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Uveitis in juvenile arthritis.
Ocul Immunol Inflamm. 2001 Dec; 9(4):243-51.OI

Abstract

PURPOSE

To evaluate the clinical features of and determine the risk factors for uveitis in patients with juvenile arthritis.

METHODS

The prevalence and clinical characteristics of uveitis were studied retrospectively in 90 children diagnosed with arthritis. Patients with uveitis were compared with those who did not have eye involvement.

RESULTS

Uveitis was diagnosed in 11 patients (12.2%). Of these, seven (63.6%) had oligoarticular, two (36.4%) had polyarticular, and one (9.1%) had systemic-onset juvenile rheumatoid arthritis (JRA). One patient (9.1%) was diagnosed with enthesitis-related arthritis (ERA) (9.1%). The prevalence of uveitis was significantly higher in patients with oligoarticular JRA. The mean age at onset of arthritis in the uveitis patients was 4.39 years, which was significantly lower than in the non-uveitis group. There was no gender difference in the risk of developing uveitis. Antinuclear antibodies (ANA) was positive in seven (63.6%) of the 11 uveitis patients, confirming ANA as a significant determinant for uveitis in juvenile arthritis. Rheumatoid factor was not found to be a risk factor. One (9.1%) of the 11 patients developed serious sight-threatening complications during the follow-up period.

CONCLUSION

This study confirmed that oligoarticular onset, ANA positivity, and young age are risk factors for developing uveitis in patients with juvenile arthritis. Gender was not found to be a determining factor. Prompt treatment of uveitis effectively decreased the prevalence of visual impairment.

Authors+Show Affiliations

Department of Ophthalmology, School of Medicine, Dokuz Eylül University, Urla Berk Sitesi 143, Urla/Izmir, Turkey. tulin.berk@deu.edu.trNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11935434

Citation

Berk, A T., et al. "Uveitis in Juvenile Arthritis." Ocular Immunology and Inflammation, vol. 9, no. 4, 2001, pp. 243-51.
Berk AT, Koçak N, Unsal E. Uveitis in juvenile arthritis. Ocul Immunol Inflamm. 2001;9(4):243-51.
Berk, A. T., Koçak, N., & Unsal, E. (2001). Uveitis in juvenile arthritis. Ocular Immunology and Inflammation, 9(4), 243-51.
Berk AT, Koçak N, Unsal E. Uveitis in Juvenile Arthritis. Ocul Immunol Inflamm. 2001;9(4):243-51. PubMed PMID: 11935434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uveitis in juvenile arthritis. AU - Berk,A T, AU - Koçak,N, AU - Unsal,E, PY - 2002/4/6/pubmed PY - 2002/6/4/medline PY - 2002/4/6/entrez SP - 243 EP - 51 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 9 IS - 4 N2 - PURPOSE: To evaluate the clinical features of and determine the risk factors for uveitis in patients with juvenile arthritis. METHODS: The prevalence and clinical characteristics of uveitis were studied retrospectively in 90 children diagnosed with arthritis. Patients with uveitis were compared with those who did not have eye involvement. RESULTS: Uveitis was diagnosed in 11 patients (12.2%). Of these, seven (63.6%) had oligoarticular, two (36.4%) had polyarticular, and one (9.1%) had systemic-onset juvenile rheumatoid arthritis (JRA). One patient (9.1%) was diagnosed with enthesitis-related arthritis (ERA) (9.1%). The prevalence of uveitis was significantly higher in patients with oligoarticular JRA. The mean age at onset of arthritis in the uveitis patients was 4.39 years, which was significantly lower than in the non-uveitis group. There was no gender difference in the risk of developing uveitis. Antinuclear antibodies (ANA) was positive in seven (63.6%) of the 11 uveitis patients, confirming ANA as a significant determinant for uveitis in juvenile arthritis. Rheumatoid factor was not found to be a risk factor. One (9.1%) of the 11 patients developed serious sight-threatening complications during the follow-up period. CONCLUSION: This study confirmed that oligoarticular onset, ANA positivity, and young age are risk factors for developing uveitis in patients with juvenile arthritis. Gender was not found to be a determining factor. Prompt treatment of uveitis effectively decreased the prevalence of visual impairment. SN - 0927-3948 UR - https://www.unboundmedicine.com/medline/citation/11935434/Uveitis_in_juvenile_arthritis_ L2 - https://www.tandfonline.com/doi/full/10.1076/ocii.9.4.243.3959 DB - PRIME DP - Unbound Medicine ER -