Tags

Type your tag names separated by a space and hit enter

A histological comparison of acute inflammatory responses with a hydrofibre or tulle gauze dressing.
J Wound Care. 2002 Mar; 11(3):113-7.JW

Abstract

OBJECTIVE

This study analysed the physical properties of Aquacel hydrofibre dressing in rat partial-thickness wounds, focusing on the acute inflammatory infiltrate of granulocytes and macrophages in the wound and the dressing.

METHOD

Partial-thickness wounds (2 x 2 cm) were made on the back of 60 anaesthetised male Wistar rats and covered with Aquacel (n = 30) and tulle gauze (n = 30). The rats were killed on postoperative days one, two, three, four, seven and 10 (10 animals per day and five per dressing). Re-epithelialisation and Polymorphonuclear (PMN), fibronectin and macrophage activity were then analysed.

RESULTS

PMN leucocytes (granulocytes) were captured in the dressing and remained active there, resulting in a reduced number in the wounds when compared with tulle gauze. A fibrin layer formed between the dressing and the wound, creating a physical barrier. Macrophages infiltrated the wound bed but could not be detected in the dressing. Little inflammation was observed in the wound bed and the macrophages operated primarily in the repair mode. Active PMNs in the dressing provided an appropriate antimicrobial environment. Tulle materials became embedded in wounds and were associated with a more disturbed pattern of epithelial outgrowth. Aquacel stayed 'on top' of wounds, with only minimal incorporation into the superficial epidermis.

CONCLUSION

The observations of the physical properties of different materials and their histological consequences correlate well with published clinical results, particularly in relation to the speed of re-epithelialisation and the level of scarring.

Authors+Show Affiliations

Burns Research Institute, Beverwijk, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11933728

Citation

Hoekstra, M J., et al. "A Histological Comparison of Acute Inflammatory Responses With a Hydrofibre or Tulle Gauze Dressing." Journal of Wound Care, vol. 11, no. 3, 2002, pp. 113-7.
Hoekstra MJ, Hermans MH, Richters CD, et al. A histological comparison of acute inflammatory responses with a hydrofibre or tulle gauze dressing. J Wound Care. 2002;11(3):113-7.
Hoekstra, M. J., Hermans, M. H., Richters, C. D., & Dutrieux, R. P. (2002). A histological comparison of acute inflammatory responses with a hydrofibre or tulle gauze dressing. Journal of Wound Care, 11(3), 113-7.
Hoekstra MJ, et al. A Histological Comparison of Acute Inflammatory Responses With a Hydrofibre or Tulle Gauze Dressing. J Wound Care. 2002;11(3):113-7. PubMed PMID: 11933728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A histological comparison of acute inflammatory responses with a hydrofibre or tulle gauze dressing. AU - Hoekstra,M J, AU - Hermans,M H E, AU - Richters,C D, AU - Dutrieux,R P, PY - 2002/4/6/pubmed PY - 2002/7/4/medline PY - 2002/4/6/entrez SP - 113 EP - 7 JF - Journal of wound care JO - J Wound Care VL - 11 IS - 3 N2 - OBJECTIVE: This study analysed the physical properties of Aquacel hydrofibre dressing in rat partial-thickness wounds, focusing on the acute inflammatory infiltrate of granulocytes and macrophages in the wound and the dressing. METHOD: Partial-thickness wounds (2 x 2 cm) were made on the back of 60 anaesthetised male Wistar rats and covered with Aquacel (n = 30) and tulle gauze (n = 30). The rats were killed on postoperative days one, two, three, four, seven and 10 (10 animals per day and five per dressing). Re-epithelialisation and Polymorphonuclear (PMN), fibronectin and macrophage activity were then analysed. RESULTS: PMN leucocytes (granulocytes) were captured in the dressing and remained active there, resulting in a reduced number in the wounds when compared with tulle gauze. A fibrin layer formed between the dressing and the wound, creating a physical barrier. Macrophages infiltrated the wound bed but could not be detected in the dressing. Little inflammation was observed in the wound bed and the macrophages operated primarily in the repair mode. Active PMNs in the dressing provided an appropriate antimicrobial environment. Tulle materials became embedded in wounds and were associated with a more disturbed pattern of epithelial outgrowth. Aquacel stayed 'on top' of wounds, with only minimal incorporation into the superficial epidermis. CONCLUSION: The observations of the physical properties of different materials and their histological consequences correlate well with published clinical results, particularly in relation to the speed of re-epithelialisation and the level of scarring. SN - 0969-0700 UR - https://www.unboundmedicine.com/medline/citation/11933728/A_histological_comparison_of_acute_inflammatory_responses_with_a_hydrofibre_or_tulle_gauze_dressing_ L2 - http://www.magonlinelibrary.com/doi/full/10.12968/jowc.2002.11.3.26384?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -