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Neuritic pathology is lacking in the entorhinal cortex, subiculum and hippocampus in middle-aged adults with schizophrenia, bipolar disorder or unipolar depression.
Acta Neuropathol. 2002 May; 103(5):488-94.AN

Abstract

Earlier reports have provided conflicting results regarding the association between Alzheimer's disease (AD) and mental disorders. Using a well-characterized postmortem series of 40 middle-aged human brains, we have performed quantitative analysis of neurofibrillary tangles and senile plaques in the entorhinal cortex, subiculum and rostral hippocampus in 9 subjects with schizophrenia, 8 with bipolar disorder, 12 with depression, and 11 age- and sex-matched controls. No significant differences were found among the four groups. Our study indicates that the Alzheimer-type changes, which might be related to the likelihood of AD development later in life, are not increased in middle-aged subjects with mental illness. The result also supports the more recent reports that have demonstrated no increased incidence of AD in mentally ill patients.

Authors+Show Affiliations

Section of Neuropathology, Clinical Brain Disorders Branch, Building 36, Room 3A24, 36 Convent Drive, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-4091, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11935265

Citation

Damadzic, Ruslan, et al. "Neuritic Pathology Is Lacking in the Entorhinal Cortex, Subiculum and Hippocampus in Middle-aged Adults With Schizophrenia, Bipolar Disorder or Unipolar Depression." Acta Neuropathologica, vol. 103, no. 5, 2002, pp. 488-94.
Damadzic R, Shuangshoti S, Giblen G, et al. Neuritic pathology is lacking in the entorhinal cortex, subiculum and hippocampus in middle-aged adults with schizophrenia, bipolar disorder or unipolar depression. Acta Neuropathol. 2002;103(5):488-94.
Damadzic, R., Shuangshoti, S., Giblen, G., & Herman, M. M. (2002). Neuritic pathology is lacking in the entorhinal cortex, subiculum and hippocampus in middle-aged adults with schizophrenia, bipolar disorder or unipolar depression. Acta Neuropathologica, 103(5), 488-94.
Damadzic R, et al. Neuritic Pathology Is Lacking in the Entorhinal Cortex, Subiculum and Hippocampus in Middle-aged Adults With Schizophrenia, Bipolar Disorder or Unipolar Depression. Acta Neuropathol. 2002;103(5):488-94. PubMed PMID: 11935265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuritic pathology is lacking in the entorhinal cortex, subiculum and hippocampus in middle-aged adults with schizophrenia, bipolar disorder or unipolar depression. AU - Damadzic,Ruslan, AU - Shuangshoti,Shanop, AU - Giblen,Georgeta, AU - Herman,Mary M, Y1 - 2002/01/31/ PY - 2001/07/30/received PY - 2002/4/6/pubmed PY - 2002/6/22/medline PY - 2002/4/6/entrez SP - 488 EP - 94 JF - Acta neuropathologica JO - Acta Neuropathol. VL - 103 IS - 5 N2 - Earlier reports have provided conflicting results regarding the association between Alzheimer's disease (AD) and mental disorders. Using a well-characterized postmortem series of 40 middle-aged human brains, we have performed quantitative analysis of neurofibrillary tangles and senile plaques in the entorhinal cortex, subiculum and rostral hippocampus in 9 subjects with schizophrenia, 8 with bipolar disorder, 12 with depression, and 11 age- and sex-matched controls. No significant differences were found among the four groups. Our study indicates that the Alzheimer-type changes, which might be related to the likelihood of AD development later in life, are not increased in middle-aged subjects with mental illness. The result also supports the more recent reports that have demonstrated no increased incidence of AD in mentally ill patients. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/11935265/Neuritic_pathology_is_lacking_in_the_entorhinal_cortex_subiculum_and_hippocampus_in_middle_aged_adults_with_schizophrenia_bipolar_disorder_or_unipolar_depression_ L2 - https://dx.doi.org/10.1007/s00401-001-0496-2 DB - PRIME DP - Unbound Medicine ER -