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Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly.
Acta Neuropathol 2002; 103(5):481-7AN

Abstract

The relative importance of vascular and Alzheimer's disease (AD) lesions, their interaction in the development of cognitive impairment and the very existence of mixed dementia induced by the potentiation of both mechanisms remain controversial. The aim of this study was to assess whether the patients with infarcts and lacunes have fewer plaques and tangles than those without vascular lesions, for similar severity of clinical dementia. We performed a prospective clinicopathological study in elderly patients of a long-stay care unit. The severity of clinical dementia was assessed by psychometry performed according to standardized methods less than 6 months before death. A volumetric study of cerebral vascular lesions was performed at post-mortem study of the brain. The density of neuritic plaques (SP), Amyloid beta focal deposits (A beta FD), and neurofibrillary tangles (NFT) in the temporal and frontal isocortex was quantified. According to DSM III criteria, 28 of the 33 patients for whom autopsies were performed had dementia. Twenty-four of the included patients had degenerative or vascular lesions, or both. The volume of infarcts and lacunes was significantly correlated with the severity of cognitive impairment. The density of SP, A beta FD and NFT in the temporal and frontal isocortex was significantly lower when vascular lesions were present. For similar clinical severity of dementia, there were fewer AD lesions in patients with vascular lesions than in those without vascular lesions.

Authors+Show Affiliations

Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Salpêtrière, INSERM U 106 and 360, Association Claude Bernard, Pierre et Marie Curie University, 47 Bd de l'Hôpital, 75013 Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11935264

Citation

Zekry, Dina, et al. "Degenerative and Vascular Lesions of the Brain Have Synergistic Effects in Dementia of the Elderly." Acta Neuropathologica, vol. 103, no. 5, 2002, pp. 481-7.
Zekry D, Duyckaerts C, Moulias R, et al. Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly. Acta Neuropathol. 2002;103(5):481-7.
Zekry, D., Duyckaerts, C., Moulias, R., Belmin, J., Geoffre, C., Herrmann, F., & Hauw, J. J. (2002). Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly. Acta Neuropathologica, 103(5), pp. 481-7.
Zekry D, et al. Degenerative and Vascular Lesions of the Brain Have Synergistic Effects in Dementia of the Elderly. Acta Neuropathol. 2002;103(5):481-7. PubMed PMID: 11935264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly. AU - Zekry,Dina, AU - Duyckaerts,Charles, AU - Moulias,Robert, AU - Belmin,Joël, AU - Geoffre,Caroline, AU - Herrmann,François, AU - Hauw,Jean-Jacques, Y1 - 2002/02/06/ PY - 2001/06/09/received PY - 2002/4/6/pubmed PY - 2002/6/22/medline PY - 2002/4/6/entrez SP - 481 EP - 7 JF - Acta neuropathologica JO - Acta Neuropathol. VL - 103 IS - 5 N2 - The relative importance of vascular and Alzheimer's disease (AD) lesions, their interaction in the development of cognitive impairment and the very existence of mixed dementia induced by the potentiation of both mechanisms remain controversial. The aim of this study was to assess whether the patients with infarcts and lacunes have fewer plaques and tangles than those without vascular lesions, for similar severity of clinical dementia. We performed a prospective clinicopathological study in elderly patients of a long-stay care unit. The severity of clinical dementia was assessed by psychometry performed according to standardized methods less than 6 months before death. A volumetric study of cerebral vascular lesions was performed at post-mortem study of the brain. The density of neuritic plaques (SP), Amyloid beta focal deposits (A beta FD), and neurofibrillary tangles (NFT) in the temporal and frontal isocortex was quantified. According to DSM III criteria, 28 of the 33 patients for whom autopsies were performed had dementia. Twenty-four of the included patients had degenerative or vascular lesions, or both. The volume of infarcts and lacunes was significantly correlated with the severity of cognitive impairment. The density of SP, A beta FD and NFT in the temporal and frontal isocortex was significantly lower when vascular lesions were present. For similar clinical severity of dementia, there were fewer AD lesions in patients with vascular lesions than in those without vascular lesions. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/11935264/Degenerative_and_vascular_lesions_of_the_brain_have_synergistic_effects_in_dementia_of_the_elderly_ L2 - https://dx.doi.org/10.1007/s00401-001-0493-5 DB - PRIME DP - Unbound Medicine ER -