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Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection.
J Immunol. 2002 Apr 15; 168(8):3777-85.JI

Abstract

In this report, we demonstrate that CD28(-/-) mice are severely impaired in the initial expansion of D(b)/NP366-374-specific CD8 T cells in response to influenza virus infection, whereas 4-1BB ligand (4-1BBL)(-/-) mice show no defect in primary T cell expansion to influenza virus. In contrast, 4-1BBL(-/-) mice show a decrease in D(b)/NP366-374-specific T cells late in the primary response. Upon secondary challenge with influenza virus, 4-1BBL(-/-) mice show a decrease in the number of D(b)/NP366-374-specific T cells compared to wild-type mice such that the level of the CD8 T cell expansion during the in vivo secondary response is reduced to the level of a primary response, with concomitant reduction of CTL effector function. In contrast, Ab responses, as well as secondary CD4 T cell responses, to influenza are unaffected by 4-1BBL deficiency. Thus, CD28 is critical for initial T cell expansion, whereas 4-1BB/4-1BBL signaling affects T cell numbers much later in the response and is essential for the survival and/or responsiveness of the memory CD8 T cell pool.

Authors+Show Affiliations

Department of Immunology, University of Toronto, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11937529

Citation

Bertram, Edward M., et al. "Temporal Segregation of 4-1BB Versus CD28-mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection." Journal of Immunology (Baltimore, Md. : 1950), vol. 168, no. 8, 2002, pp. 3777-85.
Bertram EM, Lau P, Watts TH. Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. J Immunol. 2002;168(8):3777-85.
Bertram, E. M., Lau, P., & Watts, T. H. (2002). Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. Journal of Immunology (Baltimore, Md. : 1950), 168(8), 3777-85.
Bertram EM, Lau P, Watts TH. Temporal Segregation of 4-1BB Versus CD28-mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection. J Immunol. 2002 Apr 15;168(8):3777-85. PubMed PMID: 11937529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. AU - Bertram,Edward M, AU - Lau,Peggy, AU - Watts,Tania H, PY - 2002/4/9/pubmed PY - 2002/5/25/medline PY - 2002/4/9/entrez SP - 3777 EP - 85 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J. Immunol. VL - 168 IS - 8 N2 - In this report, we demonstrate that CD28(-/-) mice are severely impaired in the initial expansion of D(b)/NP366-374-specific CD8 T cells in response to influenza virus infection, whereas 4-1BB ligand (4-1BBL)(-/-) mice show no defect in primary T cell expansion to influenza virus. In contrast, 4-1BBL(-/-) mice show a decrease in D(b)/NP366-374-specific T cells late in the primary response. Upon secondary challenge with influenza virus, 4-1BBL(-/-) mice show a decrease in the number of D(b)/NP366-374-specific T cells compared to wild-type mice such that the level of the CD8 T cell expansion during the in vivo secondary response is reduced to the level of a primary response, with concomitant reduction of CTL effector function. In contrast, Ab responses, as well as secondary CD4 T cell responses, to influenza are unaffected by 4-1BBL deficiency. Thus, CD28 is critical for initial T cell expansion, whereas 4-1BB/4-1BBL signaling affects T cell numbers much later in the response and is essential for the survival and/or responsiveness of the memory CD8 T cell pool. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/11937529/Temporal_segregation_of_4_1BB_versus_CD28_mediated_costimulation:_4_1BB_ligand_influences_T_cell_numbers_late_in_the_primary_response_and_regulates_the_size_of_the_T_cell_memory_response_following_influenza_infection_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=11937529 DB - PRIME DP - Unbound Medicine ER -