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Modulatory effect of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assay.
J Environ Pathol Toxicol Oncol. 2002; 21(1):45-56.JE

Abstract

We determined the antimutagenicity of phenolic fractions of Terminalia arjuna (soluble and insoluble in chloroform) against two direct-acting mutagens, 4-nitro-o-phenylenediamine (NPD) and sodium azide, and against the S9-dependent mutagen 2-aminofluorene (2AF), in TA98 and TA100 tester strains of Salmonella typhimurium. We found that the phenolic fractions of T. arjuna inhibited revertants induced by the S9-dependent mutagen more remarkably than the direct-acting mutagens. Furthermore, the phenolic fractions showed maximum inhibition of 98% and 101.55%, respectively, in the pre-incubation mode of treatment against the mutations induced by 2AF. Overall, the fractions inhibited the revertants induced by S9-dependent mutagens more effectively than those induced by direct-acting mutagens. The percentage of inhibition was higher in the pre-incubation than with direct acting mutagens. The fraction insoluble in chloroform showed more inhibition than the soluble one, which corresponds to a higher polyphenol content in the insoluble fraction than in the soluble extract.

Authors+Show Affiliations

Kaur K
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, India. kamal_rajput@usa.net
Arora S
No affiliation info available
Kumar S
No affiliation info available
Nagpal A
No affiliation info available

MeSH

CarcinogensDNA DamageDose-Response Relationship, DrugEnzyme InhibitorsPhenolsPhenylenediaminesPlant ExtractsProtective AgentsSalmonella typhimuriumSodium AzideSolubilitySolventsTerminalia

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11934012

Citation

Kaur, Kamaljit, et al. "Modulatory Effect of Phenolic Fractions of Terminalia Arjuna On the Mutagenicity in Ames Assay." Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, vol. 21, no. 1, 2002, pp. 45-56.
Kaur K, Arora S, Kumar S, et al. Modulatory effect of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assay. J Environ Pathol Toxicol Oncol. 2002;21(1):45-56.
Kaur, K., Arora, S., Kumar, S., & Nagpal, A. (2002). Modulatory effect of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assay. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, 21(1), 45-56.
Kaur K, et al. Modulatory Effect of Phenolic Fractions of Terminalia Arjuna On the Mutagenicity in Ames Assay. J Environ Pathol Toxicol Oncol. 2002;21(1):45-56. PubMed PMID: 11934012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulatory effect of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assay. AU - Kaur,Kamaljit, AU - Arora,Saroj, AU - Kumar,Subodh, AU - Nagpal,Avinash, PY - 2002/4/6/pubmed PY - 2002/4/17/medline PY - 2002/4/6/entrez SP - 45 EP - 56 JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer JO - J Environ Pathol Toxicol Oncol VL - 21 IS - 1 N2 - We determined the antimutagenicity of phenolic fractions of Terminalia arjuna (soluble and insoluble in chloroform) against two direct-acting mutagens, 4-nitro-o-phenylenediamine (NPD) and sodium azide, and against the S9-dependent mutagen 2-aminofluorene (2AF), in TA98 and TA100 tester strains of Salmonella typhimurium. We found that the phenolic fractions of T. arjuna inhibited revertants induced by the S9-dependent mutagen more remarkably than the direct-acting mutagens. Furthermore, the phenolic fractions showed maximum inhibition of 98% and 101.55%, respectively, in the pre-incubation mode of treatment against the mutations induced by 2AF. Overall, the fractions inhibited the revertants induced by S9-dependent mutagens more effectively than those induced by direct-acting mutagens. The percentage of inhibition was higher in the pre-incubation than with direct acting mutagens. The fraction insoluble in chloroform showed more inhibition than the soluble one, which corresponds to a higher polyphenol content in the insoluble fraction than in the soluble extract. SN - 0731-8898 UR - https://www.unboundmedicine.com/medline/citation/11934012/Modulatory_effect_of_phenolic_fractions_of_Terminalia_arjuna_on_the_mutagenicity_in_Ames_assay_ DB - PRIME DP - Unbound Medicine ER -