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[Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain].
Sheng Li Xue Bao. 2002 Feb 25; 54(1):60-4.SL

Abstract

In formalin pain model, the effect of propofol on Fos expression in the spinal cord was examined by means of c -fos oncogene immunohistochemistry and NADPH-d histochemistry. Fos-like immunoreactive (FLI) neurons were mainly found in the ipsilateral dorsal horn after injection of formalin, some of which were FLI/NOS double-labeled neurons. Most of the FLI or FLI/NOS double-labeled neurons were observed in the medial part of lamina and the outer lamina . Before or after injection of formain, i.p. injection of propofol significantly decreased the number of FLI and FLI/NOS double-labeled neurons in all laminae (P<0.05 or P<0.01). By single i.p. injection of propofol or normal saline, few FLI neurons were found in the spinal cord. The results suggest that the antinociceptive function of propofol is possibly involved in the depression of the NOS neurons in the spinal cord.

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Authors+Show Affiliations

Yan M
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006; yjy3001@263.net
Zhang LC
No affiliation info available
Dai TJ
No affiliation info available
Zheng YM
No affiliation info available
Duan SM
No affiliation info available

MeSH

AnimalsFemaleFormaldehydeMaleNeuronsNitric Oxide SynthasePainPropofolProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleySpinal Cord

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11930243

Citation

Yan, Ming, et al. "[Propofol Depresses C -fos Expression of NOS Neurons in the Spinal Cord of Rats With Inflammatory Pain]." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 54, no. 1, 2002, pp. 60-4.
Yan M, Zhang LC, Dai TJ, et al. [Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain]. Sheng Li Xue Bao. 2002;54(1):60-4.
Yan, M., Zhang, L. C., Dai, T. J., Zheng, Y. M., & Duan, S. M. (2002). [Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain]. Sheng Li Xue Bao : [Acta Physiologica Sinica], 54(1), 60-4.
Yan M, et al. [Propofol Depresses C -fos Expression of NOS Neurons in the Spinal Cord of Rats With Inflammatory Pain]. Sheng Li Xue Bao. 2002 Feb 25;54(1):60-4. PubMed PMID: 11930243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain]. AU - Yan,Ming, AU - Zhang,Li-Cai, AU - Dai,Ti-Jun, AU - Zheng,Yin-Ming, AU - Duan,Shi-Ming, PY - 2002/4/4/pubmed PY - 2003/2/4/medline PY - 2002/4/4/entrez SP - 60 EP - 4 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 54 IS - 1 N2 - In formalin pain model, the effect of propofol on Fos expression in the spinal cord was examined by means of c -fos oncogene immunohistochemistry and NADPH-d histochemistry. Fos-like immunoreactive (FLI) neurons were mainly found in the ipsilateral dorsal horn after injection of formalin, some of which were FLI/NOS double-labeled neurons. Most of the FLI or FLI/NOS double-labeled neurons were observed in the medial part of lamina and the outer lamina . Before or after injection of formain, i.p. injection of propofol significantly decreased the number of FLI and FLI/NOS double-labeled neurons in all laminae (P<0.05 or P<0.01). By single i.p. injection of propofol or normal saline, few FLI neurons were found in the spinal cord. The results suggest that the antinociceptive function of propofol is possibly involved in the depression of the NOS neurons in the spinal cord. SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/11930243/[Propofol_depresses_c__fos_expression_of_NOS_neurons_in_the_spinal_cord_of_rats_with_inflammatory_pain]_ L2 - http://www.actaps.com.cn/paper/200201/article/2002-1-12.pdf DB - PRIME DP - Unbound Medicine ER -