into serum, but lutein was reduced in the retina (P < 0.05). CONCLUSIONS: Xanthophyll profiles in quail mimic those in primates. Dietary supplements of zeaxanthin effectively increased zeaxanthin concentrations in serum, retina, liver, and fat. The robust response to zeaxanthin supplementation identifies the quail as an animal model for exploration of factors regulating delivery of dietary carotenoids to the retina. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/11923268/Effect_of_dietary_zeaxanthin_on_tissue_distribution_of_zeaxanthin_and_lutein_in_quail_ L2 - http://iovs.arvojournals.org/article.aspx?volume=43&amp;page=1210 DB - PRIME DP - Unbound Medicine ER -