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Differentiation of multiple sclerosis from other inflammatory disorders and cerebrovascular disease: value of spinal MR imaging.
Radiology 2002; 223(1):46-56R

Abstract

PURPOSE

To determine the value of magnetic resonance (MR) imaging in the spinal cord to differentiate multiple sclerosis (MS) from other inflammatory disorders and cerebrovascular diseases (together, other neurologic disease [OND]).

MATERIALS AND METHODS

The study population included 66 patients with OND and 25 patients with MS, who were matched for age, sex, and symptom duration or severity. Brain MR imaging included gadolinium-enhanced T1-weighted and dual-echo T2-weighted spin-echo sequences to assess the number, size, and appearance of lesions, contrast enhancement, and compatibility with diagnostic criteria for MS. Spinal cord MR imaging included cardiac-triggered gadolinium-enhanced sagittal T1-weighted spin-echo and dual-echo T2-weighted sequences to assess the general appearance (normal, focal lesion, diffuse abnormality) and number or size of focal lesions. Images obtained in MS and OND patients were compared. Specificity, sensitivity, accuracy, and positive and negative predictive values with MR images were calculated.

RESULTS

Brain images were abnormal in all MS patients and in 65% of OND patients. Abnormal cord images were found in 92% of MS and 6% of OND patients. The combination of brain and spinal cord images increased accuracy of diagnosis compared with use of brain images alone.

CONCLUSION

In contrast to MS, cord lesions are very uncommon in OND. This finding can help differentiate these disorders.

Authors+Show Affiliations

Department of Radiology, MR Center for MS Research, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, the Netherlands. J.Bot@VUMC.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11930047

Citation

Bot, Joost C J., et al. "Differentiation of Multiple Sclerosis From Other Inflammatory Disorders and Cerebrovascular Disease: Value of Spinal MR Imaging." Radiology, vol. 223, no. 1, 2002, pp. 46-56.
Bot JC, Barkhof F, Lycklama à Nijeholt G, et al. Differentiation of multiple sclerosis from other inflammatory disorders and cerebrovascular disease: value of spinal MR imaging. Radiology. 2002;223(1):46-56.
Bot, J. C., Barkhof, F., Lycklama à Nijeholt, G., van Schaardenburg, D., Voskuyl, A. E., Ader, H. J., ... Castelijns, J. A. (2002). Differentiation of multiple sclerosis from other inflammatory disorders and cerebrovascular disease: value of spinal MR imaging. Radiology, 223(1), pp. 46-56.
Bot JC, et al. Differentiation of Multiple Sclerosis From Other Inflammatory Disorders and Cerebrovascular Disease: Value of Spinal MR Imaging. Radiology. 2002;223(1):46-56. PubMed PMID: 11930047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differentiation of multiple sclerosis from other inflammatory disorders and cerebrovascular disease: value of spinal MR imaging. AU - Bot,Joost C J, AU - Barkhof,Frederik, AU - Lycklama à Nijeholt,Geert, AU - van Schaardenburg,Dirkjan, AU - Voskuyl,Alexandre E, AU - Ader,Herman J, AU - Pijnenburg,Jolanda A L, AU - Polman,Chris H, AU - Uitdehaag,Bernard M J, AU - Vermeulen,Erik G J, AU - Castelijns,Jonas A, PY - 2002/4/4/pubmed PY - 2002/6/5/medline PY - 2002/4/4/entrez SP - 46 EP - 56 JF - Radiology JO - Radiology VL - 223 IS - 1 N2 - PURPOSE: To determine the value of magnetic resonance (MR) imaging in the spinal cord to differentiate multiple sclerosis (MS) from other inflammatory disorders and cerebrovascular diseases (together, other neurologic disease [OND]). MATERIALS AND METHODS: The study population included 66 patients with OND and 25 patients with MS, who were matched for age, sex, and symptom duration or severity. Brain MR imaging included gadolinium-enhanced T1-weighted and dual-echo T2-weighted spin-echo sequences to assess the number, size, and appearance of lesions, contrast enhancement, and compatibility with diagnostic criteria for MS. Spinal cord MR imaging included cardiac-triggered gadolinium-enhanced sagittal T1-weighted spin-echo and dual-echo T2-weighted sequences to assess the general appearance (normal, focal lesion, diffuse abnormality) and number or size of focal lesions. Images obtained in MS and OND patients were compared. Specificity, sensitivity, accuracy, and positive and negative predictive values with MR images were calculated. RESULTS: Brain images were abnormal in all MS patients and in 65% of OND patients. Abnormal cord images were found in 92% of MS and 6% of OND patients. The combination of brain and spinal cord images increased accuracy of diagnosis compared with use of brain images alone. CONCLUSION: In contrast to MS, cord lesions are very uncommon in OND. This finding can help differentiate these disorders. SN - 0033-8419 UR - https://www.unboundmedicine.com/medline/citation/11930047/Differentiation_of_multiple_sclerosis_from_other_inflammatory_disorders_and_cerebrovascular_disease:_value_of_spinal_MR_imaging_ L2 - http://pubs.rsna.org/doi/10.1148/radiol.2231010707?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -