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Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases.
Biol Chem. 2002 Jan; 383(1):101-5.BC

Abstract

Several reports have attributed to green tea chemopreventive and therapeutic properties. Epidemiological studies have linked the regular use of green tea to a reduced incidence of breast and colon carcinomas. Tea contains several antioxidants, including polyphenols of the catechin (green tea) and theaflavin (black tea) groups. Green tea derivatives have been shown to act in vitro and in vivo as anti-inflammatory, anti-viral and anti-tumor drugs. Despite the extensive body of data only few studies have investigated the molecular mechanisms underlying these effects. In this brief review we focus on the inhibitory activity of catechins derived from green tea toward proteases involved in tumor invasion.

Authors+Show Affiliations

Centro di Biotecnologie Avanzate,Genova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11928805

Citation

Benelli, Roberto, et al. "Anti-invasive Effects of Green Tea Polyphenol Epigallocatechin-3-gallate (EGCG), a Natural Inhibitor of Metallo and Serine Proteases." Biological Chemistry, vol. 383, no. 1, 2002, pp. 101-5.
Benelli R, Venè R, Bisacchi D, et al. Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases. Biol Chem. 2002;383(1):101-5.
Benelli, R., Venè, R., Bisacchi, D., Garbisa, S., & Albini, A. (2002). Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases. Biological Chemistry, 383(1), 101-5.
Benelli R, et al. Anti-invasive Effects of Green Tea Polyphenol Epigallocatechin-3-gallate (EGCG), a Natural Inhibitor of Metallo and Serine Proteases. Biol Chem. 2002;383(1):101-5. PubMed PMID: 11928805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases. AU - Benelli,Roberto, AU - Venè,Roberta, AU - Bisacchi,Davide, AU - Garbisa,Spiridione, AU - Albini,Adriana, PY - 2002/4/4/pubmed PY - 2003/2/14/medline PY - 2002/4/4/entrez SP - 101 EP - 5 JF - Biological chemistry JO - Biol Chem VL - 383 IS - 1 N2 - Several reports have attributed to green tea chemopreventive and therapeutic properties. Epidemiological studies have linked the regular use of green tea to a reduced incidence of breast and colon carcinomas. Tea contains several antioxidants, including polyphenols of the catechin (green tea) and theaflavin (black tea) groups. Green tea derivatives have been shown to act in vitro and in vivo as anti-inflammatory, anti-viral and anti-tumor drugs. Despite the extensive body of data only few studies have investigated the molecular mechanisms underlying these effects. In this brief review we focus on the inhibitory activity of catechins derived from green tea toward proteases involved in tumor invasion. SN - 1431-6730 UR - https://www.unboundmedicine.com/medline/citation/11928805/Anti_invasive_effects_of_green_tea_polyphenol_epigallocatechin_3_gallate__EGCG__a_natural_inhibitor_of_metallo_and_serine_proteases_ L2 - https://www.degruyter.com/document/doi/10.1515/BC.2002.010 DB - PRIME DP - Unbound Medicine ER -