Tags

Type your tag names separated by a space and hit enter

Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens.
Alcohol Clin Exp Res. 2002 Mar; 26(3):394-9.AC

Abstract

BACKGROUND

Alcoholism is associated with a higher incidence of smoking. The mesolimbic dopaminergic pathway is believed to play an important role in the reinforcing effects of both ethanol and nicotine. This study was undertaken to determine whether simultaneous administration of systemic ethanol and microinjection of nicotine into the ventral tegmental area (VTA) would result in exaggerated release of dopamine (DA) in the shell region of nucleus accumbens.

METHODS

Microdialysis was applied in awake, freely moving adult male Wistar rats, and DA concentration in the dialysate was measured by HPLC-electrochemical detectors.

RESULTS

Systemic administration of ethanol or microinjection of nicotine into VTA resulted in a dose-dependent increase in DA release (extracellular DA concentration). Simultaneous administration of lower doses of nicotine and ethanol resulted in an additive effect on the released DA. This additive effect was not observed with higher doses of nicotine and ethanol. Administration of the nicotinic antagonist mecamylamine into VTA completely blocked ethanol-induced DA release.

CONCLUSIONS

These data support the hypothesis that the reinforcing effects of ethanol are at least partially mediated through the nicotinic receptors in the VTA. Furthermore, administration of selective nicotinic antagonists may be of therapeutic potential in reducing the rewarding effects of ethanol. The data also suggest that the combined effects of ethanol and nicotine on the "reward pathway" may be a contributing factor to the high incidence of smoking in alcoholics.

Authors+Show Affiliations

Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA. ytizabi@howard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11923594

Citation

Tizabi, Yousef, et al. "Effects of Combined Systemic Alcohol and Central Nicotine Administration Into Ventral Tegmental Area On Dopamine Release in the Nucleus Accumbens." Alcoholism, Clinical and Experimental Research, vol. 26, no. 3, 2002, pp. 394-9.
Tizabi Y, Copeland RL, Louis VA, et al. Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res. 2002;26(3):394-9.
Tizabi, Y., Copeland, R. L., Louis, V. A., & Taylor, R. E. (2002). Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. Alcoholism, Clinical and Experimental Research, 26(3), 394-9.
Tizabi Y, et al. Effects of Combined Systemic Alcohol and Central Nicotine Administration Into Ventral Tegmental Area On Dopamine Release in the Nucleus Accumbens. Alcohol Clin Exp Res. 2002;26(3):394-9. PubMed PMID: 11923594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. AU - Tizabi,Yousef, AU - Copeland,Robert L,Jr AU - Louis,Vely A, AU - Taylor,Robert E, PY - 2002/3/30/pubmed PY - 2002/7/26/medline PY - 2002/3/30/entrez SP - 394 EP - 9 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 26 IS - 3 N2 - BACKGROUND: Alcoholism is associated with a higher incidence of smoking. The mesolimbic dopaminergic pathway is believed to play an important role in the reinforcing effects of both ethanol and nicotine. This study was undertaken to determine whether simultaneous administration of systemic ethanol and microinjection of nicotine into the ventral tegmental area (VTA) would result in exaggerated release of dopamine (DA) in the shell region of nucleus accumbens. METHODS: Microdialysis was applied in awake, freely moving adult male Wistar rats, and DA concentration in the dialysate was measured by HPLC-electrochemical detectors. RESULTS: Systemic administration of ethanol or microinjection of nicotine into VTA resulted in a dose-dependent increase in DA release (extracellular DA concentration). Simultaneous administration of lower doses of nicotine and ethanol resulted in an additive effect on the released DA. This additive effect was not observed with higher doses of nicotine and ethanol. Administration of the nicotinic antagonist mecamylamine into VTA completely blocked ethanol-induced DA release. CONCLUSIONS: These data support the hypothesis that the reinforcing effects of ethanol are at least partially mediated through the nicotinic receptors in the VTA. Furthermore, administration of selective nicotinic antagonists may be of therapeutic potential in reducing the rewarding effects of ethanol. The data also suggest that the combined effects of ethanol and nicotine on the "reward pathway" may be a contributing factor to the high incidence of smoking in alcoholics. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/11923594/Effects_of_combined_systemic_alcohol_and_central_nicotine_administration_into_ventral_tegmental_area_on_dopamine_release_in_the_nucleus_accumbens_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=2002&volume=26&issue=3&spage=394 DB - PRIME DP - Unbound Medicine ER -