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Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders.
Fertil Steril. 2002 Apr; 77(4):776-80.FS

Abstract

OBJECTIVE

To examine the use of the aromatase inhibitor letrozole with FSH for ovarian stimulation in poor responders undergoing ovarian superovulation and IUI.

DESIGN

Observational cohort study as a prospective clinical trial in patients with unexplained infertility and a low response to ovarian stimulation with FSH.

SETTING

Two tertiary referral infertility clinics associated with the Reproductive Sciences Division, University of Toronto.

PATIENT(S)

Twelve patients with unexplained infertility undergoing IUI who received FSH alone in 25 prior cycles with poor response (less than three dominant follicles).

INTERVENTION(S)

Patients were offered letrozole, 2.5 mg/day from day 3-7 of the menstrual cycle with FSH (50-225 IU/day) starting on day 5-7. hCG (10,000 IU) was given when two leading follicles were >/=2 cm followed by IUI.

MAIN OUTCOME MEASURE(S)

Number of mature follicles (>1.8 cm), FSH dose, endometrial thickness, and pregnancy rate.

RESULT(S)

Improved response to FSH stimulation with letrozole co-treatment was evidenced by the significantly lower FSH dose associated with significantly higher number of mature follicles. During letrozole plus FSH stimulation cycles, clinical pregnancy was achieved in three cycles (21%).

CONCLUSION(S)

In this preliminary report, we demonstrate a potential benefit of aromatase inhibition for improving ovarian response to FSH in poor responders.

Authors+Show Affiliations

Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Samuel Lunenfeld Research Institute and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11937133

Citation

Mitwally, Mohamed Farouk M., and Robert F. Casper. "Aromatase Inhibition Improves Ovarian Response to Follicle-stimulating Hormone in Poor Responders." Fertility and Sterility, vol. 77, no. 4, 2002, pp. 776-80.
Mitwally MF, Casper RF. Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders. Fertil Steril. 2002;77(4):776-80.
Mitwally, M. F., & Casper, R. F. (2002). Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders. Fertility and Sterility, 77(4), 776-80.
Mitwally MF, Casper RF. Aromatase Inhibition Improves Ovarian Response to Follicle-stimulating Hormone in Poor Responders. Fertil Steril. 2002;77(4):776-80. PubMed PMID: 11937133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders. AU - Mitwally,Mohamed Farouk M, AU - Casper,Robert F, PY - 2002/4/9/pubmed PY - 2003/1/31/medline PY - 2002/4/9/entrez SP - 776 EP - 80 JF - Fertility and sterility JO - Fertil. Steril. VL - 77 IS - 4 N2 - OBJECTIVE: To examine the use of the aromatase inhibitor letrozole with FSH for ovarian stimulation in poor responders undergoing ovarian superovulation and IUI. DESIGN: Observational cohort study as a prospective clinical trial in patients with unexplained infertility and a low response to ovarian stimulation with FSH. SETTING: Two tertiary referral infertility clinics associated with the Reproductive Sciences Division, University of Toronto. PATIENT(S): Twelve patients with unexplained infertility undergoing IUI who received FSH alone in 25 prior cycles with poor response (less than three dominant follicles). INTERVENTION(S): Patients were offered letrozole, 2.5 mg/day from day 3-7 of the menstrual cycle with FSH (50-225 IU/day) starting on day 5-7. hCG (10,000 IU) was given when two leading follicles were >/=2 cm followed by IUI. MAIN OUTCOME MEASURE(S): Number of mature follicles (>1.8 cm), FSH dose, endometrial thickness, and pregnancy rate. RESULT(S): Improved response to FSH stimulation with letrozole co-treatment was evidenced by the significantly lower FSH dose associated with significantly higher number of mature follicles. During letrozole plus FSH stimulation cycles, clinical pregnancy was achieved in three cycles (21%). CONCLUSION(S): In this preliminary report, we demonstrate a potential benefit of aromatase inhibition for improving ovarian response to FSH in poor responders. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/11937133/Aromatase_inhibition_improves_ovarian_response_to_follicle_stimulating_hormone_in_poor_responders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015028201032800 DB - PRIME DP - Unbound Medicine ER -