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Evaluation of activity of erythrocyte pyrimidine 5'-nucleotidase (P5N) in lead exposed workers: with focus on the effect on hemoglobin.

Abstract

Anemia that accompanies lead poisoning is in part the result of various inhibitory effects of lead on heme biosynthesis. Lead also increases the rate of red blood cell destruction due to the profoundly depressed activities of erythrocyte pyrimidine 5'-nucleotidase (P5N) activities. We studied parameters of the two metabolic pathways in the workers exposed to lead to evaluate P5N in the lead exposed workers and which pathway has an effect on hemoglobin (Hb) level. 29 male workers in the secondary lead smelting as high exposure group, 46 male workers in the manufacturer of inorganic pigment as low exposure group and 56 clerical male workers from another plant as non-exposed group were studied. Activity of P5N, lead concentration in whole blood (PbB), zinc protoporphyrin (ZPP), Hb, and ferritin were determined. In the present study, P5N activity of nucleotide metabolic pathway correlated with Hb after controlling indices of iron deficiency anemia (ferritin) occurring concurrently and heme biosynthetic pathway (ZPP) in the high exposure group while heme biosynthetic pathway did not correlate with Hb after controlling other two variables in exposure groups. These findings suggest that P5N rather than heme biosynthetic pathway has a major effect on Hb level even in workers without manifest hemolytic anemia.

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  • Authors+Show Affiliations

    ,

    Department of Occupational Medicine, University of Ulsan College of Medicine, South Korea.

    , , , , , , , ,

    Source

    Industrial health 40:1 2002 Jan pg 23-7

    MeSH

    5'-Nucleotidase
    Adult
    Analysis of Variance
    Anemia, Hemolytic
    Erythrocytes
    Hemoglobins
    Humans
    Lead
    Lead Poisoning
    Male
    Occupational Diseases
    Occupational Exposure

    Pub Type(s)

    Evaluation Studies
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11926511

    Citation

    Kim, Yangho, et al. "Evaluation of Activity of Erythrocyte Pyrimidine 5'-nucleotidase (P5N) in Lead Exposed Workers: With Focus On the Effect On Hemoglobin." Industrial Health, vol. 40, no. 1, 2002, pp. 23-7.
    Kim Y, Yoo CI, Lee CR, et al. Evaluation of activity of erythrocyte pyrimidine 5'-nucleotidase (P5N) in lead exposed workers: with focus on the effect on hemoglobin. Ind Health. 2002;40(1):23-7.
    Kim, Y., Yoo, C. I., Lee, C. R., Lee, J. H., Lee, H., Kim, S. R., ... Lee, Y. H. (2002). Evaluation of activity of erythrocyte pyrimidine 5'-nucleotidase (P5N) in lead exposed workers: with focus on the effect on hemoglobin. Industrial Health, 40(1), pp. 23-7.
    Kim Y, et al. Evaluation of Activity of Erythrocyte Pyrimidine 5'-nucleotidase (P5N) in Lead Exposed Workers: With Focus On the Effect On Hemoglobin. Ind Health. 2002;40(1):23-7. PubMed PMID: 11926511.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evaluation of activity of erythrocyte pyrimidine 5'-nucleotidase (P5N) in lead exposed workers: with focus on the effect on hemoglobin. AU - Kim,Yangho, AU - Yoo,Cheol-In, AU - Lee,Choong Ryeol, AU - Lee,Ji Ho, AU - Lee,Hun, AU - Kim,Sung-Ryul, AU - Chang,Seoung-Hoon, AU - Lee,Won-Jin, AU - Hwang,Cheon-Hyun, AU - Lee,Young Hwan, PY - 2002/4/3/pubmed PY - 2002/5/25/medline PY - 2002/4/3/entrez SP - 23 EP - 7 JF - Industrial health JO - Ind Health VL - 40 IS - 1 N2 - Anemia that accompanies lead poisoning is in part the result of various inhibitory effects of lead on heme biosynthesis. Lead also increases the rate of red blood cell destruction due to the profoundly depressed activities of erythrocyte pyrimidine 5'-nucleotidase (P5N) activities. We studied parameters of the two metabolic pathways in the workers exposed to lead to evaluate P5N in the lead exposed workers and which pathway has an effect on hemoglobin (Hb) level. 29 male workers in the secondary lead smelting as high exposure group, 46 male workers in the manufacturer of inorganic pigment as low exposure group and 56 clerical male workers from another plant as non-exposed group were studied. Activity of P5N, lead concentration in whole blood (PbB), zinc protoporphyrin (ZPP), Hb, and ferritin were determined. In the present study, P5N activity of nucleotide metabolic pathway correlated with Hb after controlling indices of iron deficiency anemia (ferritin) occurring concurrently and heme biosynthetic pathway (ZPP) in the high exposure group while heme biosynthetic pathway did not correlate with Hb after controlling other two variables in exposure groups. These findings suggest that P5N rather than heme biosynthetic pathway has a major effect on Hb level even in workers without manifest hemolytic anemia. SN - 0019-8366 UR - https://www.unboundmedicine.com/medline/citation/11926511/Evaluation_of_activity_of_erythrocyte_pyrimidine_5'_nucleotidase__P5N__in_lead_exposed_workers:_with_focus_on_the_effect_on_hemoglobin_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/indhealth1963/40.23?from=PubMed DB - PRIME DP - Unbound Medicine ER -