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Understanding Parkinson's disease: detection and early disease management.
Lippincotts Prim Care Pract. 2000 Nov-Dec; 4(6):595-607.LP

Abstract

Parkinson's disease (PD) is a common, debilitating, neurodegenerative disorder characterized by neuronal loss within the basal ganglia and insufficient levels of the neurotransmitter dopamine. Symptoms include resting tremor, rigidity, bradykinesia (slowness of voluntary movement), and postural disturbances. Exact cause is unknown, but theories surrounding environmental or endogenous toxicities have been suggested. Differential diagnoses include genetic and other neurologic disorders that may share symptoms similar to those seen in PD. Clinical progression has been categorized into three phases of the disease: early, nonfluctuating, and fluctuating. Medications generally offer good symptom relief during the early and nonfluctuating phases of the disease. Classifications of anti-PD medications include anticholinergics, dopamine agonists, amantadine, MAO-B inhibitors, levodopa-carbidopa, and Catechol-o-methyl transferase inhibitors. Surgical intervention may be an option for select patients whose conditions are not well controlled though medical management strategies. Primary care providers often can manage patients in the early stage of PD, but later stages require expert neurologic management. Patient/family education and anticipatory guidance is imperative.

Authors+Show Affiliations

University of California, San Francisco School of Nursing, Department of Physiological Nursing, Gerontological Nurse Practitioner Program, 2 Kirkham Street, Box 0610, San Francisco, CA 94143-0610, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11933373

Citation

Mackin, L A.. "Understanding Parkinson's Disease: Detection and Early Disease Management." Lippincott's Primary Care Practice, vol. 4, no. 6, 2000, pp. 595-607.
Mackin LA. Understanding Parkinson's disease: detection and early disease management. Lippincotts Prim Care Pract. 2000;4(6):595-607.
Mackin, L. A. (2000). Understanding Parkinson's disease: detection and early disease management. Lippincott's Primary Care Practice, 4(6), 595-607.
Mackin LA. Understanding Parkinson's Disease: Detection and Early Disease Management. Lippincotts Prim Care Pract. 2000 Nov-Dec;4(6):595-607. PubMed PMID: 11933373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Understanding Parkinson's disease: detection and early disease management. A1 - Mackin,L A, PY - 2002/4/6/pubmed PY - 2002/10/9/medline PY - 2002/4/6/entrez SP - 595 EP - 607 JF - Lippincott's primary care practice JO - Lippincotts Prim Care Pract VL - 4 IS - 6 N2 - Parkinson's disease (PD) is a common, debilitating, neurodegenerative disorder characterized by neuronal loss within the basal ganglia and insufficient levels of the neurotransmitter dopamine. Symptoms include resting tremor, rigidity, bradykinesia (slowness of voluntary movement), and postural disturbances. Exact cause is unknown, but theories surrounding environmental or endogenous toxicities have been suggested. Differential diagnoses include genetic and other neurologic disorders that may share symptoms similar to those seen in PD. Clinical progression has been categorized into three phases of the disease: early, nonfluctuating, and fluctuating. Medications generally offer good symptom relief during the early and nonfluctuating phases of the disease. Classifications of anti-PD medications include anticholinergics, dopamine agonists, amantadine, MAO-B inhibitors, levodopa-carbidopa, and Catechol-o-methyl transferase inhibitors. Surgical intervention may be an option for select patients whose conditions are not well controlled though medical management strategies. Primary care providers often can manage patients in the early stage of PD, but later stages require expert neurologic management. Patient/family education and anticipatory guidance is imperative. SN - 1088-5471 UR - https://www.unboundmedicine.com/medline/citation/11933373/Understanding_Parkinson's_disease:_detection_and_early_disease_management_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11933373.ui DB - PRIME DP - Unbound Medicine ER -